Liver fibrosis with persistently normal alanine transaminase levels exhibits a distinct treatment response in MASLD [0.03%]
持续转氨酶正常水平的肝纤维化在MASLD治疗中的特点反应不同
Ling Luo,Congxiang Shao,Long Teng et al.
Ling Luo et al.
Objective: Metabolic dysfunction-associated steatotic liver disease (MASLD) presents considerable variability in disease progression and treatment outcomes. We aimed to determine whether specific patterns of liver inflamm...
Effectiveness and safety of upadacitinib in a real-world cohort of patients with Crohn's disease in the UK: a multicentre retrospective cohort study [0.03%]
优瑞克利姆治疗英国真实世界队列中克罗恩病患者的有效性和安全性：一项多中心回顾性队列研究
Yaa Danso,Chandni Radia,Alex Elford et al.
Yaa Danso et al.
Objective: Upadacitinib is the first Janus kinase inhibitor and oral advanced therapy licensed for Crohn's disease (CD). Following NICE approval in 2023, real-world data on outcomes are limited. The effectiveness and safe...
Multicenter Study
BMJ open gastroenterology. 2025 Oct 6;12(1):e001916. DOI:10.1136/bmjgast-2025-001916 2025
Association between autoimmune disease and colorectal cancer: a retrospective case-control study of 120 876 patients [0.03%]
自身免疫性疾病与结直肠癌的相关性：一项120876例患者回顾性病例对照研究
Sven Heiko Loosen,Frederik Hansen,Tom Luedde et al.
Sven Heiko Loosen et al.
Objective: Colorectal cancer (CRC) is one of the most frequently diagnosed cancers and a leading cause of cancer-related deaths worldwide. While inflammatory bowel disease (IBD) is a well-established risk factor for CRC, ...
Machine learning in gastrointestinal endoscopy: challenges and opportunities [0.03%]
机器学习在胃肠内镜中的挑战与机遇
Sergejs Lobanovs,Jekaterina Aleksejeva,Alise Kitija Rūtiņa et al.
Sergejs Lobanovs et al.
The integration of machine learning (ML) into medical diagnostics has significantly advanced endoscopic examinations for gastrointestinal diseases. By leveraging extensive datasets and sophisticated algorithms, ML technologies enhance diagn...
Development and validation of the FR-QoL-29-Dutch (Flemish) Questionnaire and assessment of clinical factors associated with food-related quality of life in a Belgian inflammatory bowel disease population: a cross-sectional study [0.03%]
开发和验证荷兰语（佛兰德）FR-QoL-29问卷，并评估临床因素与比利时炎症性肠病人群饮食相关生活质量的关系：横断面研究
Judith Wellens,Livia Guadagnoli,Julie Vanderstappen et al.
Judith Wellens et al.
Objective: Food-related quality of life (FR-QoL) is the psychosocial impact of food, nutrition, eating and drinking on QoL and can be profoundly affected by inflammatory bowel disease (IBD). We aimed to translate and vali...
Lucía Guilabert,Sara Nikolìc,Enrique de-Madaria et al.
Lucía Guilabert et al.
The incidence of incidental pancreatic cystic lesions (PCLs) has risen in recent years, largely due to advances in and increased use of imaging techniques. Endoscopic ultrasound (EUS) has become a crucial tool for evaluating and characteris...
Large language models for extracting histopathologic diagnoses of colorectal cancer and dysplasia from electronic health records [0.03%]
基于电子健康记录的结直肠癌和上皮内瘤变的大规模语言模型病理诊断提取系统
Brian Johnson,Tyler Bath,Xinyi Huang et al.
Brian Johnson et al.
Objective: Accurate data resources are essential for impactful medical research, but available structured datasets are often incomplete or inaccurate. Recent advances in open-weight large language models (LLMs) enable mor...
Integrative genome-wide analysis unveils the genetic landscape of gallstone disease and highlights novel loci with therapeutic potential [0.03%]
整合基因组分析揭示了胆囊结石疾病的遗传图谱并提出了具有治疗潜力的新位点
Haotian Chen,Zhengye Liu,Hanze Du et al.
Haotian Chen et al.
Objective: Gallstone disease (GD) is a common gastrointestinal disorder with a significant genetic component. Despite known risk factors, the genetic basis of GD remains incompletely understood. We aimed to identify novel...
Priya Mistry,Hannah J Leach,Elizabeth R Buse et al.
Priya Mistry et al.
Intestinal failure (IF) is defined as 'the reduction of gut function below the minimum necessary for the absorption of macronutrients and/or water and electrolytes, such that intravenous supplementation is required to maintain health and/or...