Bexotegrast for treatment of idiopathic pulmonary fibrosis (BEACON-IPF): study protocol for a multinational, phase 2b/3, double-blind, randomised, multicentre, controlled trial [0.03%]
贝西奥泰格司治疗特发性肺纤维化（BEACON-IPF）：多国、IIb/III期、双盲、随机、多中心对照试验方案
Wim A Wuyts,Lisa Lancaster,Toby M Maher et al.
Wim A Wuyts et al.
Introduction: Bexotegrast is an oral, once-daily, dual-selective inhibitor of integrins αvβ6 and αvβ1 in development for idiopathic pulmonary fibrosis (IPF). In the phase 2a study INTEGRIS-IPF study (NCT04396756), bex...
ClusterVAP: study protocol for multicentre proteomic endotyping of ventilator-associated pneumonia [0.03%]
ClusterVAP：通气相关性肺炎多中心蛋白组学内型研究方案
Fredrik Sjövall,Pedro Póvoa,Johan Petersson et al.
Fredrik Sjövall et al.
Introduction: Ventilator-associated pneumonia (VAP) is the most frequent healthcare-associated infection in intensive care units and is associated with high morbidity and mortality. Current diagnostic criteria lack specif...
Managing pleural infections: a nationwide survey of respiratory physicians in Singapore [0.03%]
管理胸膜感染：新加坡全国呼吸科医师调查
Ken Junyang Goh,Glenn Khai Wern Yong,Dipika Agrawal et al.
Ken Junyang Goh et al.
Background: Pleural infection remains a major cause of morbidity and mortality, with a significant healthcare burden. Despite growing research and guideline recommendations, real-world management continues to vary widely....
Understanding real-world effectiveness of nirsevimab and the characteristics of breakthrough RSV infections: a study protocol of individual-participant-level data meta-analysis (the GEMINI study) [0.03%]
nirsevimab真实世界有效性的特点及突破性RSV感染的特征：个体参与者数据荟萃分析(GEMINI研究)方案
Shaolong Ren,Han Zhang,Shuyu Deng et al.
Shaolong Ren et al.
Introduction: The recent rollout of nirsevimab across multiple countries represents an important advancement in respiratory syncytial virus (RSV) prevention. However, real-world evidence on how its effectiveness varies wi...
Efficacy and safety of as-needed albuterol-budesonide versus albuterol in patients with asthma aged 12 to [0.03%]
按需使用沙美特罗-氟替卡松与仅使用沙美特罗治疗12至80岁哮喘患者的疗效和安全性：一项随机、双盲、平行组3期非劣效性研究
Leonard Benjamin Bacharier,Hengameh Raissy,Samuel Bardsley et al.
Leonard Benjamin Bacharier et al.
Introduction: Asthma among adolescents (aged 12-
Phase 2a randomised, double-blind, placebo-controlled study to evaluate the efficacy and safety of londamocitinib (AZD4604) two times per day for 12 weeks in adult patients with moderate-to-severe asthma uncontrolled on medium-high-dose ICS-LABA [0.03%]
一项多中心、随机、双盲、安慰剂对照IIa期研究，评估两次每日londotrelor（AZD4604）12周治疗中至重度吸入性皮质类固醇联合长效β受体激动剂控制不佳的成年哮喘患者的疗效和安全性
Mohd Nubli Mustapa,Rod Hughes,Tina J Jensen et al.
Mohd Nubli Mustapa et al.
Introduction: Asthma is a heterogeneous condition and affected individuals show variable responses to available medications. An unmet need exists for add-on therapies that target novel molecular pathways, before patients ...
Associations between breathlessness and individuals' satisfaction with sexual life: a nationally representative internet survey [0.03%]
呼吸困难与个人性生活的满意度之间的关系——一项全国性的网络调查研究
Max Olsson,Jacob Sandberg,Slavica Kochovska et al.
Max Olsson et al.
Introduction: Sexual life is important for many people and may be limited by breathlessness. We evaluated associations between breathlessness and individuals' perceived satisfaction with sexual lives and explored mediatin...
Societal and personal financial burden of severe asthma and impact of biologic therapy: a 19-year nationwide cost analysis [0.03%]
重度哮喘的社会和个人经济负担及生物制剂治疗的影响：一项全国范围内19年的成本分析
Kjell E J Håkansson,Rikke Ibsen,Niels Steen Krogh et al.
Kjell E J Håkansson et al.
Introduction: Severe asthma incurs a financial burden on both patients and societies. However, little is known about the long-term financial burden and impact of biologic therapy. ...
Pulmonary function and airflow limitation in bronchiectasis: a case-control study of two independent cohorts [0.03%]
支气管扩张症患者的肺功能和气流受限：一项基于两组独立队列的病例对照研究
Da Som Jeon,Young Ju Jung,Soo Han Kim et al.
Da Som Jeon et al.
Background: Bronchiectasis is a respiratory disease structurally characterised by irreversible airway dilatation. Functional impairments are also implicated in bronchiectasis, but the detailed changes in pulmonary functio...
Multicenter Study
BMJ open respiratory research. 2026 Mar 5;13(1):e002530. DOI:10.1136/bmjresp-2024-002530 2026
PRHOCARER study: protocol for a multicentre, convergent, mixed-methods trial assessing the effectiveness of pulmonary rehabilitation programmes and the needs of informal carers of people with chronic respiratory diseases [0.03%]
一项关于肺康复项目有效性的多中心、聚合型混合方法试验的方案：评估慢性呼吸系统疾病患者的非正式护工的需求（PRHOCARER研究）
Manon Robic,Jean-Marie Grosbois,Michael Racodon et al.
Manon Robic et al.
Introduction: As the population ages, informal carers play an increasingly essential role in supporting patients with chronic respiratory diseases (CRDs), often at the expense of their own health. While the psychological ...