Dyssynergia phenotypes in obstructed defecation: insights from Fecobionics assessment [0.03%]
排便障碍型dyssynergia的表型：来自Fecobionics评估的见解
Wenbo Li,Mingyang Hou,Yi Li et al.
Wenbo Li et al.
Objective: Obstructed defecation syndrome (ODS) is a chronic constipation subtype. Conventional tests are limited by non-physiological conditions and poor correlation with symptoms. This study investigated anorectal dynam...
Observational Study
BMJ open gastroenterology. 2026 Apr 7;13(1):e002212. DOI:10.1136/bmjgast-2025-002212 2026
Antiviral treatment and statin use and risk of decompensated cirrhosis in patients with hepatitis C: a time-dependent analysis of a retrospective cohort study [0.03%]
抗病毒治疗和他汀类药物使用与丙型肝炎患者失代偿性肝硬化的风险：回顾性队列研究的时变分析
Kimberly A Brown,Stuart C Gordon,Yichu Wang et al.
Kimberly A Brown et al.
Objective: Sustained virological response (SVR) in patients with hepatitis C virus (HCV) is associated with slower progression of cirrhosis. Likewise, statin treatment is associated with delayed cirrhosis progression, but...
Advancing global equity in liver disease research funding: the case of metabolic dysfunction-associated and alcohol-associated liver disease [0.03%]
推进非酒精性和酒精性肝病研究资金的全球公平性：以代谢紊乱相关性肝病和酒精相关性肝病为例
Daniel J Huynh,Matthew Obusan,Jinny Lu et al.
Daniel J Huynh et al.
Multiomic characterisation of the clinical efficacy of guselkumab induction therapy in ulcerative colitis [0.03%]
Guselkumab诱导治疗溃疡性结肠炎的临床疗效多组学特征分析
Amy Hart,Sunandini Sridhar,Swati Venkat et al.
Amy Hart et al.
Objective: Selective inhibition of interleukin (IL)-23 through antagonism of the IL-23p19 subunit has demonstrated clinical efficacy in inflammatory bowel disease, but the molecular changes underlying the efficacy outcome...
Cardiovascular health assessed by Life's Essential 8 score, genetic risk, colonoscopy status, and risk of colorectal cancer: an analysis of UK Biobank [0.03%]
基于UK生物样本库对心血管健康（利用生活八大基本要素评估分数、遗传风险和结肠镜检查状态）与结直肠癌风险关系的分析
Chengmiao Qiu,Mengyang Wang,Shujuan Lin et al.
Chengmiao Qiu et al.
Objective: Colorectal cancer (CRC) and cardiovascular disease (CVD) share common risk factors. This study explores the association between cardiovascular health (CVH), assessed using the Life's Essential 8 (LE8) score, an...
Advanced imaging (narrow band and acetic acid chromoendoscopy) and guided biopsies in surveillance of Barrett's oesophagus: a systematic review [0.03%]
巴雷特食管内镜监测中窄带和醋酸染色内镜的应用及引导活检：一项系统性回顾
Champika Gamakaranage,Thomas David Butler,Elizabeth Ratcliffe et al.
Champika Gamakaranage et al.
Objectives: To systematically synthesise the evidence behind the use of narrow band imaging (NBI) and acetic acid chromoendoscopy (AAC) in Barrett's oesophagus (BO) surveillance. ...
Development of an optimal pathway for endoscopic sleeve gastroplasty implementation in the NHS: a modified nominal group technique study [0.03%]
英国国家医疗服务体系内内镜袖状胃成型术实施的优化路径开发：一种改良名义群体技术研究
Andrew Currie,Francis O&#x;Neill,Bu Hayee et al.
Andrew Currie et al.
Objective: The UK faces a significant obesity crisis, and multiple management options are now available, including pharmacotherapy, endoscopic and surgical interventions. Endoscopic Sleeve Gastroplasty (ESG) has emerged a...
Using an integrative multi-omics and in vitro approach to investigate the role of tris(2-butoxyethyl) phosphate in promoting hepatic steatosis [0.03%]
利用整合多组学和体外方法探究新污染物TBOEP促进肝脂肪变性的机制研究
Gang Zhou,Xihan Gu,Xinyao Zhou et al.
Gang Zhou et al.
Objective: To investigate the potential role of the environmental pollutant tris(2-butoxyethyl) phosphate (TBOEP) in the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD) and to elucidate it...
Association of extraintestinal manifestations and disease severity in paediatric inflammatory bowel disease: a multicentre cohort study [0.03%]
儿童炎症性肠病的肠外表现与疾病严重程度之间的关联：一项基于多中心队列的研究
Ágnes Eszter Tímár,Márk Hernádfői,Brigitta Teutsch et al.
Ágnes Eszter Tímár et al.
Objective: Extraintestinal manifestations (EIMs) are common in paediatric inflammatory bowel disease (IBD), often impairing quality of life. Our aim was to assess whether EIMs at diagnosis are associated with disease seve...
Multicenter Study
BMJ open gastroenterology. 2026 Feb 24;13(1):e002130. DOI:10.1136/bmjgast-2025-002130 2026
Evaluating treatment to a target of transmural healing in patients with moderately to severely active Crohn's disease: rationale, design and protocol for the randomised controlled VECTORS trial [0.03%]
评价针对中至重度活动性克罗恩病患者壁内愈合目标的治疗：随机对照VECTORS试验的理由、设计和方案
Vipul Jairath,Sudheer K Vuyyuru,Guangyong Zou et al.
Vipul Jairath et al.
Introduction: The optimal treatment target for Crohn's disease (CD) is unknown. Targeting transmural healing (TMH) may be associated with a lower risk of complications than clinical and endoscopic outcomes. The Study to E...