Time-dependent prognostic value of automated Ki67 assessment and its integration with molecular risk profiling in WHO grade 2 meningioma [0.03%]
基于WHO II级脑膜瘤的Ki67自动化评估及其与分子风险分层整合的时间依赖性预后价值研究
Luisa Voßbeck,Felix Ehret,Eilis Perez et al.
Luisa Voßbeck et al.
WHO grade 2 meningiomas exhibit highly heterogeneous clinical courses. While the Ki67 proliferation index is a standard biomarker, its prognostic utility remains limited by methodological inconsistency and potential time-dependent dynamics....
Methylation profiling and alternative classification approaches in a glioma-enriched FFPE stereotaxic biopsy cohort [0.03%]
甲基化谱分析和替代分类方法在胶质瘤富集的立体定位活检福尔马林固定石蜡包埋队列中的应用
Katharina Johanna Weber,Jürgen Hench,Markus Zumpt et al.
Katharina Johanna Weber et al.
DNA methylation profiling of CNS tumors supports and refines histological diagnoses. Tumor DNA methylation signatures allow for an alignment with reference methylation classes and copy number profiling required for molecular grading. Overal...
Gene supplementation therapy restores motor deficits in Gnao1[C215Y] mice and proves broad efficacy in C. elegans model [0.03%]
基因补充疗法可恢复Gnao1[C215Y]小鼠的运动障碍，并在秀丽隐杆线虫模型中证明了其广泛的有效性
Germana Cocozza,Tiziano D&#x;Andrea,Martina Di Rocco et al.
Germana Cocozza et al.
The heterotrimeric G proteins are ubiquitous membrane-bound complexes specialized in the transduction of receptor-mediated extracellular signals into intracellular responses. Mutations in the G protein subunit alpha O1 (Gαo), encoded by GN...
Correction: A rare missense variant impacting NEK1 kinase function is associated with ALS [0.03%]
订正：NEK1激酶功能影响变异体与ALS相关联
David Brenner,Anna Ponomarenko,Iris Petrut et al.
David Brenner et al.
Published Erratum
Acta neuropathologica communications. 2026 Jul 20;14(1):153. DOI:10.1186/s40478-026-02380-1 2026
Multi-omics characterization of IDH-mutant astrocytoma-derived cell lines reveals NOTCH-regulated plastic quiescent astrocyte-like state and insights into progression [0.03%]
IDH突变型星形细胞瘤衍生细胞系的多组学表征揭示NOTCH调节的具有可塑性的静息态星形样状态及对疾病进展的新见解
Leonor Garcia,Christine Granotier-Beckers,Donovan Pineau et al.
Leonor Garcia et al.
Diffuse IDH-mutant astrocytomas are brain tumors typically diagnosed as low-grade but capable of progressing to higher grades. They exhibit three cellular states resembling astrocytes, oligodendrocytes, and neural progenitor (NPC) cells. Un...
Amygdalar nuclei vulnerability to protein aggregates in Lewy body diseases [0.03%]
路易体疾病中杏仁复合核对蛋白聚集物的易感性
Natasja A C Deshayes,Janna van Wetering,Alex Wesseling et al.
Natasja A C Deshayes et al.
The amygdala is highly vulnerable to protein aggregation and heavily affected in Lewy body diseases (LBDs). However, vulnerability might vary per amygdalar nucleus and it is unclear if the pattern of vulnerability across the nuclei differs ...
Multimodal molecular mapping of the vasculature in human cortex reveals lipid markers of cerebral amyloid angiopathy [0.03%]
人脑皮层多模态分子血管图谱揭示了脑淀粉样血管病的脂质标志物
Cody R Marshall,Felipe A Moser,Claire F Scott et al.
Cody R Marshall et al.
Cerebral amyloid angiopathy (CAA) commonly co-occurs with Alzheimer's disease (AD), yet the molecular changes that accompany vascular [Formula: see text]-amyloid deposition in human tissue remain incompletely defined. Herein, we use a novel...
Correction: NSC-derived extracellular vesicles-mediates neuronal plasticity enhancement in vascular dementia via transferring miR-210 [0.03%]
订正：NSC源外泌体通过转移miR-210介导血管性痴呆相关神经可塑性增强
Qunwen Pan,Yan Wang,Zhi Xiang et al.
Qunwen Pan et al.
Published Erratum
Acta neuropathologica communications. 2026 Jul 18;14(1):151. DOI:10.1186/s40478-026-02358-z 2026
Platelet transcriptomic signatures in pediatric brain tumors distinguish cancer from cancer-free control [0.03%]
儿童脑肿瘤中的血小板转录组特征可区分癌症与健康对照
Markus Talka,Amanda Holmström,Jonathan Hiekka et al.
Markus Talka et al.
Malignant pediatric brain tumors remain the leading cause of cancer-related mortality in children. Current diagnostics and monitoring rely on imaging and invasive biopsy, which may not capture tumor heterogeneity. Liquid biopsy-based biomar...
Successful bioassay of blood from chronic wasting disease-affected cervids in cervid PrP transgenic Drosophila [0.03%]
慢性消耗性疾病受感染鹿血的高效生物检测实验在鹿PrP转基因果蝇中开展成功
Alana M Thackray,Erin E McNulty,Amy V Nalls et al.
Alana M Thackray et al.
Chronic wasting disease is a fatal transmissible prion condition of free-ranging and farmed cervids including deer, elk, moose, muntjac and reindeer. Prionemia is a pathogenic feature of chronic wasting disease in cervids and underpins deve...