Dysfunction of mitochondria in intestinal epithelial cells: a key player in the pathogenesis of inflammatory bowel diseases [0.03%]
肠道上皮细胞线粒体功能障碍在炎症性肠病发病机制中的作用
Jiangmei Pang,Mingshan Jiang,Yongbin Jia et al.
Jiangmei Pang et al.
Inflammatory bowel diseases (IBD) are a group of chronic gastrointestinal disorders with increasing incidence and prevalence that represent a major challenge for healthcare systems worldwide. Owing to their intricate and largely unknown eti...
Targeting engulfment and cell motility 1 protein methylation attenuates M2 macrophage infiltration and boosts anti-PD-1 efficacy in colorectal cancer [0.03%]
靶向Engulfment and Cell Motility 1蛋白甲基化可减轻M2型巨噬细胞浸润并增强抗PD-1在结直肠癌中的疗效
Guanman Li,Zexian Chen,Kai Wang et al.
Guanman Li et al.
Background: Immunotherapy has been very successful in the field of cancer treatment. However, some patients exhibit unresponsive to PD-1 blockade, even for microsatellite instability-high (MSI-H) colorectal cancer (CRC). ...
Current advances and future directions in the management of HBV-related hepatocellular carcinoma [0.03%]
乙型肝炎相关肝细胞癌的治疗新进展与未来方向
Andrew F Ibrahim,Julie Sang,Pojsakorn Danpanichkul et al.
Andrew F Ibrahim et al.
Hepatocellular carcinoma (HCC) remains a major driver of global cancer mortality, with HCC incidence projected to rise in the coming decades and chronic hepatitis B virus (HBV) continuing to account for a substantial proportion of cases wor...
Immune-based personalized elimination diet for the treatment of irritable bowel syndrome: a double-blind randomized sham-controlled study [0.03%]
基于免疫的个性化排除饮食治疗肠易综合征：一项双盲随机假饮食对照研究
Offir Ukashi,May Tzur,Doron Yablecovitch et al.
Offir Ukashi et al.
Background: Dietary interventions and multiple food-item restrictions are challenging for patients with irritable bowel syndrome (IBS), and associated with inadequate adherence. We aimed to examine the efficacy of an indi...
GIPC2 suppresses colorectal cancer progression via regulation by UBA1-mediated ubiquitination [0.03%]
UBA1介导的泛素化调节的GIPC2通过抑制结直肠癌进展
Xinye Cui,Yuzhuo Chen,Quan Rao et al.
Xinye Cui et al.
Background: Colorectal cancer (CRC) constitutes a major worldwide cancer challenge, characterized by consistently increasing numbers of new cases and deaths. GIPC2, a molecule with context-dependent regulatory functions a...
Impact of incisura biopsy on the surveillance of precursor lesions and gastric cancer risk assessment [0.03%]
胃窦活检对前驱病变监测和胃癌风险评估的影响
Elisa Cantú-Germano,Sonia Torres,Glòria Fernández-Esparrach et al.
Elisa Cantú-Germano et al.
Background: The diagnostic value of an incisura biopsy during upper gastrointestinal endoscopies (UGEs) for detecting gastric cancer precursor lesions (GCPLs) remains debated. This study aimed to evaluate the impact of in...
Endoscopic ultrasound versus direct transjugular portal pressure gradient in patients receiving TIPS: influence of portal vein thrombosis [0.03%]
内镜超声与直接颈静脉测量门脉压差在经颈静脉肝内门体分流术患者中的对比研究：门静脉血栓病的影响
Irina Dragomir,Cristina Pojoga,Claudia Hagiu et al.
Irina Dragomir et al.
Background: Endoscopic ultrasound (EUS) has emerged as a valuable tool for assessing portal hypertension (PH). Our study aimed to compare endoscopic ultrasound-guided portal pressure gradient (EUS-PPG) with directly measu...
Learning curve for endoscopic retrograde appendicitis therapy: a multicenter retrospective study with different levels of trainees [0.03%]
内镜下阑尾炎治疗的学习曲线：不同培训阶段的多中心回顾性研究
Jiyu Zhang,Jianping Fan,Haipeng Yuan et al.
Jiyu Zhang et al.
Background and aim: Endoscopic retrograde appendicitis therapy (ERAT) is a minimally invasive treatment for appendicitis, widely practiced in China. Clarifying the learning curve, especially among endoscopists with varyin...
Histopathologic characterization and clinical associations of ileal pouch polyps in inflammatory bowel disease [0.03%]
炎症性肠病患者回肠储袋息肉的病理特征及临床相关因素分析
Yin Guo,Shanshan Wang,Won-Tak Choi et al.
Yin Guo et al.
Background: Polyps are frequently found in patients with chronic inflammatory disorders of the pouch. While neoplastic transformation is the major concern, most pouch polyps are non-dysplastic. Benign polyps may lead to a...
DGCNet: a clinical knowledge-driven model for the segmentation of reflux esophagitis in endoscopic images [0.03%]
基于临床知识驱动的内镜图像反流性食管炎分割模型
Zhenyang Ge,Youjiang Fang,Jiuyang Chang et al.
Zhenyang Ge et al.
Background: Digestive endoscopy is vital for diagnosing reflux esophagitis (RE) and is crucial for assessing disease severity. Although some existing pixel-level precision segmentation models can achieve fine-grained lesi...