Effectiveness and safety of mirikizumab in ulcerative colitis: real-world data from the Latium Net [0.03%]
Mirikizumab治疗溃疡性结肠炎的有效性和安全性：拉齐奥网络的真实世界数据
Marco Murgiano,Paola Balestrieri,Emma Calabrese et al.
Marco Murgiano et al.
Objective: To evaluate the effectiveness and safety of mirikizumab in patients with ulcerative colitis in clinical practice. Methods: W...
Multicenter Study
BMJ open gastroenterology. 2026 May 5;13(1):e002232. DOI:10.1136/bmjgast-2025-002232 2026
Using the enhanced liver fibrosis test to identify disease in at-risk populations [0.03%]
采用增强型肝纤维化检测识别高危人群的疾病状况
Alex Hinkson,Jacob Feathers,Jason Punnamkuzhy et al.
Alex Hinkson et al.
Objective: Steatotic liver disease is common and has increased prevalence among those with type II diabetes mellitus or hazardous alcohol use. Identifying individuals with advanced liver disease early through screening ma...
Development and internal validation of the AGATE hybrid score for pre-endoscopic risk stratification in acute upper gastrointestinal bleeding: a single-centre, retrospective cohort study [0.03%]
AGATE混合评分的开发及内部验证：一项单中心回顾性队列研究 用于急性上消化道出血内镜前风险分层
Yavuz Özden,Ömer Yüzügülen,Ferhat Omurca
Yavuz Özden
Objective: To compare five established pre-endoscopic risk scores in acute upper gastrointestinal bleeding (AUGIB) and to derive a hybrid score (Acute Gastrointestinal Bleeding ABC-GBS Triage Evaluation (AGATE)) integrati...
Transarterial chemoembolisation-based combination therapy as a potential new standard for intermediate-stage hepatocellular carcinoma in the targeted immunotherapy era [0.03%]
经动脉化疗栓塞为基础的联合治疗有望成为靶向免疫治疗时代中期肝细胞癌的新标准治疗方法
Shuanggang Chen,Lujun Shen,Han Qi et al.
Shuanggang Chen et al.
Transarterial chemoembolisation (TACE) is the standard therapy for intermediate-stage hepatocellular carcinoma (HCC); however, its efficacy is limited by significant tumour heterogeneity. Recent landmark trials (EMERALD-1 and LEAP-012) demo...
Assessing the effect of single dose antibiotic prophylaxis compared with a multiday regimen in liver transplant recipients undergoing routine endoscopic retrograde cholangiopancreatography: a retrospective, single-centre, registry-based cohort study with a historical control group [0.03%]
单剂抗生素预防与多日方案在常规内镜逆行胰胆管造影的肝移植受者中的效果评估：一项基于登记表的队列研究，并设有历史对照组
Jessica Seeßle,Lara Ruhberg,Marietta Kirchner et al.
Jessica Seeßle et al.
Objective: Biliary complications, particularly anastomotic strictures, are common after liver transplantation (LT). The recommended duration of antibiotic prophylaxis after routine endoscopic retrograde cholangiopancreato...
Comparative Study
BMJ open gastroenterology. 2026 Apr 13;13(1):e002200. DOI:10.1136/bmjgast-2025-002200 2026
The 2026 IBD UK Standards of healthcare service design and delivery for adults and children living with Crohn's disease and ulcerative colitis [0.03%]
2026年英国炎症性肠病成人及儿童医疗服务标准
Christopher A Lamb,Catherine Picton,Ian Arnott et al.
Christopher A Lamb et al.
Objective: Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, requires consistent high-quality care to reduce variation in patient experience and improve outcomes. The IBD Standards previo...
Dyssynergia phenotypes in obstructed defecation: insights from Fecobionics assessment [0.03%]
排便障碍型dyssynergia的表型：来自Fecobionics评估的见解
Wenbo Li,Mingyang Hou,Yi Li et al.
Wenbo Li et al.
Objective: Obstructed defecation syndrome (ODS) is a chronic constipation subtype. Conventional tests are limited by non-physiological conditions and poor correlation with symptoms. This study investigated anorectal dynam...
Observational Study
BMJ open gastroenterology. 2026 Apr 7;13(1):e002212. DOI:10.1136/bmjgast-2025-002212 2026
Antiviral treatment and statin use and risk of decompensated cirrhosis in patients with hepatitis C: a time-dependent analysis of a retrospective cohort study [0.03%]
抗病毒治疗和他汀类药物使用与丙型肝炎患者失代偿性肝硬化的风险：回顾性队列研究的时变分析
Kimberly A Brown,Stuart C Gordon,Yichu Wang et al.
Kimberly A Brown et al.
Objective: Sustained virological response (SVR) in patients with hepatitis C virus (HCV) is associated with slower progression of cirrhosis. Likewise, statin treatment is associated with delayed cirrhosis progression, but...
Advancing global equity in liver disease research funding: the case of metabolic dysfunction-associated and alcohol-associated liver disease [0.03%]
推进非酒精性和酒精性肝病研究资金的全球公平性：以代谢紊乱相关性肝病和酒精相关性肝病为例
Daniel J Huynh,Matthew Obusan,Jinny Lu et al.
Daniel J Huynh et al.
Multiomic characterisation of the clinical efficacy of guselkumab induction therapy in ulcerative colitis [0.03%]
Guselkumab诱导治疗溃疡性结肠炎的临床疗效多组学特征分析
Amy Hart,Sunandini Sridhar,Swati Venkat et al.
Amy Hart et al.
Objective: Selective inhibition of interleukin (IL)-23 through antagonism of the IL-23p19 subunit has demonstrated clinical efficacy in inflammatory bowel disease, but the molecular changes underlying the efficacy outcome...