Enhancing Pharmacology Education Through Collaborative Innovation: The Evolution and Future of PRORENATA at an Engineering-Based Medical Program [0.03%]
合作创新推动药理学教育发展——工程背景医学院校PRORENATA项目实践与展望
Megan A Lim,Diamond Coleman,Noah Nigh et al.
Megan A Lim et al.
Carle Illinois College of Medicine (CI MED), the first engineering-based medical program in the United States, approaches teaching medicine with an engineering innovation mindset. This approach is reflected in PRORENATA, a pioneering web ap...
Pharmacokinetic, Safety, and Immunogenicity Similarity of High- and Low-Concentration Formulations of Adalimumab Biosimilar ABP 501, Adalimumab-Atto [0.03%]
高浓度和低浓度阿达木单抗类似药ABP 501与复方制剂的药代动力学、安全性和免疫原性比较研究：一项随机双盲试验
Vincent Chow,Muhan Zhou,Daniel T Mytych et al.
Vincent Chow et al.
ABP 501, a monoclonal anti-tumor necrosis factor antibody, was the first adalimumab biosimilar approved in the US and EU as a 50 mg/mL formulation. An ABP 501 100 mg/mL high-concentration formulation is also now approved. This study compare...
Randomized Controlled Trial
Pharmacology research & perspectives. 2026 Apr;14(2):e70236. DOI:10.1002/prp2.70236 2026
A Clinically Relevant Drug Interaction Between Busulfan and Rifampin in the Setting of Hematopoietic Stem Cell Transplant Conditioning [0.03%]
布硫磺与利福平在造血干细胞移植预处理中的临床相关药物相互作用
Colleen Drangines,Janet Laquet,Ranju Kunwor
Colleen Drangines
Busulfan is an alkylating agent used in combination with other chemotherapeutic agents and has become a common component of conditioning regimens prior to hematopoietic stem cell transplantation. Busulfan has a very narrow therapeutic index...
Network Pharmacology Combined With Clinical Retrospective Analysis to Investigate the Potential Mechanisms and Clinical Significance of Folate in Treating Spinal Cord Injury [0.03%]
网络药理学结合临床回顾性分析探究叶酸治疗脊髓损伤的潜在机制及临床意义
Xiaolei Chu,Jiajia Liang,Jiaojiao Sun et al.
Xiaolei Chu et al.
Folate is an indispensable nutrient involved in key biological processes, including enzymatic reactions, DNA replication, metabolic regulation, and methylation. Studies indicate that folate promotes neuronal regeneration and repair in patie...
Risk of Major Congenital Malformations Associated With the First-Trimester Exposure to Antipsychotics: A Large Claims Database Study [0.03%]
基于理赔数据库的抗精神病药妊娠风险大型队列研究：孕早期使用抗精神病药物与重大先天畸形之间的关系
Ryo Obara,Takamasa Sakai,Tomofumi Ishikawa et al.
Ryo Obara et al.
This study aimed to evaluate the risk of major congenital malformations (MCMs) associated with first-trimester exposure to antipsychotics, using a large claims database in Japan. This retrospective cohort study was based on data from a larg...
The Effects of SGLT2 Inhibitors on Muscle Health in Older Adults: A Systematic Review and Meta-Analysis [0.03%]
钠葡萄糖协同转运蛋白2抑制剂对老年人肌肉健康的影响：系统评价和 meta 分析
Weena Joongpan,Nittaya Boonmuen,Pimthong Sinchai et al.
Weena Joongpan et al.
Type 2 diabetes mellitus (T2DM) and obesity are growing global health concerns, particularly in older adults who are at higher risk of sarcopenia. While sodium-glucose cotransporter 2 (SGLT2) inhibitors show promise for glycemic control and...
A Machine Learning-Based Model for Individualized Prediction of Vancomycin Concentration-Time Curves in ICU Patients [0.03%]
基于机器学习的预测ICU患者万古霉素浓度-时间曲线的个体化模型
Jing-Yi Wang,Jiang Hu,Yan Chen et al.
Jing-Yi Wang et al.
Therapeutic drug monitoring is essential for ensuring the efficacy and safety of vancomycin therapy in critically ill patients. This study aimed to develop a machine learning model for individualized prediction of vancomycin concentration-t...
Targeting Inflammatory and Oxidative Pathways in Idiopathic Pulmonary Fibrosis: Synergistic Effects of Quercetin and Pirfenidone in Modulating Nrf2/PPAR-γ and TLR-4/NF-κB Pathways [0.03%]
针对特发性肺纤维化炎症和氧化途径的药物联合治疗：槲皮素与吡非尼酮协同调节Nrf2/PPAR-γ和TLR-4/NF-κB信号通路的作用研究
Hanaa Wanas,Amira Karam Khalifa,Hossein M Elbadawy et al.
Hanaa Wanas et al.
Pulmonary fibrosis (PF) is a progressive condition characterized by inflammation and excessive fibrous tissue formation. Pirfenidone, an FDA-approved drug, slows PF progression through reducing TGF-β production and antioxidant effects. Que...
Sheetal D Ullal,Ashima G Thomas,Sahana Devadasa Acharya et al.
Sheetal D Ullal et al.
Epilepsy is a common neurologic disorder; its incidence in childhood is 2.5 per 1000 children. Levetiracetam (LEV) is an antiepileptic drug with a broad spectrum of action used in localized and generalized epilepsies in both adults and chil...
Steroid Recognition in Adhesion GPCRs: A Structural and Pharmacological Perspective [0.03%]
从结构和药理学角度看待类固醇在粘附G蛋白偶联受体中的识别作用
Bethany Fleming,Abdul-Akim Guseinov,Irina G Tikhonova et al.
Bethany Fleming et al.
Emerging evidence suggests steroids may act as generalizable ligands for adhesion GPCRs, a receptor class with considerable pharmacological potential. While most studies have focused on the ADGR'G' subfamily, recent cryo-EM structures of th...