Adrenal βarrestin1 targeting for tobacco-associated cardiac dysfunction treatment: Aldosterone production as the mechanistic link [0.03%]
靶向肾上腺β- arrestin1治疗烟草相关心脏功能障碍的潜在作用机制与醛固酮产生有关
Maria E Solesio,Erna Mitaishvili,Anastasios Lymperopoulos
Maria E Solesio
Tobacco kills 6 million people annually and its global health costs are continuously rising. The main addictive component of every tobacco product is nicotine. Among the mechanisms by which nicotine, and its major metabolite, cotinine, cont...
Inhibiting the immunoproteasome's β5i catalytic activity affects human peripheral blood-derived immune cell viability [0.03%]
抑制免疫蛋白酶体的β5i催化活性会影响人类外周血源性免疫细胞的存活率
Katrien Pletinckx,Silke Vaßen,Ilka Schlusche et al.
Katrien Pletinckx et al.
Small molecule inhibitors selectively targeting the immunoproteasome subunit β5i are currently being developed for the treatment of autoimmune disorders. However, patients carrying loss-of-function mutations in the gene encoding β5i (Psmb...
Exploring the overlapping binding sites of ifenprodil and EVT-101 in GluN2B-containing NMDA receptors using novel chicken embryo forebrain cultures and molecular modeling [0.03%]
利用新型鸡胚胎大脑皮层神经元培养和分子对接研究EVT-101与Ifenprodin在GluN2B-NMDARs的共用结合位点
Marthe F Fjelldal,Thibaud Freyd,Linn M Evenseth et al.
Marthe F Fjelldal et al.
N-methyl-d-aspartate receptors (NMDAR) are widely expressed in the brain. GluN2B subunit-containing NMDARs has recently attracted significant attention as potential pharmacological targets, with emphasis on the functional properties of allo...
Long-term cardiovascular effects of vandetanib and pazopanib in normotensive rats [0.03%]
凡德他尼和帕唑帕尼对正常血压大鼠的长期心血管影响
Samantha L Cooper,Joanne J Carter,Julie March et al.
Samantha L Cooper et al.
Vandetanib and pazopanib are clinically available, multi-targeted inhibitors of vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) receptor tyrosine kinases. Short-term VEGF receptor inhibition is associated...
Application of ultrasound-guided cholecystocentesis to the evaluation of the metabolite profiling in bile of dogs and cynomolgus monkeys [0.03%]
超声引导胆囊穿刺术在评估犬和食蟹猴胆汁代谢产物剖面中的应用
Elizabeth A Dierks,Chiuwa E Luk,Hong Cai et al.
Elizabeth A Dierks et al.
In this study, we describe a novel approach for collecting bile from dogs and cynomolgus monkeys for metabolite profiling, ultrasound-guided cholecystocentesis (UCC). Sampling bile by UCC twice within 24 hours was well tolerated by dogs and...
l-α-Lysophosphatidylinositol (LPI) aggravates myocardial ischemia/reperfusion injury via a GPR55/ROCK-dependent pathway [0.03%]
L-α-溶血磷脂酰肌醇(LPI)通过GPR55/ROCK依赖性途径加重心肌缺血再灌注损伤
Olivia J Robertson-Gray,Sarah K Walsh,Erik Ryberg et al.
Olivia J Robertson-Gray et al.
The phospholipid l-α-lysophosphatidylinositol (LPI), an endogenous ligand for GPR55, is elevated in patients with acute coronary syndrome, and a GPR55 antagonist cannabidiol (CBD) reduces experimental ischemia/reperfusion (I/R) injury. Whi...
A structured literature review of interventions used in the management of nonalcoholic steatohepatitis (NASH) [0.03%]
非酒精性脂肪肝病(NASH)的治疗干预措施的系统评价研究
Manca Povsic,Louisa Oliver,Neha Raju Jiandani et al.
Manca Povsic et al.
Nonalcoholic steatohepatitis (NASH) is a chronic, progressive disease, that can advance to fibrosis, cirrhosis, and hepatocellular carcinoma. Despite being a leading cause of liver transplantation, there are no approved pharmacological trea...
Leucine-rich repeat kinase 2 (LRRK2) inhibitors differentially modulate glutamate release and Serine935 LRRK2 phosphorylation in striatal and cerebrocortical synaptosomes [0.03%]
富含亮氨酸的重复蛋白激酶2(LRRK2)抑制剂对纹状体和脑皮质突触囊泡中谷氨酸释放及丝裂原活化蛋白激酶磷酸化LRRK2 Serine935的调节作用不同
Daniela Mercatelli,Paolo Bolognesi,Martina Frassineti et al.
Daniela Mercatelli et al.
Mutations in leucine-rich repeat kinase 2 (LRRK2) gene have been pathogenically linked to Parkinson's disease, and pharmacological inhibition of LRRK2 is being pursued to tackle nigro-striatal dopaminergic neurodegeneration. However, LRRK2 ...
Histidine-rich glycoprotein augments natural killer cell function by modulating PD-1 expression via CLEC-1B [0.03%]
组氨酸丰富糖蛋白通过CLEC-1B调节PD-1表达来增强自然杀伤细胞的功能
Yoshito Nishimura,Hidenori Wake,Kiyoshi Teshigawara et al.
Yoshito Nishimura et al.
Augmentation of natural killer (NK) cell cytotoxicity is one of the greatest challenges for cancer immunotherapy. Although histidine-rich glycoprotein (HRG), a 75-kDa glycoprotein with various immunomodulatory activities, reportedly elicits...
Preclinical characterization of AMPA receptor potentiator TAK-137 as a therapeutic drug for schizophrenia [0.03%]
AMPA受体增效剂TAK-137的药理机制及其治疗精神分裂症的临床前研究
Maiko Tanaka,Akiyoshi Kunugi,Atsushi Suzuki et al.
Maiko Tanaka et al.
The downregulation of the glutamate system may be involved in positive, negative, and cognitive symptoms of schizophrenia. Through enhanced glutamate signaling, the activation of the α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (A...