Drug sequestration and metabolite formation: key pharmacokinetic challenges for levosimendan use during ECMO support in cardiogenic shock [0.03%]
Nicolas Tebib,Lucas Liaudet,Zied Ltaief
Nicolas Tebib
Background: In patients with refractory cardiogenic shock, veno-arterial extracorporeal membrane oxygenation (ECMO) provides temporary circulatory support, but optimal strategies to promote myocardial recovery and facilit...
Effect modification by chronic kidney disease on renal outcomes in septic shock patients undergoing high-MAP targeting: a secondary analysis of the OPTPRESS trial [0.03%]
慢性肾脏病对脓毒性休克患者高压目标导向治疗肾预后影响的二次分析：OPTPRESS试验结果
Hiraaki Okuzawa,Akira Endo,Tomohiro Akutsu et al.
Hiraaki Okuzawa et al.
Background: The optimal mean arterial pressure (MAP) target for renal protection in septic shock remains unclear. Although higher MAP targets have been suggested to improve renal outcomes in selected patient subgroups, it...
Remimazolam in pediatric sedation and anesthesia: current perspectives and clinical considerations [0.03%]
儿童镇静和麻醉中瑞米扎唑的应用：当前观点与临床考虑因素
Satoshi Kimura,Moritoki Egi
Satoshi Kimura
Remimazolam is a novel, short-acting benzodiazepine that acts as a high-affinity selective ligand for the GABA-A receptor. Since its approval, growing evidence has demonstrated its safety and efficacy for sedation and anesthesia in adult pa...
Computed tomography in ARDS, from morphological insights to AI-powered multi-modal analysis: a narrative review [0.03%]
ARDS的CT影像特征及其多模态人工智能分析：综述
Zirui Xu,Yongran Wu,Azhen Wang et al.
Zirui Xu et al.
Background: Acute respiratory distress syndrome (ARDS) is a critical clinical condition characterized by acute respiratory failure and high mortality. It poses considerable challenges in both diagnosis and management. Ima...
Jean-Pierre Quenot,Marine Jacquier,Isabelle Fournel et al.
Jean-Pierre Quenot et al.
Postintensive care syndrome (PICS) encompasses physical, psychological, and cognitive sequelae following an intensive care unit (ICU) stay, with repercussions also extending to patients' families (PICS-F). Beyond health-related outcomes, IC...
The hemodynamics of tracheal intubation in critically ill patients: a narrative review [0.03%]
危重患者气管插管的血流动力学变化：综述
Yuki Kotani,Takatoshi Koroki,Yoshiro Hayashi et al.
Yuki Kotani et al.
Background: Tracheal intubation is a ubiquitous but high-risk procedure in critically ill patients, often required in the setting of severe hypoxemia, shock, or metabolic acidosis. Despite being a life-saving procedure, i...
Critical evaluation of "Exploratory characterization of dynamic soluble programmed death-ligand 1 trajectories and their association with mortality in critical COVID-19" [0.03%]
对“关键COVID-19中动态可溶性程序性死亡配体1轨迹的探索性特征及其与死亡率的关系”的批判性评价
Zubaida Bibi,Kausar Ali
Zubaida Bibi
Recent work describing longitudinal soluble programmed death-ligand 1 (sPD-L1) trajectories in critically ill patients with COVID-19 provides valuable insight into immune checkpoint dynamics and mortality risk. However, interpretation of th...
SOFA-2 versus SOFA-1 for mortality prediction in critically ill patients [0.03%]
用于危重患者死亡预测的SOFA-2和SOFA-1的对比研究
Songjie Bai,Meiling Huang,Hui Chen et al.
Songjie Bai et al.
We validated the SOFA-2 score against the SOFA-1 score using 65,366 critically ill patients from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. SOFA-2 demonstrated superior discrimination for ICU mortality (AUROC: 0...
Short- and long-term outcomes of elderly patients with acute kidney injury to acute kidney disease [0.03%]
老年急性肾损伤至慢性肾脏病的短期及长期结局
Qinglin Li,Dong Zhang,Xiaonan Ding et al.
Qinglin Li et al.
Objective: Acute kidney disease (AKD) describes acute or subacute renal damage and/or loss of kidney function between 7 and 90 days after AKI initiation. Because there are few reports on AKD in older patients, the present...
Granulocyte and monocyte adsorption therapy in sepsis: a propensity score-matched analysis [0.03%]
粒细胞和单核细胞吸附疗法治疗脓毒症的倾向分值匹配分析
Ryo Hisamune,Kazuma Yamakawa,Tomoyuki Nakamura et al.
Ryo Hisamune et al.
Background: Granulocyte and monocyte adsorption therapy has been explored as an adjunctive treatment for sepsis due to its potential to modulate excessive systemic inflammation. However, clinical evidence characterizing i...