Extending Investigations of miR-126-5p on the Regulation of CYP2A6, the Major Nicotine-Inactivating Enzyme [0.03%]
有关miR-126-5p通过调控尼古丁灭活酶CYP2A6的主要酶的调节作用的研究扩展调查
Weilong Gu,Alec W R Langlois,Haidy Giratallah et al.
Weilong Gu et al.
CYP2A6 is the hepatic enzyme responsible for the metabolic inactivation of nicotine. Variation in CYP2A6 alters nicotine clearance, affecting numerous smoking behaviors and tobacco-related diseases, making investigating sources of variation...
Joel Michael,Paul J White
Joel Michael
Core concepts are "big ideas" that can play a number of roles in helping students master a particular discipline: (1) they may define the important content of a discipline, (2) serve as tools to help students gain a better understanding of ...
Aspirin Versus LMWH for Thromboprophylaxis Following Hip or Knee Arthroplasty-Clinical Implications and Budget Impact [0.03%]
阿司匹林与低分子肝素用于髋关节或膝关节置换术后血栓预防的临床意义及经济影响
Eugen Javor,Andrej Belančić,Patrik Javor et al.
Eugen Javor et al.
Venous thromboembolism (VTE) remains a significant concern for patients undergoing hip or knee arthroplasty, with a need to balance effective thromboprophylaxis and bleeding risk. We aimed to compare the efficacy, safety, and budget impact ...
Comparative Study
Pharmacology research & perspectives. 2025 Aug;13(4):e70147. DOI:10.1002/prp2.70147 2025
Pharmacokinetic Variability of Amlodipine Serum Concentration and Effect on Blood Pressure in Patients Treated for Hypertension [0.03%]
氨氯地平血药浓度的药动学变异及其对高血压患者血压的影响
Stine Rognstad,Camilla L Søraas,Cathrine Brunborg et al.
Stine Rognstad et al.
We investigated the effects of age, sex, BMI, total number of prescribed daily pills, common biomarkers, and CYP3A4/5 polymorphisms on dose-adjusted amlodipine concentration (CDR) in hypertensive patients. We also examined associations betw...
Investigation on the Use and Preauthorization of Carbapenems at A National Hospital in Vietnam: A Cross-Sectional Study [0.03%]
越南国家医院碳青霉烯类抗生素使用及用药前审批调查：一项横断面研究
Han Ngoc Bao Pham,Nhi Truc Y Nguyen,Nhu Quynh Tran et al.
Han Ngoc Bao Pham et al.
Carbapenems, known for their broad-spectrum activity and used as last-line treatment for severe drug-resistant infections, are encountering increasing resistance. Therefore, Thong Nhat Hospital, a national hospital in Vietnam, has implement...
Molecular Docking, Dynamics, and Preclinical Studies Reveal Morin Hydrate as a Potent PPARγ and Nrf2 Agonist That Mitigates Colon Inflammation [0.03%]
分子对接、动力学和临床前研究揭示了山柰酚 hydrate 是一种强大的PPARγ和Nrf2激动剂，可缓解结肠炎症
Aya A Touny,Balaji Venkataraman,Saeeda Almarzooqi et al.
Aya A Touny et al.
Peroxisome proliferator-activated receptors (PPARs), functioning as nuclear receptors, regulate the expression of genes associated with inflammation, lipid metabolism, and glucose metabolism. The primary isotypes of PPARs are PPARα, PPARβ...
Lobaric Acid Exhibits Anticancer Potential by Modulating the Wnt/β-Catenin Signaling Pathway in MCF-7 Cells [0.03%]
鬼笔酸通过调节Wnt/β-catenin信号通路发挥抗肿瘤作用
Şeyda Nur Kalın,Kübra Nur Bayındırlı,Emine Toraman et al.
Şeyda Nur Kalın et al.
Lichen secondary metabolites with many remarkable biological activities are used in cancer treatments due to their low side effects and high anticancer potential. In particular, these metabolites constitute an interesting research area in c...
Upadacitinib-Induced Hemolysis in a Patient With Glucose-6-Phosphate Dehydrogenase Deficiency-A Possible Adverse Drug Reaction [0.03%]
葡萄糖-6-磷酸脱氢酶缺乏患者中出现阿布昔替尼引起的溶血：一种可能的药物不良反应
Laura Patanè,Giuseppe Costantino,Marco Muscianisi et al.
Laura Patanè et al.
Glucose-6-phosphate-dehydrogenase (G6PD) deficiency is a heterogenous disorder that may lead to severe hemolytic events with the ingestion of fava beans and exposure to certain drugs. We report the first case of a 65-year-old male with Croh...
Pleiotropic Effects of the NSAID Fenamates on Chloride Channels: Opportunity for Ion Channelopathies? [0.03%]
非甾体抗炎药fenamates的多效性对氯通道的作用：治疗离子通道病的机会？
Paola Laghetti,Ilaria Saltarella,Simone Dell&#x;Atti et al.
Paola Laghetti et al.
Chloride channels are involved in many cellular processes, including cell volume regulation, modulation of cell excitability, and electrolyte and water secretion. Mutations of these proteins are associated with heterogeneous diseases such a...
Caveats of Metronidazole Addition for Surgical Site Infection Prophylaxis in Gynecologic Surgeries [0.03%]
甲硝唑用于妇科手术部位感染预防的注意事项
Minh-Hoang Tran,Kim-Huong Truong-Nguyen
Minh-Hoang Tran