A novel melanoma therapy stirs up a storm: ipilimumab-induced thyrotoxicosis [0.03%]
一种新型黑色素瘤疗法引发的风暴：伊匹单抗致甲状腺功能亢进症病例报告
Christine Yu,Inder J Chopra,Edward Ha
Christine Yu
Ipilimumab, a novel therapy for metastatic melanoma, inhibits cytotoxic T-lymphocyte apoptosis, causing both antitumor activity and significant autoimmunity, including autoimmune thyroiditis. Steroids are frequently used in treatment of imm...
Xanthogranulomatous hypophysitis: a rare and often mistaken pituitary lesion [0.03%]
罕见且常被误诊的垂体炎的一种特殊类型——垂体肉芽肿性炎症
Jaya Sujatha Gopal-Kothandapani,Veejay Bagga,Stephen B Wharton et al.
Jaya Sujatha Gopal-Kothandapani et al.
Xanthogranulomatous hypophysitis (XGH) is a very rare form of pituitary hypophysitis that may present both clinically and radiologically as a neoplastic lesion. It may either be primary with an autoimmune aetiology and can occur in isolatio...
Recovery from alopecia areata in a patient with autoimmune polyglandular syndrome type 3 [0.03%]
自身免疫性多腺体综合征Ⅲ型伴圆斑秃的恢复
Shinya Makino,Takeshi Uchihashi,Yasuo Kataoka et al.
Shinya Makino et al.
Recovery from alopecia is rare in autoimmune polyglandular syndrome (APS). A 41-year-old male was admitted to our hospital with hyperglycemia. He developed alopecia areata (AA) 5 months before admission and developed thirst, polyuria, and a...
Functional parathyroid cyst in a patient with systemic lupus erythematosus: a case report [0.03%]
系统性红斑狼疮患者的甲状腺旁功能囊肿1例报告
Jingjing Jiang,Mei Zhang,Ronghua He et al.
Jingjing Jiang et al.
Functional parathyroid cysts are a rare cause of primary hyperparathyroidism and are often mistaken for thyroid cysts. Systemic lupus erythematosus (SLE) is also a very rare cause of hypercalcemia. We report the case of a 62-year-old woman,...
Prolonged life-threatening hypoglycaemia following dose escalation of octreotide LAR in a patient with malignant polysecreting pancreatic neuroendocrine tumour [0.03%]
恶性和多分泌性胰腺神经内分泌肿瘤患者长期重度低血糖反应_octreotide-LAR剂量递增后的个例报告
Sally K Abell,Jessie Teng,Anthony Dowling et al.
Sally K Abell et al.
This paper details the case of a 77-year-old male with refractory hypoglycaemia due to inoperable metastatic pancreatic neuroendocrine tumour (pNET) co-secreting insulin and gastrin. Multiple medical therapies were trialled with limited suc...
Recurrent pituitary apoplexy due to two successive neoplasms presenting with ocular paresis and epistaxis [0.03%]
继发于两个连续肿瘤的眼肌麻痹和鼻出血的垂体卒中反复发作的一例报告
Stephanie Teasdale,Fahid Hashem,Sarah Olson et al.
Stephanie Teasdale et al.
A case of recurrent pituitary apoplexy is described in a 72-year-old man who initially presented with haemorrhage in a non-functioning pituitary adenoma. Five years later, he re-presented with a severe pituitary haemorrhage in an enlarging ...
Large testicular adrenal rest tumours in a patient with congenital adrenal hyperplasia [0.03%]
先天性肾上腺增生患者的大型睾丸肾上腺残余肿瘤
J Rajkanna,S O Oyibo
J Rajkanna
Testicular adrenal rest tumours (TARTs) are benign ACTH-dependent tumours that occur in males with congenital adrenal hyperplasia (CAH) and if left untreated can destroy testicular tissue. Corticosteroid suppressive treatment could result i...
An unusual case of an ACTH-secreting macroadenoma with a germline variant in the aryl hydrocarbon receptor-interacting protein (AIP) gene [0.03%]
芳香烃受体相互作用蛋白(AIP)基因种系变异的ACTH分泌大腺瘤一例报告
Pia T Dinesen,Jakob Dal,Plamena Gabrovska et al.
Pia T Dinesen et al.
A patient of Cushing's disease (CD) characterized by a large tumor and only subtle symptoms of hormonal hypersecretion was examined. The patient had a germline variant in the aryl hydrocarbon receptor-interacting protein (AIP) gene. A 50-ye...
Suspension of basal insulin to avoid hypoglycemia in type 1 diabetes treated with insulin pump [0.03%]
1型糖尿病泵治疗回避低血糖的方法——暂停基础胰岛素剂量
Mauro Boronat,Rosa M Sánchez-Hernández,Julia Rodríguez-Cordero et al.
Mauro Boronat et al.
Treatment with continuous s.c. insulin infusion (CSII) provides better glycemic control and lower risk of hypoglycemia than conventional therapy with multiple daily insulin injections. These benefits have been related to a more reliable abs...
Thyrotoxicosis with absence of clinical features of acromegaly in a TSH- and GH-secreting, invasive pituitary macroadenoma [0.03%]
一种促甲状腺激素和生长激素分泌的侵袭性垂体大腺瘤所致毒性腺瘤(无肢端肥大症临床特点)
Philip C Johnston,Amir H Hamrahian,Richard A Prayson et al.
Philip C Johnston et al.
A 54-year-old woman presented with bi-temporal hemianopia, palpitations, and diaphoresis. An invasive pituitary macroadenoma was discovered. The patient had biochemical evidence of secondary hyperthyroidism and GH excess; however, she did n...