Tetrazine- trans-cyclooctene ligated lanthanide conjugates for biomedical imaging [0.03%]
用于生物医学成像的四氮唑-反式环辛烯型稀土配合物
Hongxuan Chen,William Lim Kee Chang,Grace T McMullon et al.
Hongxuan Chen et al.
Lanthanide chelates and copper-free 'click' chemistry have important uses for targeted molecular imaging and therapeutic strategies. Herein, we report the complexation of lanthanides to a tetrazine-functionalised DO3A macrocyclic chelator a...
Fat or flat? The impact of dipole moment vectors on non-covalent interactions between aromatic tags and macromolecules [0.03%]
扁平或丰满？偶极矩矢量对芳香族标签与大分子之间非共价相互作用的影响
Josef Holub,Adéla Jílková,Carina Lemke et al.
Josef Holub et al.
The closo-1,2-C2B10H12 carborane is a recognized 3D aromatic icosahedral building block, with an electron distribution governed by the outer hydridic BH and acidic CH vertices. We attached the carborane cage to a peptidomimetic scaffold to ...
Mass spectrometric imaging and quantitative analysis of the in vivo biodistribution of trastuzumab using a rhodium(iii) sarcophagine complex [0.03%]
采用铑(III)唾廓环配合物对曲妥珠单抗进行体内分布的质谱图成像及定量分析研究
Natasha Patel,Truc T Pham,Arshiya Banu et al.
Natasha Patel et al.
Mass cytometry with antibodies labelled with stable metal isotopes enables both sensitive imaging and the quantification of protein expression in biological samples. Typically, these specimens are exposed to a panel of labelled antibodies e...
Steen H Hansen,Christian D Buch,Bela E Bode et al.
Steen H Hansen et al.
We herein demonstrate the synthesis of a pair of enantiomerically pure YbIII complexes by post-functionalisation of the parent YbIII complex via condensation with an enantiomerically pure chiral amine. The enantiomeric pair is structurally ...
A ferrocene-containing analogue of the MCU inhibitor Ru265 with increased cell permeability [0.03%]
一种具有增加细胞通透性的类似物MCU抑制剂Ru265的含铁ocene化合物
Zhouyang Huang,Jesse A Spivey,Samantha N MacMillan et al.
Zhouyang Huang et al.
The mitochondrial calcium uniporter (MCU) is a transmembrane protein that mediates mitochondrial calcium (mCa2+) uptake. Inhibitors of the MCU are of interest for their applications as tools to study the role of mCa2+ uptake on cellular fun...
Rational design of metal-organic frameworks (MOFs) as hosts for nanoparticles in catalytic applications: concepts, strategies, and emerging trends [0.03%]
用于催化应用的金属有机框架（MOF）宿主中纳米颗粒的合理设计：概念，策略和新兴趋势
Monnaya Chalermnon,Sophie R Thomas,Jia Min Chin et al.
Monnaya Chalermnon et al.
Metal-organic frameworks (MOFs) are a versatile class of porous coordination materials that have found widespread application in various fields, particularly as heterogeneous catalysts. Due to the modular nature and molecular tunability of ...
Speciation and structural transformation of a VV-malate complex in the absence and in the presence of a protein: from a dinuclear species to decavanadate [0.03%]
缺蛋白质和存在蛋白质时VV-苹果酸复合物的物种形成及结构转化：从双核到十面体钒簇
Maddalena Paolillo,Giarita Ferraro,Nadiia I Gumerova et al.
Maddalena Paolillo et al.
A strategy for the development of new vanadium-based drugs is the preparation of complexes that target proteins and bear molecules involved in the cellular metabolism as ligands, like α-hydroxycarboxylic acids. Based on these premises, thi...
Understanding Structural Isomerism in Organoiridium Picolinamidate Complexes and its Consequences on Reactivity and Biological Properties [0.03%]
organoiridium picolinamidate 复杂的结构异构现象及其对反应性和生物性质的影响理解
Hieu D Nguyen,Croix J Laconsay,Rahul D Jana et al.
Hieu D Nguyen et al.
Organoiridium picolinamidate complexes are promising for intracellular applications because of their biocompatibility, activity in living systems, and ease of derivatization. To shield their metal centers from inhibition by biological nucle...
Structural variations in the trans-carboxylate/chlorido axis that impact the mode of action of Pt(ii) complexes [0.03%]
反式羧酸盐/氯化物轴的结构变异影响Pt(II)配合物的作用模式
David Fabra,Theresa Mendrina,Ana I Matesanz et al.
David Fabra et al.
The design of trans-platinum(ii) complexes marked a significant turning point in the development of unconventional anticancer metallodrugs. Compared to cisplatin, these complexes induce distinctly different cellular responses and are often ...
Magneto-chiral dichroism in a chiral twistacene ytterbium(iii) one-dimensional assembly of single-molecule magnets [0.03%]
手性扭烯基稀土单链磁体中手性磁旋光效应的研究
Israa Shioukhi,Langit Cahya Adi,Vincent Dorcet et al.
Israa Shioukhi et al.
Here we report on one-dimensional nano objects of formula [Yb(hfac)3(M-or P-Ant-C8)] n where the Ant-C8 moiety refers to enantiopure M- and P-twistacenes decorated at positions 2,6 with 4-pyridyl-ethynyl units and helically locked into an e...