Sex-Dependent Long-Term Neurobehavioral Recovery in Experimental Neonatal Hypoxic-Ischemic Encephalopathy [0.03%]
实验性新生儿缺氧缺血性脑病的性别依赖性的长期神经行为恢复机制研究
Elisa Landucci,Bruno P Imbimbo,Alessia Melani et al.
Elisa Landucci et al.
This study investigates the sex-dependent effects of therapeutic hypothermia and a neuroprotectant (CHF6467) on long-term neurobehavioral recovery in neonatal rats subjected to hypoxic-ischemic encephalopathy. Using the Rice-Vannucci model,...
The Use of Proton Pump Inhibitors Among Adults in Norway-A Nationwide Drug Utilization Study [0.03%]
挪威成人质子泵抑制剂的使用情况——一项全国范围内的药物利用研究
Reidar Fossmark,Sveinung Molnes,Liv Sagatun et al.
Reidar Fossmark et al.
The use of proton pump inhibitors (PPIs) has increased in Western countries over several decades, and there is concern about unsubstantiated indications and effects of long-term use. The study aimed to describe the prevalence, incidence, in...
Safety Monitoring of Colistin Therapy in Critically Ill Neonates With Late-Onset Sepsis: A Retrospective Observational Study [0.03%]
危重 neonate 晚发败血症治疗中多粘菌素安全性监测的回顾性观察研究
Baran Cengiz Arcagok,Akan Yaman,Turkay Rzayev et al.
Baran Cengiz Arcagok et al.
This study aimed to evaluate the safety of colistin therapy by monitoring renal function and electrolyte levels in critically ill neonates with late-onset sepsis (LOS) hospitalized in the neonatal intensive care unit (NICU) between 2015 and...
Observational Study
Pharmacology research & perspectives. 2025 Oct;13(5):e70178. DOI:10.1002/prp2.70178 2025
Pharmacodynamics of Vancomycin Against Coagulase-Negative Staphylococci Bloodstream Infections [0.03%]
万古霉素对凝固酶阴性葡萄球菌败血症的药效学特征分析
Kiera H Harwood,Courtney E Brusamarello,Amanda L Wilkins et al.
Kiera H Harwood et al.
The recommended therapeutic target for vancomycin for serious methicillin-resistant S. aureus infections is an area under the concentration-time curve (AUC) over 24 h to a minimum inhibitory concentration (MIC) ratio of ≥ 400. Its applicab...
Antibiotic Prescribing for Cellulitis in the Absence of Penicillin-Cephalosporin Cross-Reactivity Alerts: A Retrospective Study [0.03%]
一项回顾性研究：缺乏青霉素-头孢菌素交叉过敏警报的蜂窝织炎患者的抗生素处方情况
Milan Sundermann,James A H Mehrtens,Nicholas M Douglas et al.
Milan Sundermann et al.
Cephalosporins are often avoided in patients with penicillin adverse drug reaction (ADR) labels. In our institution's electronic medication management system, penicillin and cephalosporin ADR labels do not generate cross-reactivity alerts. ...
Prevalence and Predictors of Opioid Use Before Spine Surgery: A Multicenter, Cross-Sectional Observational Study [0.03%]
术前使用阿片类药物的患病率和预测因素：一项多中心横断面观察研究
Shania Liu,Jennifer Stevens,Chi Tran et al.
Shania Liu et al.
Spine surgery is performed on 45 000 Australians annually, and opioids are frequently used for pain management before spine surgery, although concerns about their effectiveness and harms persist. Evidence suggests preoperative opioid use is...
The MAO-B Inhibitor Selegiline Reduces the Viability of Different Prostate Cancer Cell Lines and Enhances the Effects of Anti-Androgen and Cytostatic Agents [0.03%]
单胺氧化酶B抑制剂司来吉兰可降低不同前列腺癌细胞系的存活率，并增强抗雄激素和细胞毒性药物的作用
Anita Steib,Krisztina Pohóczky,Norbert Tóth et al.
Anita Steib et al.
The current treatments for advanced prostate adenocarcinoma (PAC) include the androgen receptor antagonist enzalutamide and docetaxel-based chemotherapy. Elevated monoamine oxidase-A (MAO-A) mRNA expression and activity in tumorous prostate...
Cannabinoid-Induced Hyperphagia is Mediated by Increased Meal Frequency and the Orexin-1 Receptor in Male Rats [0.03%]
大麻素通过增加进食次数和下丘脑 orexin-1 受体诱导雄性大鼠过度摄食
Magen N Lord,Grace C Madu,Ana L Loera-Lopez et al.
Magen N Lord et al.
Exogenous cannabinoids have long been known to promote eating. However, the underlying mechanisms have not been completely elucidated, which is critical to understanding their utility. The orexin/hypocretin (OH) system of the lateral hypoth...
Association of Pharmacologic Markers of Anti-Tumor Necrosis Factor-α Activity and Etanercept Effectiveness in Juvenile Idiopathic Arthritis [0.03%]
药物标志物与依那西普治疗幼年特发性关节炎疗效相关性的队列研究
Mudassar I Arain,Kishore Polireddy,Eduardo S Fricovsky et al.
Mudassar I Arain et al.
Therapies targeting tumor necrosis factor-α (TNFα), including etanercept (ETN), have become a mainstay in the treatment of juvenile idiopathic arthritis (JIA). As a result, this work seeks to evaluate the relationship between pharmacologi...
A Comparison of the Molecular Pharmacological Properties of Current Short, Long, and Ultra-Long-Acting β2-Agonists Used for Asthma and COPD [0.03%]
现有短效、长效及超长效β2受体激动剂治疗哮喘和慢阻肺的分子药理学性质比较研究
Richard G W Proudman,Jillian G Baker
Richard G W Proudman
β-agonists have been used in asthma for 120 years. There are two recent changes: ultra-long-acting agonists for COPD and new asthma guidelines recommending formoterol/ICS inhalers phasing out short-acting salbutamol inhalers. Few studies d...
Comparative Study
Pharmacology research & perspectives. 2025 Oct;13(5):e70154. DOI:10.1002/prp2.70154 2025