Effect of Spinacia oleracea on In Vitro Disintegration and Dissolution of Clopidogrel Bisulfate Tablets [0.03%]
菠菜(Spinacia oleracea)对硫酸氯吡格雷片体外崩解和溶出的影响
Dana Sadaqa,Hani A Naseef,Asma Radwan et al.
Dana Sadaqa et al.
Drug-food interactions may compromise therapeutic efficacy, particularly for life-saving medications such as anticoagulants. Changes in gastric fluid properties, including pH modification and surface film formation, can alter drug dissoluti...
Estimation of the Orexin Receptor Occupancy From Human Plasma Pharmacokinetics of Vornorexant, a Novel Dual Orexin 1/2 Receptor Antagonist for the Treatment of Insomnia [0.03%]
基于人类血浆药代动力学估算用于治疗失眠的新型双 orexin 1/2 受体拮抗剂 vrn 德剂量下的 orexin 受体占有率
Shunsuke Kamigaso,Yoshihiro Konno,Hirohiko Hikichi et al.
Shunsuke Kamigaso et al.
Vornorexant is a novel dual orexin receptor antagonist (DORA) for the treatment of insomnia with a short elimination half-life. Estimation of the human orexin receptor occupancy can provide insight into the duration of the sleep-promoting e...
Pharmacokinetics and Customized Dosing of Vancomycin in Adult Patients With Hematological Malignancies: Status, Challenges, and Opportunities [0.03%]
成人血液系统恶性肿瘤患者万古霉素的药代动力学及个体化用药：现状、挑战与机遇
Xiangqing Song,Meizi Zeng,Tao Yang et al.
Xiangqing Song et al.
Vancomycin (VAN) remains the first-line treatment for methicillin-resistant, multidrug-resistant gram-positive bacterial infections, even among cancer patients. Patients with hematological malignancies (HMs) represent a unique population, w...
Exploring Pembrolizumab-Induced IM3OS in a Patient With Bladder Cancer [0.03%]
一例接受帕博利珠单抗治疗的尿路上皮癌患者的免疫介导性三叉神经炎病例报告
Ching-Cheng Chan,Ming-Jen Lee,Jian Su et al.
Ching-Cheng Chan et al.
Pembrolizumab, an immune checkpoint inhibitor (ICI), has transformed cancer treatment across various malignancies, including metastatic urothelial cancer. As the use of pembrolizumab becomes increasingly widespread, understanding its potent...
Advances in Therapeutic Antibody Discovery and Development Targeting G Protein-Coupled Receptors [0.03%]
靶向G蛋白偶联受体的治疗性抗体发现与开发进展
Catherine J Hutchings,Serbülent Ünsal,Mathieu Rappas et al.
Catherine J Hutchings et al.
G protein-coupled receptors (GPCRs) are integral to numerous biological processes and are associated with various diseases across all therapeutic areas. Consequently, GPCRs present substantial potential for antibody-based therapies. This re...
The Risk Factors and Mortality Among Patients With Different Combination Patterns of Opioids and Benzodiazepines: A Retrospective Study [0.03%]
不同阿片类和苯二氮卓类药物联用模式患者的危险因素及死亡率：回顾性研究
Fang-Yu Su,Ming-Che Tsai,Yee-Yung Ng et al.
Fang-Yu Su et al.
The concurrent use of opioids and benzodiazepines (BZDs) has raised safety concerns due to increased risks of respiratory depression and death. To evaluate mortality risks linked to different patterns of co-prescription, we conducted a retr...
Pharmacoepidemiology of Oxycodone in the USA: An Observational Study of ARCOS, Medicaid, and Medicare Drug Databases [0.03%]
美国羟考酮药物流行病学的一项基于ARCOS、医疗补助和 medicare数据库的观察性研究
Jay P Solgama,Apoorva Pradhan,Kenneth L McCall et al.
Jay P Solgama et al.
The US continues to battle an opioid crisis, substantially influenced by prescription opioids, with nearly 80 000 opioid-related deaths in 2023. This study aims to characterize oxycodone's distribution in the United States (US) from 2000 to...
Observational Study
Pharmacology research & perspectives. 2026 Feb;14(1):e70210. DOI:10.1002/prp2.70210 2026
Comparing the Molecular Pharmacological Properties of Existing β-Blockers to Determine the Theoretically Most "Ideal" Anti-Cancer β-Blocker [0.03%]
比较现有的β受体阻滞剂的分子药理学特性以确定理论上最理想的抗肿瘤β受体阻滞剂品种
Jillian G Baker
Jillian G Baker
There is increasing evidence, from cellular, animal and human epidemiological studies, linking β-blockers with reductions in cancer growth and metastasis. Propranolol is the most investigated β-blocker for cancer; although as many differe...
Comparative Study
Pharmacology research & perspectives. 2026 Feb;14(1):e70214. DOI:10.1002/prp2.70214 2026