A ferrocene-containing analogue of the MCU inhibitor Ru265 with increased cell permeability [0.03%]
一种具有增加细胞通透性的类似物MCU抑制剂Ru265的含铁ocene化合物
Zhouyang Huang,Jesse A Spivey,Samantha N MacMillan et al.
Zhouyang Huang et al.
The mitochondrial calcium uniporter (MCU) is a transmembrane protein that mediates mitochondrial calcium (mCa2+) uptake. Inhibitors of the MCU are of interest for their applications as tools to study the role of mCa2+ uptake on cellular fun...
Rational design of metal-organic frameworks (MOFs) as hosts for nanoparticles in catalytic applications: concepts, strategies, and emerging trends [0.03%]
用于催化应用的金属有机框架（MOF）宿主中纳米颗粒的合理设计：概念，策略和新兴趋势
Monnaya Chalermnon,Sophie R Thomas,Jia Min Chin et al.
Monnaya Chalermnon et al.
Metal-organic frameworks (MOFs) are a versatile class of porous coordination materials that have found widespread application in various fields, particularly as heterogeneous catalysts. Due to the modular nature and molecular tunability of ...
Speciation and structural transformation of a VV-malate complex in the absence and in the presence of a protein: from a dinuclear species to decavanadate [0.03%]
缺蛋白质和存在蛋白质时VV-苹果酸复合物的物种形成及结构转化：从双核到十面体钒簇
Maddalena Paolillo,Giarita Ferraro,Nadiia I Gumerova et al.
Maddalena Paolillo et al.
A strategy for the development of new vanadium-based drugs is the preparation of complexes that target proteins and bear molecules involved in the cellular metabolism as ligands, like α-hydroxycarboxylic acids. Based on these premises, thi...
Understanding Structural Isomerism in Organoiridium Picolinamidate Complexes and its Consequences on Reactivity and Biological Properties [0.03%]
organoiridium picolinamidate 复杂的结构异构现象及其对反应性和生物性质的影响理解
Hieu D Nguyen,Croix J Laconsay,Rahul D Jana et al.
Hieu D Nguyen et al.
Organoiridium picolinamidate complexes are promising for intracellular applications because of their biocompatibility, activity in living systems, and ease of derivatization. To shield their metal centers from inhibition by biological nucle...
Structural variations in the trans-carboxylate/chlorido axis that impact the mode of action of Pt(ii) complexes [0.03%]
反式羧酸盐/氯化物轴的结构变异影响Pt(II)配合物的作用模式
David Fabra,Theresa Mendrina,Ana I Matesanz et al.
David Fabra et al.
The design of trans-platinum(ii) complexes marked a significant turning point in the development of unconventional anticancer metallodrugs. Compared to cisplatin, these complexes induce distinctly different cellular responses and are often ...
Magneto-chiral dichroism in a chiral twistacene ytterbium(iii) one-dimensional assembly of single-molecule magnets [0.03%]
手性扭烯基稀土单链磁体中手性磁旋光效应的研究
Israa Shioukhi,Langit Cahya Adi,Vincent Dorcet et al.
Israa Shioukhi et al.
Here we report on one-dimensional nano objects of formula [Yb(hfac)3(M-or P-Ant-C8)] n where the Ant-C8 moiety refers to enantiopure M- and P-twistacenes decorated at positions 2,6 with 4-pyridyl-ethynyl units and helically locked into an e...
Martijn Dijkstra,Michael Gutmann,Mathias Gradl et al.
Martijn Dijkstra et al.
The anticancer platinum complex oxaliplatin exerts its activity through DNA damage and immune-stimulatory mechanisms, but is associated with adverse treatment side effects. Platinum(iv) complexes represent a promising prodrug strategy to im...
Probing the influence of imidazolylidene- and triazolylidene-based carbenes on the catalytic potential of dioxomolybdenum and dioxotungsten complexes in deoxygenation catalysis [0.03%]
咪唑和三唑基叠氮鎓对二氧杂钼和二氧杂钨复合物脱氧催化潜能的影响研究
Florian R Neururer,Florian Heim,Marc Baltrun et al.
Florian R Neururer et al.
We report the synthesis of dianionic OCO-supported NHC and MIC complexes of molybdenum and tungsten with the general formula (OCO)MO2 (OCO = bis-phenolate benzimidazolylidene M = Mo (1-Mo), bis-phenolate triazolylidene M = Mo (2-Mo), M = W ...
A new fluorescent oxaliplatin(iv) complex with EGFR-inhibiting properties for the treatment of drug-resistant cancer cells [0.03%]
一种新型的荧光氧化铂(IV)复合物具有EGFR抑制性能可治疗耐药性癌细胞
Monika Caban,Philipp Fronik,Alessio Terenzi et al.
Monika Caban et al.
Platinum chemotherapy is part of every second anticancer treatment regimen. However, its application is limited by severe side effects and drug resistance. The combination of platinum-based chemotherapeutics with EGFR inhibitors has shown r...
A novel cerium-based metal-organic framework supported Pd catalyst for semi-hydrogenation of phenylacetylene [0.03%]
一种新型铈基金属有机骨架负载Pd催化苯乙炔半氢化反应
Xiangdi Zeng,Zi Wang,Meng He et al.
Xiangdi Zeng et al.
Phenylacetylene is a detrimental impurity in the polymerisation of styrene, capable of poisoning catalysts even at ppm levels and significantly degrading the quality of polystyrene. The semi-hydrogenation of phenylacetylene to styrene inste...