Reconsidering Ondansetron for Smoking Cessation: A Call for Renewed Investigation [0.03%]
重新评估昂丹司琼在戒烟中的应用：呼吁开展新一轮的研究调查
Amanda Tam,Zoya Munsar,Douglas J Opler
Amanda Tam
Intermittent and Short-Term Empirical Ruxolitinib Regimen for Steroid-Refractory Flareups of Fibrodysplasia Ossificans Progressiva [0.03%]
间歇性和短期使用鲁索利替尼治疗骨化性纤维发育不良难治性复发的冲击疗法
Rong-Long Chen,Tzu-Hsien Yang,Yun-Hsin Wang et al.
Rong-Long Chen et al.
Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare genetic disorder with inflammation-related flare-ups resulting in catastrophic heterotopic ossification (HO). Janus-associated kinase (JAK) inhibitors may have had a blocking effe...
Intranasal Insulin Mitigates Memory Impairment and Neuroinflammation in a Mouse Model of Hippocampal Aging [0.03%]
鼻内给胰岛素减轻与海马老化小鼠模型相关的记忆损伤和神经炎症
Rajasekar Nagarajan,Han Zhang,Jinrui Lyu et al.
Rajasekar Nagarajan et al.
Aging is a complex process that frequently includes cognitive decline with memory loss. In the hippocampus, the number of somatostatin-positive (Sst+) GABAergic interneurons in the hilar region of the dentate gyrus decreases with age. We pr...
Deciphering the Language of Assessment in Pharmacology Summative Written Assessments [0.03%]
药理学总结性书面评估中的评估语言解读
Róisín Kelly-Laubscher,Caoimhe C Flaherty,Lea Herzel et al.
Róisín Kelly-Laubscher et al.
Success in assessments requires that both the knowledge and processing demands of questions are addressed. The focus of students, however, tends to be on knowledge demands oftentimes failing to address adequately or misinterpreting assessme...
Comprehensive Evaluation of Methanolic Fruits Extract of Jatropha gossypifolia L.: Neuropharmacological, Cytotoxic, Anthelmintic, GC-MS Profiling, and Molecular Docking Studies [0.03%]
Jatropha gossypifolia L.甲醇果实提取物的综合评价：神经药理学、细胞毒性、驱虫剂、GC-MS分析和分子对接研究
Md Arafat,Nusrat Jahan Moon,Mahathir Mohammad et al.
Md Arafat et al.
Jatropha gossypifolia L., a member of the Euphorbiaceae family, has been traditionally used in the treatment of various ailments. However, its neuropharmacological, cytotoxic, and anthelmintic potentials have not been thoroughly investigate...
Ba2+-Induced Vasoconstriction as a Model to Investigate the Dynamin Dependence of Biological Processes Regulating Vascular Tone [0.03%]
Ba²⁺引起的血管收缩作为研究调节血管张力的生物过程依赖于Dynamin的模型
Mariangela Gentile,Alice Panti,Eugenio Paccagnini et al.
Mariangela Gentile et al.
Understanding the mechanisms underpinning vascular smooth muscle contraction, which are critical targets for cardiovascular disease treatment, is essential for developing novel therapeutic agents. Recently, the role of mitochondrial fission...
An In Vitro Calibration Model for Vancomycin Quantification in Brain Extracellular Fluid: Toward Improved Dosing in Postoperative Infections [0.03%]
万古霉素定量脑外液模型：术后感染给药剂量优化
Skaistė Žukaitienė,Ainė Žygaitė,Gabrielė Milkintaitė et al.
Skaistė Žukaitienė et al.
Postoperative central nervous system (CNS) infections are associated with high mortality and present a therapeutic challenge due to limited antibiotic penetration into the brain extracellular fluid (ECF). Vancomycin, frequently used in this...
No Evidence of QTc Interval Prolongation With Baxdrostat Treatment: Concentration-QTc Modeling Assessment [0.03%]
巴德拉司特治疗未发现QTc间期延长的证据：浓度-QTc模型评估
Mikael Sunnåker,Christian Källgren,Joanna Parkinson et al.
Mikael Sunnåker et al.
Baxdrostat is a novel, highly potent, selective, competitive inhibitor of human aldosterone synthase currently under development for the treatment of uncontrolled and resistant hypertension and chronic kidney disease. We assessed the risk o...
Preclinical Evaluation of a Novel Molecule Targeting Nucleoside Homeostasis to Restore Energy Metabolism and Cognitive Function in Alzheimer's Disease [0.03%]
阿尔茨海默病小鼠模型中针对核苷稳态改善能量代谢和认知功能的新型药物分子的药效学评价
Kuo-Chen Wu,Chien-Yu Lin,Thanh Tran et al.
Kuo-Chen Wu et al.
Alzheimer's disease (AD) is the most prevalent cause of dementia, characterized by progressive cognitive decline and cerebral metabolic impairment. Yet, the therapeutic options for addressing the disease pathogenesis are limited. Here, we r...
Comparative Efficacy and Renal Safety of Entecavir and Tenofovir Disoproxil Fumarate in the Treatment of Chronic Hepatitis B: A Retrospective Cohort Study From Vietnam [0.03%]
恩替卡韦和富马酸替诺福韦二吡呋酯治疗慢性乙型肝炎疗效及肾安全性的对比：越南的队列研究
Thong Duy Vo,Han Ngoc Gia Nguyen,Sang The Phan
Thong Duy Vo
Tenofovir disoproxil fumarate (TDF) and entecavir (ETV) are first-line antiviral agents for chronic hepatitis B (CHB), yet comparative real-world data in Southeast Asian populations remain limited. This retrospective cohort study aimed to c...
Comparative Study
Pharmacology research & perspectives. 2025 Oct;13(5):e70177. DOI:10.1002/prp2.70177 2025