Promoting Sustainable Prescribing-A Case Study Presenting Experiences From Two Swedish Drug and Therapeutics Committees [0.03%]
促进可持续用药供给——来自两个瑞典药物与治疗委员会的经验案例分析
Björn Ericsson,Ulf Lindahl,Johanna Villén et al.
Björn Ericsson et al.
During the past two decades, it has become evident that pharmaceuticals is an emerging environmental problem. In this study, we present the experiences from two Swedish Drug & Therapeutics Committees (DTCs) on how they integrate environment...
Student and Graduate Perceptions of Their Development of the Core Attitudes From the British Pharmacological Society's Undergraduate Pharmacology Curriculum [0.03%]
英国药理学会本科药理学课程核心态度培养的学员及毕业生认知研究
Sophie G Reed,Aidan Seeley,Nicola Williams et al.
Sophie G Reed et al.
The British Pharmacological Society's undergraduate core curriculum defines 18 core attitudes that pharmacology students should have after the completion of their degree. While the attainment of pharmacological knowledge and application of ...
Leveraging Administrative Health Data to Capture Rare Adverse Drug Reactions: Identifying Pediatric Patients With Trimethoprim-Sulfamethoxazole Acute Respiratory Distress Syndrome [0.03%]
利用管理健康数据捕捉罕见的药物不良反应：识别使用曲马多-磺胺甲恶唑急性呼吸窘迫综合征的儿科患者
Keith Feldman,Jenna O Miller,Katherine Doane et al.
Keith Feldman et al.
Rare adverse drug reactions (ADRs) are underrecognized and underreported in the electronic medical record (EMR). These events often require clinical review, making systematic identification challenging. The study aim was to develop an appro...
Differential Impact of Pharmacokinetic and Pharmacodynamic Variability on Response to Combination Therapy [0.03%]
药动学和药效学变异对联合治疗反应的差异性影响
Kuteesa R Bisaso,Ronald Kadada Karyaburo,Jackson K Mukonzo et al.
Kuteesa R Bisaso et al.
Interindividual variability (IIV) in drug response complicates both fixed-dose design and individualized therapy. Understanding how pharmacokinetic (PK) and pharmacodynamic (PD) processes jointly shape this variability is essential, particu...
A Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Highly Selective NaV1.8 Inhibitor JKN2306 in Healthy Chinese Subjects [0.03%]
一项I期研究评估选择性钠离子通道NaV1.8抑制剂JNK2306在中国受试者中的安全性、耐受性和药代动力学特征的研究
Ying Yang,Mai Han,Gang Cui et al.
Ying Yang et al.
JKN2306 is a novel, highly selective Nav1.8 inhibitor under development for the treatment of acute pain. This first-in-human study aimed to evaluate its safety, tolerability, pharmacokinetics, and food effect (FE). This was a single center,...
Natural Monoterpene Stylosin Induced Anticancer Effects on Human Colon Carcinoma Cells [0.03%]
天然单萜类化合物stylosin诱导人结肠癌细胞的抗肿瘤效应
Sara Seyedshazileh,Amirabbas Abdollahi,Mehrdad Iranshahi et al.
Sara Seyedshazileh et al.
Colorectal carcinoma (CRC) ranks among the top five most common malignancies globally, characterized by a high incidence and poor prognosis. Hepatocyte growth factor receptor (HGFR), a tyrosine kinase oncoprotein, plays a critical role in t...
A Prospective Study of Marsh PK-PD Model and Schnider PK-PD Model During Anesthesia Induction for Obese Patients Undergoing Elective Heart Surgery [0.03%]
肥胖患者行择期心脏手术麻醉诱导期间Mash PK-PD模型与Schnider PK-PD模型的前瞻性研究
Jianhong Ye,Weina Liang
Jianhong Ye
This prospective study compared the Marsh and Schnider pharmacokinetic models for propofol target-controlled infusion (TCI) during anesthetic induction in obese patients undergoing elective cardiac surgery. A total of 118 patients were rand...
Randomized Controlled Trial
Pharmacology research & perspectives. 2026 Jun;14(3):e70284. DOI:10.1002/prp2.70284 2026
Patterns of Spontaneous Adverse Drug Reaction Reporting in Germany From 2012 to 2021 [0.03%]
2012至2021年德国主动报告的药品不良反应模式
Diana Dubrall,Severin Domgörgen,Patrick Christ et al.
Diana Dubrall et al.
The absolute number of spontaneous adverse drug reaction (ADR) reports increased in the past in several national and international ADR databases. However, in most studies drug exposure was not considered. Our study aimed to evaluate the num...
Virtual Screening and Zebrafish Phenotype-Based Evaluation Argues Against Repurposing 4-Phenylbutyrate for STXBP1-Related Disorders [0.03%]
虚拟筛选和斑马鱼表型评价不支持将4-苯基丁酸重用于STXBP1相关疾病治疗
Aline Frick,Paige Whyte-Fagundes,Scott C Baraban
Aline Frick
Syntaxin-binding protein 1 (STXBP1) mutations lead to severe epilepsy, intellectual disability, developmental delay, and movement disorder. Effective treatments for these conditions do not exist. Recent studies in Munc18-1 (STXBP1) C. elega...
Using a NanoBRET-Based Ligand-Binding Assay at the β2-Adrenoceptor for Undergraduate Pharmacology Education [0.03%]
基于NanoBRET的β2肾上腺素受体配体结合试验在药理学教学中的应用
Abigail Pearce,Xianglin Huang,Theo Redfern-Nichols et al.
Abigail Pearce et al.
The teaching of pharmacology includes a fundamental understanding of ligand binding; how it is measured and how it is calculated. We sought to modernize the techniques by which ligand affinity is determined by undergraduate students and int...