Adebrelimab plus capecitabine versus capecitabine monotherapy for adjuvant treatment of high-risk resected cholangiocarcinoma (ACHIEVE): protocol for a phase II, multicentre, randomised controlled trial [0.03%]
阿德贝利单抗联合卡培他滨对比单药卡培他滨用于高危可切除胆管癌术后辅助治疗的多中心随机对照临床试验（ACHIEVE研究）：方案摘要
Yuan Cheng,Yaodong Zhang,Changxian Li et al.
Yuan Cheng et al.
Introduction: Cholangiocarcinoma (CCA) carries a high risk of recurrence even after curative resection. Capecitabine is standard adjuvant therapy, but recurrence rates remain significant, particularly in high-risk patient...
Triaging colorectal urgent referrals in the COVID-19 era using faecal immunochemical testing: a prospective UK real-world multicentre cohort study [0.03%]
新型冠状病毒肺炎时代应用免疫化学法检测粪便潜血筛查结直肠癌急诊转诊的分流策略：英国真实世界多中心队列研究
Gareth Walker,Supriya Balasubramanya,Joel Bowen et al.
Gareth Walker et al.
Objective: During the early COVID-19 pandemic, UK guidelines advocated faecal immunochemical tests (FIT) with a threshold of 10 µg/g to help secondary care clinicians triage urgent suspected colorectal cancer (CRC) refer...
Faecal occult blood testing: a review of its use and common misutilisation [0.03%]
粪便潜血试验：使用现状及常见误用概述
Gabriela Méndez,Lucía Rivera-Matos,Asim Shuja
Gabriela Méndez
Colorectal cancer (CRC) remains a leading cause of cancer-related morbidity and mortality worldwide, with early detection being crucial for improving patient outcomes. While colonoscopy is the gold standard for CRC screening, stool-based te...
Bone health, renal outcomes, and iron deficiency anaemia in proton pump inhibitor versus histamine-2 receptor antagonist users: a retrospective cohort study based on TriNetX global collaborative network data [0.03%]
一项基于TriNetX全球协作网络数据的回顾性队列研究：质子泵抑制剂与H2受体阻滞剂使用者的骨健康、肾脏结局和缺铁性贫血
To-Pang Chen,Ming-Ju Wu,Cheng-Hsu Chen et al.
To-Pang Chen et al.
Objective: Proton pump inhibitors' (PPIs) widespread use raises concerns about bone health, renal outcomes, and iron deficiency anaemia (IDA). We aim to address these concerns via comprehensive matching. ...
Comparative Study
BMJ open gastroenterology. 2025 Jul 13;12(1):e001723. DOI:10.1136/bmjgast-2024-001723 2025
Liver diseases, transaminases, and hepatobiliary-pancreatic cancer risk: a cohort and Mendelian randomisation study using data from UK Biobank [0.03%]
基于英国生物银行数据的前瞻性队列和孟德尔随机化研究：肝病、转氨酶与肝胆胰恶性肿瘤发病风险的关系研究
Yuan Yuan,Yong Jiang,Chonghui Hu et al.
Yuan Yuan et al.
Objective: Liver diseases are established risk factors for hepatobiliary and pancreatic cancers. This study explores the relationship between liver disease and hepatobiliary-pancreatic cancers, focusing on transaminase le...
Efficacy of a nasal mask oxygen kit versus regular nasal cannula in sedated gastrointestinal endoscopy: a multicentre, randomised clinical trial [0.03%]
鼻罩吸氧法与常规鼻导管吸氧法在镇静胃肠镜检查中的有效性对比：多中心随机临床试验
Xiangyang Cheng,Xiao Zhang,Jie Zhang et al.
Xiangyang Cheng et al.
Objective: The incidence of hypoxia in painless gastrointestinal endoscopy is not negligible. A nasal mask oxygen kit may reduce the incidence of hypoxia compared with a regular nasal cannula. ...
Randomized Controlled Trial
BMJ open gastroenterology. 2025 Jul 7;12(1):e001834. DOI:10.1136/bmjgast-2025-001834 2025
Enhancing ultrasonographic detection of hepatocellular carcinoma with artificial intelligence: current applications, challenges and future directions [0.03%]
人工智能增强超声检测肝细胞癌：当前应用、挑战及未来方向
Janthakan Wongsuwan,Teeravut Tubtawee,Sitang Nirattisaikul et al.
Janthakan Wongsuwan et al.
Background: Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality worldwide, with early detection playing a crucial role in improving survival rates. Artificial intelligence (AI), particularly...
Feasibility of a digital lifestyle intervention (VITALISE) to support weight loss in patients with MASLD in routine secondary care [0.03%]
用于常规二级护理中MASLD患者体重减轻的数字生活方式干预（VITALISE）的可行性研究
Leah Avery,Hollie Smith,Rebecca Livingston et al.
Leah Avery et al.
Objective: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common liver disease worldwide. Weight loss, achieved by changes to lifestyle behaviours, is the recommended management approach. How...
Association of distal adenoma and hyperplastic polyp characteristics with long-term proximal colon cancer risk: a secondary, observational analysis of data from the UK Flexible Sigmoidoscopy Screening Trial [0.03%]
基于英国结肠镜普查试验数据的二次观察分析：远端息肉与长期内侧结肠癌风险的关系
Rhea Harewood,Kate Wooldrage,Emma C Robbins et al.
Rhea Harewood et al.
Objectives: Colorectal cancer screening with flexible sigmoidoscopy focuses on the distal colorectum, but it is unclear which distal polyp characteristics are associated with future proximal colon cancer incidence. We exa...
Observational Study
BMJ open gastroenterology. 2025 Jun 23;12(1):e001787. DOI:10.1136/bmjgast-2025-001787 2025
Temporal trends in surgical treatment of inflammatory bowel disease following introduction of biological drugs in Norway and Sweden [0.03%]
挪威和瑞典引入生物制剂后炎症性肠病外科治疗的 temporal趋势
Amanda Högdén,Vera Perrin,Hans-Olov Adami et al.
Amanda Högdén et al.
Objective: The advent of biological drugs has revolutionised management of inflammatory bowel disease (IBD). However, the extent to which these novel pharmacological drugs have reduced the need for surgical treatment rema...