Ablation of progranulin augments microglial activation and accelerates prion progression [0.03%]
程序性移除progranulin可增强小胶质细胞活化并加速小胶蛋白进展
Bei Li,Yiyue Shi,Wenyu Hou et al.
Bei Li et al.
Mutations or polymorphisms in GRN, encoding the CNS glycoprotein progranulin (PGRN), have been linked to several neurodegenerative diseases. In this study, we explored the role of PGRN in prion diseases. We observed that prion infection upr...
White adipose tissue undergoes pathological dysfunction in the TDP-43A315T mouse model of amyotrophic lateral sclerosis (ALS) [0.03%]
TDP-43A315T小鼠模型中的肌萎缩侧索硬化(ALS)患者白色脂肪组织出现病理功能障碍
Cristina Benito-Casado,Esther Durán-Mateos,Águeda Ferrer-Donato et al.
Cristina Benito-Casado et al.
White adipose tissue (WAT) has a crucial role in maintaining systemic energy homeostasis. Numerous biological pathway studies have highlighted the importance of adipokines in regulating metabolic pathways and contributing to metabolic dysfu...
New experimental therapies for glioblastoma: a review of preclinical research [0.03%]
胶质母细胞瘤新实验疗法的前期临床研究述评
Arseniy E Yuzhalin
Arseniy E Yuzhalin
Glioblastoma is the most common and malignant glial tumor of the central nervous system with an incidence from 0.59 to 3.69 per 100 000 depending on the region. Patient prognosis remains poor, highlighting the urgent need for novel therapie...
Deep learning based semi-automated model can predict lineage in patients with pituitary neuroendocrine tumors [0.03%]
基于深度学习的半自动化模型可以预测垂体神经内分泌肿瘤患者的谱系
Guoqing Wu,Zehang Ning,Xiaorong Yan et al.
Guoqing Wu et al.
Pituitary neuroendocrine tumors (PitNETs) represent the most prevalent category of neuroendocrine neoplasms. Contemporary classification paradigms emphasize transcription factor immunohistochemistry (IHC) as a cornerstone for molecular subt...
Two molecular subtypes of skull base meningiomas with extracranial extension [0.03%]
具颅外扩展倾向的颅底脑膜瘤分子亚型研究
Yudai Hirano,Motoyuki Umekawa,Satoru Miyawaki et al.
Yudai Hirano et al.
Dendritic beading during early brain development impairs signal transmission and synaptic plasticity [0.03%]
发育初期树突肿胀影响信号传导及突触可塑性
Pratyush Suryavanshi,Satya Murthy Tadinada,Samuel Baule et al.
Pratyush Suryavanshi et al.
Excessive glutamate receptor activation during brain pathologies causes varicose dendritic swelling, also known as "dendritic beading", yet its impact on developing brain circuits is poorly understood. Using field electrophysiology and two-...
The mGluR5 agonist CHPG enhances human oligodendrocyte differentiation [0.03%]
mGluR5激动剂CHPG能增强人类少突胶质细胞的分化
Yangyang Huang,Celine Geywitz,Anjalika Bandaru et al.
Yangyang Huang et al.
Previous studies in adult mice indicate that the mGluR5 agonist 2-chloro-5-hydroxyphenyl glycine (CHPG), reduces cuprizone-elicited losses in myelin. This effect is partly mediated by CHPG binding to mGluR5 receptors on reactive astrocytes,...
Clinical and inflammatory factors associated with the extent of resection in primary, sporadic vestibular schwannomas: A retrospective study [0.03%]
与前庭神经鞘瘤原发肿瘤体积相关的临床及炎症因素的回顾性研究
Lorenz Dörner,Elisa-Maria Suhm,Vanessa Ries et al.
Lorenz Dörner et al.
Background: The extent of resection (EOR) is known to impact recurrence free survival in vestibular schwannomas (VS). Identifying predictive factors for complete resection may direct treatment decisions in the future. In ...
Cryo-EM studies of amyloid-β fibrils from human and murine brains carrying the Uppsala APP mutation (Δ690-695) [0.03%]
携带乌普萨拉APP突变(Δ690-695)的人类和小鼠脑中淀粉样蛋白-β原纤维的冷冻电镜研究
Mara Zielinski,Fernanda S Peralta Reyes,Lothar Gremer et al.
Mara Zielinski et al.
Today, 13 intra-amyloid-β (Aβ) amyloid precursor protein (APP) gene mutations are known to cause familial Alzheimer's disease (AD). Most of them are point mutations causing an increased production or a change in the conformation of Aβ. T...
Diffuse leptomeningeal glioneuronal tumour: molecular diagnosis, evolution and treatment [0.03%]
弥漫性脑膜神经胶质瘤的分子诊断、演变及治疗
Anastasia Campanelli,Alice Métais,Yassine Bouchoucha et al.
Anastasia Campanelli et al.