Self-assembled ruthenium and osmium nanosystems display a potent anticancer profile by interfering with metabolic activity [0.03%]
钌和锇纳米系统通过干扰代谢活性显示出强大的抗肿瘤特性
Mickaël Marloye,Haider Inam,Connor J Moore et al.
Mickaël Marloye et al.
We disclose novel amphiphilic ruthenium and osmium complexes that auto-assemble into nanomedicines with potent antiproliferative activity by inhibition of mitochondrial respiration. The self-assembling units were rationally designed from th...
Lanmodulin peptides - unravelling the binding of the EF-Hand loop sequences stripped from the structural corset [0.03%]
兰模肽研究：解开EF-hand环序列的结合之谜
Sophie M Gutenthaler,Satoru Tsushima,Robin Steudtner et al.
Sophie M Gutenthaler et al.
Lanmodulin (LanM), a naturally lanthanide (Ln)-binding protein with a remarkable selectivity for Lns over Ca(ii) and affinities in the picomolar range, is an attractive target to address challenges in Ln separation. Why LanM has such a high...
Heptadentate chelates for 89Zr-radiolabelling of monoclonal antibodies [0.03%]
用于单克隆抗体放射标记的含89Zr的七齿配体螯合物
Amaury Guillou,Ali Ouadi,Jason P Holland
Amaury Guillou
Herein, we report the synthesis of three new bifunctional heptadentate metal ion binding chelates derived from desferrioxamine B (DFO) linked to a tripeptide unit that comprises of a glutamic acid and two glycine residues. The three DFO der...
Solution- and gas-phase behavior of decavanadate: implications for mass spectrometric analysis of redox-active polyoxidometalates [0.03%]
多氧杂多化合物的氧化还原性质对其质谱行为的影响——十二钒酸盐案例研究
Daniel Favre,Cedric E Bobst,Stephen J Eyles et al.
Daniel Favre et al.
Decavanadate (V10O28 6- or V10) is a paradigmatic member of the polyoxidometalate (POM) family, which has been attracting much attention within both materials/inorganic and biomedical communities due to its unique structural and electrochem...
Induced fit activity-based sensing: a mechanistic study of pyrophosphate detection with a "flexible" Fe-salen complex [0.03%]
诱导拟合活性基传感：具有“柔性”的Fe-salen复合物检测焦磷酸盐的机理研究
Prerna Yadav,Olivier Blacque,Andreas Roodt et al.
Prerna Yadav et al.
Activity-based sensing of biological targets is attracting increasing attention. In this work, we report detailed UV-Vis and fluorescence mechanistic studies on an Fe-salen based probe, [FeIII{salenMeCl2(SO3)2}OH2]- for pyrophosphate (PPi) ...
Induction of immunogenic cell death in cancer cells by a photoactivated platinum(IV) prodrug [0.03%]
光活化铂(IV)前药在癌细胞中诱导免疫原性细胞死亡
Vojtech Novohradsky,Jitka Pracharova,Jana Kasparkova et al.
Vojtech Novohradsky et al.
The platinum(IV) prodrug trans,trans,trans-[Pt(N3)2(OH)2(py)2] (1) is stable and non-toxic in the dark, but potently cytotoxic to cancer cells when irradiated by visible light, including cisplatin-resistant cells. On irradiation with visibl...
Marlene Mathuber,Michael Gutmann,Mery La Franca et al.
Marlene Mathuber et al.
Receptor tyrosine kinase inhibitors have become a central part of modern targeted cancer therapy. However, their curative potential is distinctly limited by both rapid resistance development and severe adverse effects. Consequently, tumor-s...
Axial functionalisation of photoactive diazido platinum(iv) anticancer complexes [0.03%]
轴向官能团化光活性三氮杂铂(IV)抗肿瘤配合物
Huayun Shi,Cinzia Imberti,Guy J Clarkson et al.
Huayun Shi et al.
Mono-axial functionalised octahedral diazido Pt(iv) complexes trans, trans, trans-[Pt(py)2(N3)2(OR1)(OR2)] (OR1 = OH and OR2 = anticancer agent coumarin-3 carboxylate (cou, 2a), pyruvate dehydrogenase kinase (PDK) inhibitors 4-phenylbutyrat...
Redox activity of a dissymmetric ligand bridging divalent ytter-bium and reactive nickel fragments [0.03%]
连接二价稀土钇和反应性镍片段的不对称配体的氧化还原活性
Ding Wang,Maxime Tricoire,Valeriu Cemortan et al.
Ding Wang et al.
The reaction of a reactive nickel dimethyl 1 bearing a redox-active, dissymmetric ligand, which is obtained by deprotonation of 2-pyrimidin-2-yl-1H-benzimidazole (Hbimpm) with a divalent lanthanide complex, Cp*2Yb(OEt2), affords an unpreced...
Green Synthesis of Zr-Based Metal-Organic Framework Hydrogel Composites and Their Enhanced Adsorptive Properties [0.03%]
基于锆的金属有机骨架水凝胶复合材料的绿色合成及其增强吸附性能
Shirell E Klein,Joshua D Sosa,Alexander C Castonguay et al.
Shirell E Klein et al.
Metal-organic frameworks (MOFs) have emerged as promising candidates for a wide range of applications due to their high surface area and customizable structures, however, the minimal external hydrophilicity of MOFs has limited their biomedi...