Crystallographic and EPR-based characterisation of Cu2+-binding to serum albumin: ATCUN coordination and additional sites [0.03%]
铜离子与血清白蛋白结合的晶体学及EPR研究：ATCUN配位及其他位点
Michal Gucwa,Katarzyna B Handing,Vanessa Bijak et al.
Michal Gucwa et al.
Copper homeostasis is essential for mammalian physiology. Serum albumin plays an important role in plasma copper transport and buffering, yet its Cu2+ binding sites have remained incompletely characterised. Here we report the first X-ray cr...
Structural insights into ortho-aminophenol oxidases: kinetic and crystallographic characterization of Sm NspF and Sg GriF [0.03%]
关于间氨基酚氧化酶的结构洞察：Sm NspF和Sg GriF的晶体学及动力学表征
Hoa Le Xuan,Annette Rompel
Hoa Le Xuan
Actinobacteria-derived o-aminophenol oxidases (AOs) represent a largely unexplored subclass of type-III copper enzymes with catalytic properties distinct from tyrosinases and catechol oxidases. The determination of the first crystal structu...
Competitive LC-MS/MS assay to investigate protein metalation dynamics [0.03%]
竞争性LC-MS/MS测定用于研究蛋白质金属化动力学
Kira Küssner,Michael Wolf,Andrea Cucchiaro et al.
Kira Küssner et al.
Knowledge gaps in the biospeciation of potential metallodrugs may lead to the generalized assumption of their promiscuous reactivity and inherent toxicity, neglecting their pharmaceutical potential. Herein, we developed a rapid and competit...
Lewis superacids for catalytic reductions of stronger element-oxygen double bonds with hydrosilanes [0.03%]
路易斯超强酸促进硅氢化合物对更强的元素-氧双键的催化还原反应
Daniel Franz,Thomas R Frost,Sebastian Stigler et al.
Daniel Franz et al.
The main-group Lewis superacid complexes (pinF)2Si·MeCN (1·MeCN) and (pinF)2Ge·MeCN (2·MeCN) were successfully applied as promoters in the catalytic reduction of phosphine oxides (e.g., Me3PO, Bu3PO, and Ph3PO), a sulfoxide (i.e., Me2SO...
Tetrazine- trans-cyclooctene ligated lanthanide conjugates for biomedical imaging [0.03%]
用于生物医学成像的四氮唑-反式环辛烯型稀土配合物
Hongxuan Chen,William Lim Kee Chang,Grace T McMullon et al.
Hongxuan Chen et al.
Lanthanide chelates and copper-free 'click' chemistry have important uses for targeted molecular imaging and therapeutic strategies. Herein, we report the complexation of lanthanides to a tetrazine-functionalised DO3A macrocyclic chelator a...
Fat or flat? The impact of dipole moment vectors on non-covalent interactions between aromatic tags and macromolecules [0.03%]
扁平或丰满？偶极矩矢量对芳香族标签与大分子之间非共价相互作用的影响
Josef Holub,Adéla Jílková,Carina Lemke et al.
Josef Holub et al.
The closo-1,2-C2B10H12 carborane is a recognized 3D aromatic icosahedral building block, with an electron distribution governed by the outer hydridic BH and acidic CH vertices. We attached the carborane cage to a peptidomimetic scaffold to ...
Mass spectrometric imaging and quantitative analysis of the in vivo biodistribution of trastuzumab using a rhodium(iii) sarcophagine complex [0.03%]
采用铑(III)唾廓环配合物对曲妥珠单抗进行体内分布的质谱图成像及定量分析研究
Natasha Patel,Truc T Pham,Arshiya Banu et al.
Natasha Patel et al.
Mass cytometry with antibodies labelled with stable metal isotopes enables both sensitive imaging and the quantification of protein expression in biological samples. Typically, these specimens are exposed to a panel of labelled antibodies e...
Steen H Hansen,Christian D Buch,Bela E Bode et al.
Steen H Hansen et al.
We herein demonstrate the synthesis of a pair of enantiomerically pure YbIII complexes by post-functionalisation of the parent YbIII complex via condensation with an enantiomerically pure chiral amine. The enantiomeric pair is structurally ...
A ferrocene-containing analogue of the MCU inhibitor Ru265 with increased cell permeability [0.03%]
一种具有增加细胞通透性的类似物MCU抑制剂Ru265的含铁ocene化合物
Zhouyang Huang,Jesse A Spivey,Samantha N MacMillan et al.
Zhouyang Huang et al.
The mitochondrial calcium uniporter (MCU) is a transmembrane protein that mediates mitochondrial calcium (mCa2+) uptake. Inhibitors of the MCU are of interest for their applications as tools to study the role of mCa2+ uptake on cellular fun...
Rational design of metal-organic frameworks (MOFs) as hosts for nanoparticles in catalytic applications: concepts, strategies, and emerging trends [0.03%]
用于催化应用的金属有机框架（MOF）宿主中纳米颗粒的合理设计：概念，策略和新兴趋势
Monnaya Chalermnon,Sophie R Thomas,Jia Min Chin et al.
Monnaya Chalermnon et al.
Metal-organic frameworks (MOFs) are a versatile class of porous coordination materials that have found widespread application in various fields, particularly as heterogeneous catalysts. Due to the modular nature and molecular tunability of ...