Standardized low-flow ventilation with PEEP maintenance during bronchoscopy in mechanically ventilated ICU patients: a pilot trial [0.03%]
低流量通气联合PEEP维持在机械通气ICU患者支气管镜检查中的应用研究试点试验
Jordan Uguet,Charles-Hervé Vacheron,Margot Bonnet et al.
Jordan Uguet et al.
Background: Fiberoptic bronchoscopy in mechanically ventilated ICU patients can markedly increase airway resistance and peak inspiratory pressure (PIP), limit effective tidal volume delivery, and provoke transient hypoxem...
Diagnostic performance of package insert-based screening for potential drug-drug interactions in ICU patients receiving injectable medications: a retrospective diagnostic accuracy study using Lexi-Interact as the comparator in Japan [0.03%]
基于药品说明书的潜在药物相互作用筛查诊断性能：在重症监护病房接受注射给药患者的回顾性诊断准确性研究（以Lexi-Interact为比较标准）（日本）
Takahiro Kato,Noriko Yasukawa,Eriko Uno et al.
Takahiro Kato et al.
Background: No established gold standard exists for identifying potential drug-drug interactions (pDDIs). In Japan, package inserts are commonly used for pDDI screening in clinical practice, whereas internationally curate...
Feasibility of a nurse-led patch-type electroencephalography monitoring protocol with arterial spin labeling in patients with severe traumatic brain injury: a prospective observational study [0.03%]
护士主导的使用动脉自旋标记技术的严重创伤性脑损伤患者贴片式脑电监测方案可行性研究：前瞻性观察研究
Masahiro Asami,Hikaru Nakata,Ryoichiro Kondo et al.
Masahiro Asami et al.
Nonconvulsive seizures are clinically important in severe traumatic brain injury but are difficult to detect when continuous electroencephalography (EEG) is not feasible in the intensive care unit. We conducted a prospective observational s...
Dose-response relationship of early out-of-bed mobilization with functional decline and adverse events in patients after cardiovascular surgery requiring prolonged intensive care: a retrospective cohort study [0.03%]
早期过早下床活动与心血管手术后需要长期重症监护的功能下降和不良事件的剂量反应关系：回顾性队列研究
Kotaro Hirakawa,Kentaro Kamiya,Hiromichi Ueki et al.
Kotaro Hirakawa et al.
Background: Patients requiring prolonged ICU care after cardiovascular surgery are at high risk of functional decline, yet the optimal mobilization dose remains unclear. This study examined the associations between mobili...
Association between organ dysfunction during ICU stay and post-intensive care syndrome at 1 year after ICU discharge: a prospective cohort study [0.03%]
ICU住院期间器官功能障碍与重症监护出院后1年发生的术后重症综合征的相关性：前瞻性队列研究
Mahan Sadjadi,Matteo Marcello,Miles Drammeh et al.
Mahan Sadjadi et al.
Background: Post-Intensive Care Syndrome (PICS) affects a substantial proportion of intensive care unit (ICU) survivors. This study investigates whether granular features of the ICU course including organ dysfunction are ...
The new SOFA for sepsis identification and mortality prediction: a multicenter cohort study [0.03%]
用于脓毒症识别和死亡率预测的新SOFA评分：一项多中心队列研究
Lina Zhao,Qian Cui,Jie Liu et al.
Lina Zhao et al.
Background: The Sequential Organ Failure Assessment (SOFA) score is central to Sepsis-3 criteria. SOFA-2 updates thresholds and incorporates contemporary organ support practices, but its impact on sepsis identification an...
Development of a deep-learning model for classification of intensivists' extubation decisions using ventilator graphic monitor images: a prospective observational study [0.03%]
深度学习模型的开发用于分类重症监护医师的拔管决策：一项前瞻性观察研究
Tatsuya Hayasaka,Masaki Nakane,Yuka Fujiwara et al.
Tatsuya Hayasaka et al.
Background: Timely extubation requires advanced expertise and extensive clinical experience; however, intensive care specialists are scarce globally, and interpreting ventilator graphic monitor waveforms can be challengin...
The balance between classical and alternative renin-angiotensin system in ARDS: a narrative review [0.03%]
ARDS中经典与非经典的肾素血管紧张素系统平衡：综述文章
Carlotta Dragoni,Irene Sbaraini Zernini,Alberto Calabrese et al.
Carlotta Dragoni et al.
Acute respiratory distress syndrome (ARDS) is a complex inflammatory condition often requiring admission to intensive care. The renin-angiotensin system (RAS) has emerged as a key modulator of lung inflammation, vascular tone, permeability ...
A cumulative-morbidity plasma proteomic architecture of critical-illness susceptibility: a UK biobank proteome-wide study of critical-care exposure, in-hospital death, and sex-specific signals [0.03%]
慢性病的血浆蛋白质组学特征与重症监护易感性关联：英国生物银行广义蛋白质组学研究发现重症监护、院内死亡和性别差异信号
Xingxing Ren,Qingxia Dai,Chaoyuan Jin
Xingxing Ren
Background: Existing biomarker studies profile plasma during acute illness, leaving pre-illness proteomic susceptibility to critical care largely uncharacterised. We mapped the baseline proteomic architecture of critical-...
Response to "Predicting high-flow nasal cannula failure: beyond static indices toward dynamic physiologic assessment" [0.03%]
对“预测高流量鼻导管治疗失败：从静态指标到动态生理评估”的回应
Yaxiaerjiang Muhetaer,Shi-Min Zhang,Amanguli Moming et al.
Yaxiaerjiang Muhetaer et al.