The ATXN2 9 bp duplication in SCA3: clarifying evidence and correcting misinterpretations [0.03%]
SCA3中ATXN2的9 bp重复：阐明证据并纠正误释
Jose Miguel Laffita-Mesa,Martin Paucar,Per Svenningsson
Jose Miguel Laffita-Mesa
Lauerer et al. (Acta Neuropathol Commun 13:157, 2025) recently investigated the role of ATXN2 variants, including intermediate CAG repeats and a 9-bp duplication, in spinocerebellar ataxia type 3 (SCA3). While their study contributes valuab...
High-plex spatial protein profiling of skeletal muscle biopsies in inflammatory myopathies using the MACSima™ imaging platform: A pilot study [0.03%]
使用MACSima™成像平台对炎性肌病活检标本进行高通量空间蛋白组分析：一项初步研究
Monica Sciacco,Daniele Velardo,Letizia Bertolasi et al.
Monica Sciacco et al.
Inflammatory myopathies represent a heterogeneous group of autoimmune disorders affecting skeletal muscle, with distinct pathological features. While muscle biopsy remains a key diagnostic tool, conventional immunohistochemical approaches a...
Spatial omics in high-grade glioma: study design, analytical pitfalls, and standards for reproducible neuro-oncology [0.03%]
高级别胶质瘤的空间组学：研究设计、分析陷阱和可重复神经肿瘤学标准
Ismail A Abdullah,Itika Arora,Saniyah Shaikh et al.
Ismail A Abdullah et al.
Laura Gomez-Isaza,Olga Pletnikova,Maria Luongo et al.
Laura Gomez-Isaza et al.
Usefulness OF SOX10 immunohistochemistry for subtyping diffuse midline gliomas EGFR-altered [0.03%]
SOX10免疫组织化学在EGFR改变的弥漫性中线胶质瘤分类中的应用价值评估
Arnault Tauziède-Espariat,David Castel,Yassine Ajlil et al.
Arnault Tauziède-Espariat et al.
GFAP degradation in TBI: linking novel modified products to astrocyte pathology and patient outcome [0.03%]
TBI中GFAP降解：将新型修饰产物与星形胶质细胞病理和患者结局联系起来
Ina-Beate Wanner,Julia Halford,Jonathan Lopez et al.
Ina-Beate Wanner et al.
Glial fibrillary acidic protein (GFAP) is a significant clinical biomarker of traumatic brain injury (TBI), yet understanding the nature, timing, and impact of its degraded and modified products would inform clinical utility. We report nove...
The octapeptide repeats of prion protein play critical roles in the pathogenesis of prion diseases [0.03%]
八肽重复序列在朊毒病发病机制中起关键作用
Xiangyi Zhang,Jingjing Zhang,Yan Zhang et al.
Xiangyi Zhang et al.
Complement deposition, IgG subtyping and endplate destruction in LRP4-ab-positive myasthenia gravis [0.03%]
LRP4自身免疫阳性重症肌无力中补体沉积、IgG亚型及终板破坏的研究
Sarah Hoffmann,Katharina Brokamp,Andreas Meisel et al.
Sarah Hoffmann et al.
Involvement of the complement system in myasthenia gravis (MG) depends on the IgG subclass of the mediating antibody. LRP4 antibodies (LRP4-ab) are typically of the IgG1 or IgG2 subclass, implying distinct capacities to activate complement....
Tumor-like proliferation of CCM3 knockout endothelial cells: insights from semaxinib treatment and transcriptome profiling of co-cultures [0.03%]
CCM3基因敲除内皮细胞肿瘤样增生：来自Semaxinib治疗和共培养转录组分析的见解
Valeriia V Saenko,Janne L Feldmann,Dariush Skowronek et al.
Valeriia V Saenko et al.
Cerebral cavernous malformations (CCMs) are vascular lesions associated with severe neurological complications. Increasing evidence suggests that cancer-like mechanisms, like an abnormal expansion of CCM3 knockout (KO) endothelial cells (EC...
The adhesion GPCR ADGRV1 controls glutamate homeostasis in hippocampal astrocytes supporting neurons [0.03%]
黏附G蛋白偶联受体ADGRV1控制海马星形胶质细胞中的谷氨酸稳态以支持神经元
Baran E Güler,Mark Zorin,Joshua Linnert et al.
Baran E Güler et al.
ADGRV1 is the largest member of adhesion G protein-coupled receptor (aGPCR) family. In the cell, aGPCRs serve in two major functions, namely in cell adhesion and signal transduction. Mutations in ADGRV1 were linked not only to Usher syndrom...