Mauro Gemmi,Lukáš Palatinus,Philippe Boullay et al.
Mauro Gemmi et al.
3D electron diffraction (3D ED) has undergone impressive development in the last decade. However, its accuracy and reproducibility have never been tested, up to now, in different laboratories on the same batch of samples. This paper reports...
Modelling of radiation damage and beam-induced heating of room-temperature samples at extremely high flux MX beamlines [0.03%]
极高科技含量的MX光束线室温样品的辐射损伤及光束引起的加热模拟研究
Martin V Appleby,Michal W Kepa,Graeme Winter et al.
Martin V Appleby et al.
The upgrade of the third-generation synchrotrons to diffraction-limited storage rings will enable a gain of up to two orders of magnitude in brilliance and further enable the creation of multiple macromolecular crystallography (MX) beamline...
Application of differential scanning fluorimetry to X-ray protein crystallography [0.03%]
差示扫描荧光在X-射线蛋白结晶学中的应用
Yukari Sato,Toshiya Senda
Yukari Sato
X-ray crystallography remains a powerful technique for determining high-resolution protein structures; however, obtaining high-quality crystals is a significant bottleneck. This study presents a detailed experimental workflow that employs d...
Automated microbatch-under-oil phase diagrams to rationalize serial crystallography sample preparation [0.03%]
自动化微批量油下相图理性化连续晶体学样品制备
Jack Stubbs,Courtney J Tremlett,Abigail Waitman et al.
Jack Stubbs et al.
Serial crystallography relies on the reproducible production of high-density suspensions of microcrystals, yet sample optimization remains a resource-intensive bottleneck. While phase diagrams provide a theoretical framework for controlling...
Catching new modulated high-pressure phases of δ-chlorpropamide: when the experimental setup matters [0.03%]
新的调制高压δ-氯苯甲酰胺相的捕捉：实验装置的影响
Nikita E Bogdanov,Sergey V Rashchenko,Boris A Zakharov et al.
Nikita E Bogdanov et al.
The antidiabetic drug chlorpropamide [1-(4-chlorophenyl)sulfonyl-3-propylurea, CPA] has one of the highest numbers of reported polymorphs, making it an excellent model system for studying structural responses to pressure or temperature. The...
Stereochemical aspects of the nucleophilic attack in different classes of L-asparaginases [0.03%]
不同类别的L-天冬酰胺酶中亲核进攻的立体化学方面
Miroslaw Gilski,Kinga Pokrywka,Mariusz Jaskolski
Miroslaw Gilski
L-Asparaginases hydrolyze L-asparagine to L-aspartate with the release of ammonia. Currently, three completely unrelated structural classes of L-asparaginases are known, further subdivided into five types. In each class, the hydrolysis reac...
Dominik Oberthür
Dominik Oberthür
Advances in serial crystallography have reshaped approaches to radiation damage at room temperature. This commentary highlights recent work comparing XFEL and synchrotron experiments, emphasizing its implications for serial crystallography ...
Cinzia Giannini
Cinzia Giannini
The novel analytical approach for interpreting complex X-ray diffraction patterns from fibers described by Wang et al. [(2026), IUCrJ, 13, https://doi.org/10.1107/S2052252525009686] is discussed. ...
Shitao Wu,Yanhang Ma
Shitao Wu
A user-friendly interface has been developed for XDS, enabling efficient real-time and batch processing of 3D ED data to accelerate structure determination. ...
Phase transitions in rutile-related V0.92O2 synthesized at high pressures and temperatures [0.03%]
高压低温合成的与金红石相关的V0.92O2中的相变现象
Andrzej Grzechnik,Václav Petříček,Pascal Reiss et al.
Andrzej Grzechnik et al.
Structural phase transitions in metastable rutile-related V0.92O2 synthesized at 10 GPa and 1273 K were studied with single-crystal X-ray diffraction in the temperature range 110-500 K and at pressures up to 9.2 GPa. V0.92O2 starts to decom...