Glycine Reverses Behavioral Deficits in a Mouse Model for Psychosis With 4 Copies of the Gldc Gene [0.03%]
甘氨酸通过增加Gldc基因剂量逆转精神行为异常
Muxiao Wang,Maltesh Kambali,Jinrui Lyu et al.
Muxiao Wang et al.
A duplication/triplication copy number variant in the 9p24.1 chromosomal region with the additional gene copies being located on a small supernumerary marker chromosome has been identified in patients with psychosis. Mice genetically engine...
E J Kuijer,L H Marinelli,S J Bailey et al.
E J Kuijer et al.
Nalfurafine is the only clinically approved kappa opioid receptor (KOPr) agonist that can cross the blood-brain barrier and exert CNS effects. Because its clinical use is not associated with dysphoria, it is widely believed to have an atypi...
Peripheral Neuropathy Associated With Proteasome Inhibitors and Immunomodulatory Drugs: A Pharmacovigilance Disproportionality Analysis Using VigiBase [0.03%]
蛋白酶体抑制剂和免疫调节药物相关周围神经病变：源于VigiBase的药物警戒信号分析
Letícia Penna Braga,Cristiane Aparecida Menezes de Pádua,Iwyson Henrique F da Costa et al.
Letícia Penna Braga et al.
Immunomodulatory drugs (IMIDs) and proteasome inhibitors (PIs) are part of the frontline treatment landscape for multiple myeloma (MM). Despite their effectiveness, these drugs are associated with adverse effects, particularly clinically si...
Effect of Thrombopoietin Receptor Agonist Romiplostim on the Ionizing Radiation-Induced Premature Aging [0.03%]
血小板生成素受体激动剂罗米司亭对离子辐射所致早衰的影响
Masaru Yamaguchi,Tokuhisa Hirouchi,Yoshiaki Sato et al.
Masaru Yamaguchi et al.
Environmental stressors, such as ionizing radiation, accelerate aging by causing DNA damage and triggering pathways that lead to cell cycle arrest, apoptosis, and subsequent inflammation. The thrombopoietin receptor agonist romiplostim (RP)...
Closing the Numeracy Gap in Medication Safety: Impact of a safeMedicate Intervention in Undergraduate Medical Education [0.03%]
安全用药干预对医学教育的作用：safeMedicate干预在医学教育中的影响
Soban Sadiq,Susan Driver,Manfred Gschwandtner
Soban Sadiq
Medication errors, often linked to inadequate numeracy skills, pose significant risks to patient safety. To address this, Kent and Medway Medical School (KMMS) became the first UK medical school to integrate safeMedicate, a validated e-lear...
A Single Dose, Randomized, Open-Label, Cross-Over Bioequivalence Study of Budesonide Pressurized Metered-Dose Inhaler in Healthy Chinese Subjects [0.03%]
布地奈德压氏吸气雾剂在中国受试者中的单次给药、随机开放标签、双期交叉生物等效性研究
Kai Huang,Shaohong Yin,Weiguo Huang et al.
Kai Huang et al.
Budesonide is a first-line inhaled glucocorticoid (ICS) for asthma treatment in adults and children. The purpose of this study was to compare the pharmacokinetics and assess the bioequivalence between two budesonide pressurized metered-dose...
Randomized Controlled Trial
Pharmacology research & perspectives. 2025 Dec;13(6):e70197. DOI:10.1002/prp2.70197 2025
Correction to "The MAO-B Inhibitor Selegiline Reduces the Viability of Different Prostate Cancer Cell Lines and Enhances the Effects of Anti-Androgen and Cytostatic Agents" [0.03%]
“MAO-B抑制剂司来吉兰降低不同前列腺癌细胞系的存活率并增强抗雄激素和细胞毒性药物的作用”的纠正意见
Published Erratum
Pharmacology research & perspectives. 2025 Dec;13(6):e70198. DOI:10.1002/prp2.70198 2025
Unbiased microRNA-Disease Association Prediction Using ICD-11 Codes and Negative Sampling [0.03%]
基于ICD-11代码和负样本采样的无偏miRNA疾病关联预测方法
Munyoung Chang,Jeonghee Jo,Junyong Ahn et al.
Munyoung Chang et al.
We developed a computational model, called "Unbiased microRNA-disease association predictor (UBMDA)," to predict microRNA-disease associations. UBMDA has two major differences from those reported previously. First, we did not apply a simila...
Impact of Dihydrocapsaicin on the Metabolism of Efavirenz In Vitro and In Vivo [0.03%]
二氢辣椒素对埃夫替拉韦代谢的体内外影响研究
Bo Wang,Xu Ma,Xinggao Wang et al.
Bo Wang et al.
Efavirenz (EFV) is the first-line treatment for acquired immunodeficiency syndrome. However, capsaicin may affect its properties, although the underlying mechanisms remain unknown. This study aimed to investigate the effects of dihydrocapsa...
Effects of Botrychium ternatum (Thunb) Sw. On Cytochrome P450 Activities in Rats [0.03%]
Botrychium ternatum (Thunb) SW.对大鼠细胞色素P450活性的影响
Jiange Yao,Liming Hu,Quan Zhou et al.
Jiange Yao et al.
Drug interactions commonly occur through the activities of cytochrome P450 (CYP). In this study, we evaluated the effects of the Chinese herbal medicine Botrychium Ternatum (Thunb) Sw. (BT) on six CYP enzymes. Twelve healthy male Sprague-Da...