Kaempferol Improves Alzheimer's Disease by Inhibiting Neuronal Ferroptosis via Activating GPX4/AKR1C3 Signaling Pathway [0.03%]
Le Li,Manying Yang,Jiale Tao et al.
Le Li et al.
Kaempferol has been shown to be beneficial in the treatment of Alzheimer's disease (AD) in animal models. However, the action mechanism remains unclear. AKR1B1 has been identified as a target of kaempferol, initially suggested by the Therap...
Implementation of an Integrated Pharmacology Curriculum in a Flipped, Small-Group, Case-Based, Pre-Clerkship Medical Curriculum Improved Student Performance [0.03%]
Brinda Desai Bradaric,Eric Van Rite,Lalita Prasad-Reddy et al.
Brinda Desai Bradaric et al.
Rush Medical College implemented a new, integrated pre-clerkship curriculum. Pharmacology was integrated with other basic sciences into a flipped, small-group, case-based structure. This report describes the main features of the pharmacolog...
Magnitude, Preventability, and Determinants of Adverse Drug Reactions Among Hospitalized Obstetric Patients in Ethiopia: A Prospective Observational Study [0.03%]
一项关于埃塞俄比亚住院产妇药物不良反应的发生率、可预防性和决定因素的前瞻性观察研究：伦理审查批文号：LMRPG-2019.0588-PCHS
Getachew Yitayew Tarekegn,Endalemaw Tsegaw,Fisseha Nigussie Dagnew et al.
Getachew Yitayew Tarekegn et al.
Adverse drug reactions (ADRs) are an important and potentially preventable cause of morbidity among hospitalized obstetric patients, with implications for both maternal and fetal safety, yet evidence from low-resource settings remains limit...
Observational Study
Pharmacology research & perspectives. 2026 Jun;14(3):e70248. DOI:10.1002/prp2.70248 2026
Combined Inhibition of TRPM4/NMDA Receptor Complex and Extrasynaptic NMDA Receptors Is Candidate Therapeutic Target for Suppression of Epileptic Seizures and Improvement of Cognitive Impairments [0.03%]
联合抑制TRPM4/NMDA受体复合物和胞外NMDA受体是抑制癫痫发作和改善认知障碍的候选治疗靶点
Motohiro Okada,Ruri Okubo,Tomoka Oka et al.
Motohiro Okada et al.
Cognitive impairments are important therapeutic targets in epilepsy medication; however, effective pharmacological treatments for epilepsy patients with comorbid cognitive impairment have not been established. Effects of chronic administrat...
Pharmacologic MRI Brain Imaging Studies of Serotonin 5-HT1 Receptor Agonists in Awake Mice [0.03%]
觉醒小鼠五羟色胺5-HT1受体激动剂的药理磁共振脑成像研究
Brittany M Brems,Erin E Sullivan,Ryan P McGlynn et al.
Brittany M Brems et al.
Serotonin (5-hydroxytryptamine, 5-HT) type-1 G protein-coupled receptors are expressed throughout the central nervous system. 5-HT1AR activation is the putative mechanism of approved drugs for generalized anxiety disorder and major depressi...
Metformin as a Multifaceted Therapeutic Agent for Gastrointestinal Diseases: Mechanisms, Clinical Efficacy, and Future Directions [0.03%]
二甲双胍在胃肠疾病治疗中的多效性：机制、临床疗效和未来方向
Sayedeh Azimeh Hosseini,Hassan Valadbeigi,Seyedeh Mahdieh Khoshnazar et al.
Sayedeh Azimeh Hosseini et al.
The high prevalence of gastrointestinal (GI) diseases and their significant impact on the quality of life require new therapeutic strategies. The development of novel therapeutic strategies should prioritize targeting the fundamental pathop...
Age-Dependent Differences in Canakinumab Safety: A Comprehensive Pharmacovigilance Analysis Using the FAERS Database [0.03%]
基于FAERS数据库的卡那奴单抗安全性的年龄依赖性差异的全面药物警戒分析
Youyang Wang,Ngasin Lam,Xiaoming Huang et al.
Youyang Wang et al.
While the efficacy of canakinumab, an anti-interleukin-1β monoclonal antibody, is well-established, its safety profile, particularly across different age groups, remains inadequately explored. Using the FDA Adverse Event Reporting System (...
Behavioral Domain-Specific Effects of Positive Modulation of α5 and α6 GABAA Receptors in a Rat Double-Hit Stress Model [0.03%]
α5和α6型GABAA受体正向调节在大鼠双重打击应激模型中的行为域特异性效应
Đorđe Đorović,Jovana Aranđelović,Jana Ivanović et al.
Đorđe Đorović et al.
Impulsivity is an understudied area of post-traumatic stress disorder, a debilitating disorder specifically associated with stress. We examined reward-related impulsive behavior, anxiety-like behavior, locomotor activity and social behavior...
Intravenous Tolvaptan Sodium Phosphate Can Fail to Improve Fluid Overload Due to Heart Failure in Patients With Chronic Kidney Disease: A Case Report [0.03%]
托伐普坦钠磷酸盐静脉注射对慢性肾脏病合并心力衰竭患者液体过负荷改善无效的病例报告
Takaya Uno,Ichiro Nakakura,Akari Ikeda et al.
Takaya Uno et al.
Tolvaptan is widely used as an adjunct oral diuretic to loop and thiazide diuretics for the management of fluid overload in patients with congestive heart failure. Recently, tolvaptan sodium phosphate (TSP), a water-soluble prodrug of tolva...
Damnacanthal Suppresses Breast Cancer Cells by Inducing Apoptosis and Cell Cycle Arrest via NF-ĸB Signaling [0.03%]
Damnacanthal通过NF-κB信号诱导乳腺癌细胞凋亡和周期阻滞抑制乳腺癌细胞
Onnichar Jongcharoen,Somrudee Reabroi,Pimtip Sanvarinda et al.
Onnichar Jongcharoen et al.
Breast cancer is the most common cancer diagnosed and the leading cause of death for women worldwide. Noni (Morinda citrifolia L.) contains an anthraquinone called damnacanthal (3-hydroxy-1-methoxy-anthraquinone-2-aldehyde), which is known ...