Nedd4L signaling contributes to carbon tetrachloride-induced liver fibrosis in female mice and is associated with enteric dysbacteriosis [0.03%]
Nedd4L信号传导有助于四氯化碳诱导的雌性小鼠肝纤维化并与肠菌群失调相关
Cheng Chen,Yanghui Bi,Bangtao Chen et al.
Cheng Chen et al.
Background: Liver fibrosis is characterized by hepatic stellate cell (HSC) activation and collagen overproduction, but its pathogenesis remains largely unknown. This study aimed to uncover the role of neural precursor cel...
Chengji Tang,Jia Zhou,Yinghui Song et al.
Chengji Tang et al.
Exocrine pancreatic insufficiency (EPI) is a major cause of maldigestion and malnutrition, resulting from primary pancreatic diseases or other conditions. As the prevalence of EPI continues to rise, accurate identification of its etiology h...
Potential function of hepatic Niemann-Pick C1-like 1: cholesterol homeostasis regulation of the canalicular lipid bilayer membrane [0.03%]
肝Niemann-Pick C1类蛋白1的潜在功能：胆管脂质双层膜的胆固醇稳态调节
Hongtan Chen,Pingfan Mo,Guoqiang Xu
Hongtan Chen
Niemann-Pick C1-like 1 (NPC1L1) is distributed in the human liver and intestine but only slightly expressed in the mouse liver. While it is well established that intestinal NPC1L1 is crucial for the absorption of exogenous cholesterol, the ...
Reassessing the role of nitric oxide in the pathogenesis of sphincter of Oddi dysfunction [0.03%]
一氧化氮在Oddi括约肌功能障碍发病机制中的作用的再评价
Haonan Lin,Yixuan Liang,Wangqiang Zhao et al.
Haonan Lin et al.
The pathogenic mechanisms underlying sphincter of Oddi dysfunction (SOD) remain incompletely understood, and it often leads to severe symptoms encompassing nausea, vomiting, and abdominal pain. New evidence now suggests correlations between...
An unusual gastric submucosal prominence diagnosed as hereditary hemorrhagic telangiectasia [0.03%]
诊断为遗传性出血性毛细血管扩张症的胃粘膜下隆起一例
Likun Zhong,Hua Lin,Jianwen Nong et al.
Likun Zhong et al.
Micro-environmental changes indicate potential for subclinical intestinal tissue damage in early-age-onset colorectal cancer patients [0.03%]
微环境的变化表明早期发病的结肠直肠癌患者可能出现亚临床肠道组织损伤
Sean G Kraus,Katherine A Johnson,Philip B Emmerich et al.
Sean G Kraus et al.
Background: While improved screening rates have contributed to an overall decrease in the incidence of colorectal cancer (CRC), the incidence of early-age-onset CRC (EAO CRC; age
Shu Sasaki,Luis Veloza,Christine Sempoux et al.
Shu Sasaki et al.
Risk-stratified hepatocellular carcinoma surveillance in non-cirrhotic patients with MASLD [0.03%]
非肝硬化MASLD患者肝细胞癌风险分层监测
Ke Mi,Tingdan Ye,Lin Zhu et al.
Ke Mi et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is rapidly emerging as the leading global liver disorder and is poised to become the primary cause of hepatocellular carcinoma (HCC). Research indicates that nearly 50% of HCC...
Coexisting steatotic liver disease is not associated with long-term liver-related events in patients with chronic hepatitis B [0.03%]
肝脂肪变与慢性乙型肝炎患者的长期肝脏相关事件无关
Navavee Uman,Apichat Kaewdech,Pimsiri Sripongpun et al.
Navavee Uman et al.
Steatotic liver disease (SLD) is an emerging liver disease, whereas chronic viral hepatitis is the renowned cause of chronic liver disease leading to cirrhosis and hepatocellular carcinoma (HCC). The impact of coexisting SLD in chronic hepa...
Odevixibat as a possible rescue therapy in a pediatric patient with vanishing bile ducts syndrome associated with ethosuximide-induced DILI-DRESS [0.03%]
奥德西巴特在乙琥胺诱导的DILI-DRESS伴进行性家族性肝内胆汁淤积症综合征患儿中作为潜在补救疗法的成功尝试
Silvio Veraldi,Luca Della Volpe,Valerio Cecinati et al.
Silvio Veraldi et al.