CD155 and its receptors in glioma: prospects for emerging immune checkpoint inhibitors [0.03%]
胶质瘤中的CD155及其受体：新兴免疫检查点抑制剂的前景
Mingyao Huang,Youchen Cui,Xiaoqian Wang et al.
Mingyao Huang et al.
Glioma is an aggressive brain malignancy characterized by a markedly immunosuppressive microenvironment and limited response to conventional treatments. CD155, also known as the poliovirus receptor, is frequently overexpressed in glioma and...
Characterization of a distinct form of vimentin in the neurodegenerative brain [0.03%]
神经退行性大脑中vimentin的一种特殊形式的特征描述
Abdulkhalek Dakhel,Johanna Vestin,Vilmantas Giedraitis et al.
Abdulkhalek Dakhel et al.
Alzheimer's disease (AD) and Parkinson's disease (PD) are characterized by brain accumulation of aggregated proteins, leading to neuronal and glial dysfunction. Compelling data indicate that changes in vimentin expression, structure, and lo...
Dysregulated oligodendrocyte and myelin dynamics as an early pathological feature of neuropil degeneration in Alzheimer's disease: an ultrastructural study [0.03%]
阿尔茨海默病神经纤维丛变性早期的少突胶质细胞和髓鞘异常：一项超微结构研究
Alev Erisir,Erin E Maher,Zoe Anderson et al.
Alev Erisir et al.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder traditionally defined by the accumulation of amyloid‑β plaques and neurofibrillary tangles. Increasing evidence suggests that white‑matter degeneration and myelin disru...
Dissecting acute neuronal responses to glioblastoma using a dual-interface human iPSC neuronal culture platform [0.03%]
利用双界面人多能干细胞神经元培养平台剖析胶质母细胞瘤的急性神经反应
Ouada Nebie,Niyi Adelakun,Brian Fries et al.
Ouada Nebie et al.
Glioblastoma (GB) hijacks neuronal circuits to promote tumor progression, but the earliest neuronal responses remain poorly defined. We developed a dual-interface human iPSC-derived neuronal model to study acute paracrine signaling triggere...
Investigation of the myelin-amyloid interplay in Alzheimer's disease: insights from novel dsCMA imaging in mouse and human brains [0.03%]
阿尔茨海默病髓鞘与淀粉样蛋白相互作用的探讨：来自小鼠和人类大脑新型dsCMA成像的新见解
Hanpeng Xu,Sumit Nanda,Jiandong Sun et al.
Hanpeng Xu et al.
Myelin deterioration impairs neural communication and may contribute to neurodegenerative diseases such as Alzheimer's disease (AD). However, the spatiotemporal relationship between myelin degeneration and AD pathology remains unclear. We d...
Multimodal profiling of immune responses reveals innate-adaptive immune imbalance in human bornavirus encephalitis [0.03%]
免疫多模态谱型揭示了人 Bornaviruses 脑炎中的固有-适应性免疫失衡
Nicola Jungbäck,Przemyslaw Grochowski,Daniel Hieber et al.
Nicola Jungbäck et al.
Human bornavirus encephalitis (BVE) is a rare, emerging and fatal zoonotic disease mainly caused by the Borna disease virus 1 (BoDV-1), a non-cytolytic RNA virus. Despite increasing recognition, the immunopathogenesis of human BoDV-1 infect...
Glioblastoma cells utilize evolutionarily adapted cell metabolism to promote their malignant proliferation [0.03%]
胶质母细胞瘤细胞利用进化适应的细胞代谢来促进其恶性增殖
Maxim M Bespalov,Vasiliki Gkini,Zeynep Iloglu et al.
Maxim M Bespalov et al.
Glioblastoma is the most aggressive primary brain tumor in adults, with limited therapeutic success and, therefore, poor prognosis. Its malignancy is partly driven by the high proliferative capacity of glioblastoma cells, yet the underlying...
Age-dependent peripheral dissemination of α-synuclein seeds: mechanistic basis for blood-based early detection of Parkinson's disease [0.03%]
基于年龄的外周α-突触核蛋白种子扩散：血液早期检测帕金森病的机制基础
Yaoyun Kuang,Hengxu Mao,Hao Lin et al.
Yaoyun Kuang et al.
Early diagnosis of Parkinson's disease (PD) before extensive neurodegeneration is a critical unmet need, largely due to the absence of sensitive, minimally or non-invasive biomarkers for the prodromal stage. Here, we primarily use α-synucl...
Knockout of Rab27b exacerbates neuropathology in alpha-synuclein mouse models [0.03%]
Rab27b基因敲除可加重α-突触核蛋白小鼠模型的神经病理变化
Kasandra Scholz,Mary A Gannon,Lehmann Matheny et al.
Kasandra Scholz et al.
Parkinson's Disease (PD) and other synucleinopathies are characterized by the formation of inclusions comprised of alpha-synuclein (αsyn) among other proteins, but the mechanisms by which these inclusions form and cause toxicity are not we...
Decreased PP2A expression and activity represent a therapeutic target for plexiform neurofibroma [0.03%]
PP2A表达降低和活性下降是plexiform神经纤维瘤的治疗靶点
Minghui Yue,Yixiao Wang,Jiabao Gu et al.
Minghui Yue et al.
In neurofibromatosis type 1 (NF1), loss-of-function mutations in the NF1 gene increase activation of the RAS-MEK-ERK signaling cascade, driving tumorigenesis. MEK inhibitors (MEKi) inhibit tumor growth and significantly shrink nerve tumors ...