The Novel TRPV1 Agonist ST-6631 Improves Swallowing Function in Rat Models of Stroke-Related Dysphagia and Demonstrates Pharmaceutical Advantage Over Capsaicin, by Exhibiting Minimal Pungent and Irritant Properties [0.03%]
新型TRPV1激动剂ST-6631可改善卒中相关性吞咽障碍模型大鼠的吞咽功能且其作用机制与辣椒素不同，刺激及灼烧感小
Masanori Miyauchi,Hiroyuki Kitano,Mami Kochi et al.
Masanori Miyauchi et al.
Dysphagia, often associated with neurological disorders such as stroke, not only damages patients' quality of life, like the joy of engaging with meals, but also adversely affects mortality among patients by increasing risks of getting aspi...
Clinical-Pharmacological Drug Information Center of Hannover Medical School: Update From a Tertiary Care University Hospital (2022-2024) [0.03%]
汉诺威医学院医学专科医院药物临床药理信息中心（2022-2024）更新报告
Johannes Heck,Dirk O Stichtenoth,Christoph Schröder et al.
Johannes Heck et al.
Drug information centers (DICs) are institutions dedicated to providing independent and up-to-date information on medications and their usage to healthcare professionals. Here, we provide an update from the clinical-pharmacological DIC of H...
Psychedelic Therapies for Comorbid Major Depressive Disorder and Chronic Pain: A Review of Putative Mechanisms of Action [0.03%]
伴发重大抑郁障碍和慢性疼痛的迷幻疗法：潜在作用机制综述
Jordana Kazdan,Karim S Ladha,M Ishrat Husain
Jordana Kazdan
Major Depressive Disorder (MDD) and chronic pain are independently debilitating conditions that frequently co-occur. This comorbidity poses a significant clinical challenge, resulting in greater symptom severity, higher disability, and wors...
Colchicine has Dose-Dependent Therapeutic Effects in a LPS-Induced Experimental Endotoxemia Model [0.03%]
低、中、高剂量秋水仙碱对内毒素血症大鼠的治疗作用及机制研究
Meliksah Demir,Ayse Yesim Gocmen,Esin Ozcelebi et al.
Meliksah Demir et al.
Colchicine is an ancient medication that has long been used for anti-inflammatory properties. Because of unfavorable and toxic consequences of colchicine, selecting an appropriate dose is critical. The effects of three different doses (0.5,...
Improving Population Pharmacokinetic Modelling with Artificial Patients using Generative Artificial Intelligence [0.03%]
利用生成式人工智能改进人群药代动力学模型中的虚拟患者建模
Verena Schöning,Felix Hammann
Verena Schöning
In population pharmacokinetics (PopPK), non-linear mixed effects (NLME) models are used to simultaneously describe a drug's pharmacokinetics (PK) and dynamics (PD) in a patient population using systems of ordinary differential equations. In...
Pharmacological Separation of Mechanosensory Mechanisms in Rat Urinary Bladder Ex Vivo [0.03%]
大鼠离体膀胱感觉传入神经纤维对机械刺激的药理学反应
Igor B Philyppov,Ganna V Sotkis,Semen I Yelyashov et al.
Igor B Philyppov et al.
The local response of the bladder wall to stretch is believed to result from the coordinated activation of mechanosensitive ion channels located in the plasma membrane of the cells that form the wall's urothelial and detrusor smooth muscle ...
Apigenin Protects H9c2 Cells Against Oxygen-Glucose Deprivation/Reperfusion Injury by Regulating Autophagy via the HIF-1α/miR-20a Axis [0.03%]
阿皮根素通过HIF-1α/miR-20a轴调节自噬保护H9c2细胞免受缺氧葡萄糖剥夺/再灌注损伤
Xiaoxu Zhao,Huihui Li,Yi Yuan et al.
Xiaoxu Zhao et al.
As living standards improve and the population ages, cardiovascular disease poses a significant threat to human health. Apigenin, a flavonoid compound found in many fruits and vegetables native to warm climates, is named after celery becaus...
Effect of Interleukin-6 Inhibitors on Rheumatoid Arthritis Pain: Overview of Evidence and Mechanistic Pathways [0.03%]
白细胞介素-6抑制剂对类风湿关节炎疼痛的影响：证据综述及机制途径分析
Andrej Belančić,Seher Sener,Almir Fajkić et al.
Andrej Belančić et al.
Rheumatoid arthritis (RA) is an autoimmune systemic disease in which pain remains a major and often refractory symptom even after clinical remission of the disease. Although historically attributed to joint inflammation, recent evidence rev...
Development and Validation of Pharmacology Concept Inventory for Concept-Based Learning: Leveraging Theory, Expert Insights, and Student Perspectives [0.03%]
基于概念的学习的药理学概念综合评价量规的制订与验证：利用理论、专家见解和学生视角
Adeladlew K Netere,Tony Hughes,Anna-Marie Babey et al.
Adeladlew K Netere et al.
Misconceptions in pharmacology can undermine learning and compromise both clinical and scientific reasoning, yet few validated tools exist to identify them. Consequently, we developed and validated the Pharmacology Concept Inventory (PCI), ...
Excessive Apixaban Concentrations in a Bleeding Patient Treated With Pharmacological Reversal and Extracorporal Removal-A Case Report [0.03%]
药物反向和体外去除治疗下出现艾 Pixaban 过高浓度的出血患者病例报告
Richard Felix Kraus,Johanna Rosenberger,Alexander Dejaco et al.
Richard Felix Kraus et al.
In trauma, even therapeutic apixaban levels can significantly exacerbate bleeding. In cases of overdose, the risk of prolonged, life-threatening hemorrhage increases substantially, necessitating targeted interventions, such as pharmacologic...