Treatment with new organic nitrites in pulmonary hypertension of acute experimental pulmonary embolism [0.03%]
新型有机硝酸酯在急性实验性肺栓塞肺动脉高压治疗中的应用研究
Kristofer F Nilsson,Lars E Gustafsson
Kristofer F Nilsson
Acute pulmonary embolism may cause right heart failure due to increased pulmonary vascular resistance and arterial hypoxemia. Effective vasodilator therapy of the pulmonary hypertension is highly needed. Therefore, we investigated the effec...
Frequency and predictors of the potential overprescribing of antidepressants in elderly residents of a geographically defined U.S. population [0.03%]
美国某一地区老年人潜在过度开具抗抑郁药的状况及其影响因素研究
William V Bobo,Brandon R Grossardt,Maria I Lapid et al.
William V Bobo et al.
The purpose of this study was to estimate the extent of potential antidepressant overprescribing in a geographically defined U.S. population, and to determine the indications and factors that account for it. We conducted a cohort study of n...
Sarah Kern,Ines Truebenbach,Miriam Höhn et al.
Sarah Kern et al.
Pretubulysin (PT), a potent tubulin-binding antitumoral drug, and the well-established antimetabolite methotrexate (MTX) were tested separately or in combination (PT+MTX) for antitumoral activity in L1210 leukemia cells or KB cervix carcino...
Development and validation of PART (Pharmacotherapy Assessment in Renal Transplant Patients) criteria to assess drug-related problems in an outpatient renal transplant population: A cross-sectional study [0.03%]
评估肾移植门诊患者药物相关问题的PART（肾移植患者的药疗评估）标准的制订与验证：横断面研究
Layal El Raichani,Qian Du,Alexandre Mathieu et al.
Layal El Raichani et al.
Kidney transplant recipients are at risk of pharmacological interactions and adverse drug reactions. Community pharmacists are uniquely poised to detect and intervene in cases of drug-related problems. The aims of this study were to develop...
Medical simulation in pharmacology learning and retention: A comparison study with traditional teaching in undergraduate medical students [0.03%]
药学模拟教学在医学生中的应用及效果研究：一项对比研究
Vincenzo Arcoraci,Francesco Squadrito,Domenica Altavilla et al.
Vincenzo Arcoraci et al.
The purpose of the study was to determine whether low-high fidelity medical simulation improves learning and long-lasting retention of pharmacology knowledge, compared to lecture alone, in undergraduate medical students. Ninety students, be...
Comparative Study
Pharmacology research & perspectives. 2019 Jan 9;7(1):e00449. DOI:10.1002/prp2.449 2019
Preclinical tissue distribution and metabolic correlations of vigabatrin, an antiepileptic drug associated with potential use-limiting visual field defects [0.03%]
推荐给药方案下伏隔碱的组织分布和代谢及其与潜在视野缺损的相关性研究
Dana C Walters,Erwin E W Jansen,Garrett R Ainslie et al.
Dana C Walters et al.
Vigabatrin (VGB; (S)-(+)/(R)-(-) 4-aminohex-5-enoic acid), an antiepileptic irreversibly inactivating GABA transaminase (GABA-T), manifests use-limiting ocular toxicity. Hypothesizing that the active S enantiomer of VGB would preferentially...
Diazepam is not a direct allosteric modulator of α1-adrenoceptors, but modulates receptor signaling by inhibiting phosphodiesterase-4 [0.03%]
地西泮不是α1肾上腺素受体的直接别构调节剂，但可通过抑制磷酯酶-4间接调控受体信号通路
Lisa M Williams,Xiaoji He,Tasneem M Vaid et al.
Lisa M Williams et al.
α1A- and α1B-adrenoceptors (ARs) are G protein-coupled receptors (GPCRs) that are activated by adrenaline and noradrenaline to modulate smooth muscle contraction in the periphery, and neuronal outputs in the central nervous system (CNS). ...
Post-MI treatment with G-CSF and EPO-liposome with SLX repairs infarcted myocardium through EPCs mobilization and activation of prosurvival signals in rabbits [0.03%]
载药SLN递送GCSF和EPO治疗心梗后修复心肌的机制研究：基于EPCs动员及促生存信号转导路径在兔模型中的作用研究
Yoshihisa Yamada,Shingo Minatoguchi,Noriko Endo et al.
Yoshihisa Yamada et al.
We investigated whether combination therapy of G-CSF and erythropoietin (EPO)-liposome with Siaryl Lewis X (SLX) is more cardioprotective than G-CSF or EPO-liposome with SLX alone. For the purpose of generating myocardial infarction (MI), r...
MDM2 inhibitor ameliorates cisplatin-induced nephropathy via NFκΒ signal inhibition [0.03%]
MDM2抑制剂通过NFκB信号抑制改善顺铂诱导的肾病
Tomoyuki Fujikura,Hideo Yasuda,Takamasa Iwakura et al.
Tomoyuki Fujikura et al.
Cisplatin is a platinum-containing chemotherapeutic drug, which is widely used and highly effective. While effective against tumors, its use is limited by severe side effects such as nephrotoxicity and bone marrow suppression. Murine double...
Efficacy of SMTP-7, a small-molecule anti-inflammatory thrombolytic, in embolic stroke in monkeys [0.03%]
SMTP-7(一种小分子抗炎溶栓剂)对猕猴栓塞性卒中的疗效研究
Eriko Suzuki,Naoko Nishimura,Tetsuya Yoshikawa et al.
Eriko Suzuki et al.
SMTP-7 (Stachybotrys microspora triprenyl phenol-7) is a small molecule that promotes thrombolysis and suppresses inflammation possibly through plasminogen modulation and soluble epoxide hydrolase (sEH) inhibition, respectively. Here, we de...