The Therapeutic Potential of Andrographolide and Its Derivatives in Inflammatory Diseases [0.03%]
andrographolide及其衍生物在炎症性疾病治疗中的潜力
Xiaoqin Shan,Siyi Li,Jiayi Liu et al.
Xiaoqin Shan et al.
Andrographolide, a diterpenoid component found in traditional Chinese medicine Andrographis paniculata, is known as a natural antibiotic and can be used to treat inflammatory lesions of various systemic diseases. In recent years, andrograph...
Team-Based Learning in the Meta Horizon Workroom: A Pilot Study on Its Potential Effectiveness for Pharmacology Teaching [0.03%]
基于团队的学习在Meta地平线工作坊中的试点研究及其对药理学教学的潜在有效性
Abdullah Khaiyam,Lucy Battersby,Ellie Porter et al.
Abdullah Khaiyam et al.
The Meta Horizon Workroom (MHW) provides an immersive environment for team-based learning (TBL). This study evaluated its effectiveness in teaching pharmacology, emphasizing engagement, collaboration, and learning, aiming to assess the pote...
Ceftazidime-Avibactam Pharmacokinetic Comparative In Vivo/In Vitro Study in a Critically Ill Children Under High-Volume Continuous Venovenous Hemodiafiltration [0.03%]
头孢他啶-阿维巴坦在重症儿童患者体内的药代动力学比较体内/体外研究（该患者正在接受大容量连续静脉-静脉血浆滤过治疗）
Michael Thy,Alexandre Debs,Gabrielle Lui et al.
Michael Thy et al.
Ceftazidime-avibactam is a novel cephalosporin/beta-lactamase inhibitor combination developed to address increasing antimicrobial resistance. This report presents a comparative study of the pharmacokinetics of ceftazidime and avibactam, uti...
Repurposing the Antidepressant Sertraline: A Systematic Scoping Review of Its Anticancer Mechanisms [0.03%]
抗抑郁药物舍曲林的再利用：其抗癌机制的系统综述性审查
Ciara B Blum,McCarlie-Jayne Dohrmann,Lucia McCarthy et al.
Ciara B Blum et al.
Drug repurposing offers a cost-effective and time-efficient strategy for identifying new cancer therapies. Sertraline, a widely prescribed selective serotonin reuptake inhibitor (SSRI), has shown promising anticancer properties through modu...
Hexahydrocannabinol and Hexahydrocannabiphorol Poisonings: Data From the Czech Toxicology Information Centre and Effects of Legislative Changes [0.03%]
六氢大麻酚和六氢大麻二酚中毒：来自捷克毒物信息中心的数据及立法变更的影响
Michal Čečrle,Milada Běhounková,Kateřina Kotíková et al.
Michal Čečrle et al.
Hexahydrocannabinol, a hydrogenated derivative of cannabinol, first came to the Czech Toxicological Information Centre (TIC) following reports of poisonings in May 2022. We conducted a retrospective observational study examining self-report...
Observational Study
Pharmacology research & perspectives. 2025 Oct;13(5):e70162. DOI:10.1002/prp2.70162 2025
Closing the Evidence Gap: Retrospective and Prospective Strategies to Advance Aripiprazole's Potential Benefits in Patients With Cancer [0.03%]
填补证据缺口：回顾性和前瞻性策略促进阿立哌唑在癌症患者中潜在益处的发展
Elvira Meni Maria Gkrinia,Marin Golčić,Andrej Belančić
Elvira Meni Maria Gkrinia
6-Nitrodopamine Release From Mouse Seminal Vesicles Is Dependent on Endothelial Nitric Oxide Synthase (eNOS) Activation [0.03%]
硝基多巴胺从小鼠精囊的释放依赖内皮型一氧化氮合酶(eNOS)的激活
José Britto-Júnior,Pérola Rafaella Cedano Godoy,Denis Oliveira Lima et al.
José Britto-Júnior et al.
Human seminal vesicles present basal release of epithelium-derived 6-nitrodopamine (6-ND) and this catecholamine potentiates noradrenaline-induced contractions. Since nitric oxide synthase (NOS) activation is a determining factor involved i...
A Randomized, Open-Label, Single-Dose, Parallel-Group Bioequivalence Study of Ferric Carboxymaltose Injection Under Fasting Conditions in Chinese Adult Subjects With Iron Deficiency Anemia [0.03%]
铁缺乏性贫血成人受试者空腹条件下右旋糖酐铁注射液单次给药的随机、开放、平行对照生物等效性试验
Fengyun Gong,Shengling Hu,Jiandong Yuan et al.
Fengyun Gong et al.
The objectives of this study were to compare the pharmacokinetics and safety profiles of the test (T) preparation (Ferric carboxymaltose injection, BrightGene Bio-Medical Technology Co. Ltd.) and reference (R) preparation (Ferinject, Vifor ...
Randomized Controlled Trial
Pharmacology research & perspectives. 2025 Oct;13(5):e70137. DOI:10.1002/prp2.70137 2025
Saliva Based Clozapine Therapeutic Drug Monitoring: A Systematic Review [0.03%]
基于唾液的氯氮平治疗药物监测：系统评价研究
Tessa Rademaker,Rachel Chu,Suhaila Hasan et al.
Tessa Rademaker et al.
Clozapine is superior in the treatment of treatment-refractory schizophrenia but requires therapeutic drug monitoring (TDM) due to its unpredictable pharmacokinetics and dose-dependent side effects. This systematic review evaluates saliva a...
Preclinical Evaluation of the Oral Toxicity, Genotoxicity, and Safety Pharmacology of LPM4870108, a Novel Potent Tropomyosin Receptor Kinase Inhibitor [0.03%]
LPM4870108（一种新型强力肌动蛋白受体激酶抑制剂）的口腔毒性、遗传毒理学和安全药理学的临床前评估
Xiaochen Zhang,Baiyang Yuan,Chunmei Li et al.
Xiaochen Zhang et al.
Tropomyosin receptor kinase (Trk) inhibitors are an essential class of anticancer drugs treating NTRK gene fusions-positive cancer. However, the potential for the emergence of on-target resistance suggests newer Trk inhibitors with low drug...