Enhancing heme synthesis attenuates pathological α-synuclein propagation in vivo [0.03%]
血红素合成增强剂通过体内病理α-突触核蛋白传播
Masami Masuda-Suzukake,Masato Hasegawa,Takashi Nonaka
Masami Masuda-Suzukake
Intraneuronal α-synuclein (αS) accumulation is a central event in the pathogenesis of Parkinson's disease and dementia with Lewy bodies. The spread of αS pathology throughout the central nervous system contributes to disease progression ...
Age-dependent vascular and neurological characteristics of CADASIL are recapitulated in Notch3 mutant zebrafish, implicating a role for type IV collagen in disease progression [0.03%]
NOTCH3突变斑马鱼模拟CADASIL的年龄依赖性血管和神经病理特征，提示IV型胶原蛋白在疾病进展中的作用
Tohgo Kanoh,Shiho Oubayashi,Kengo Furukawa et al.
Tohgo Kanoh et al.
CADASIL is a hereditary cerebral small vessel disease caused by NOTCH3 mutations, leading to age-dependent vascular and neurological impairments. Despite its clinical impact, the underlying pathogenic mechanisms remain poorly understood, pa...
Temporal dynamics of neuroplasticity and neurodegeneration in the central auditory system following noise-induced hearing loss: a multimodal imaging and histological study [0.03%]
噪声引起的听力损失后中枢听觉系统神经可塑性和神经退行性变的动态变化：多模式成像和组织学研究
Víctor Giménez-Esbrí,Susanne Schwitzer,Susanne Mueller et al.
Víctor Giménez-Esbrí et al.
Noise-induced hearing loss (NIHL) is a sensorineural disorder that provokes complex neuroplastic and neurodegenerative changes within the central nervous system (CNS). This study investigated the temporal dynamics of neuronal density, axona...
Polymeric lysosome-targeting chimeras for extracellular α-synuclein degradation in Parkinson's disease [0.03%]
用于帕金森病细胞外α-突触核蛋白降解的聚合物溶酶体靶向嵌合体
Arghya Bhattacharya,Hailah M Almohaimeed,Waheeb Sami Aggad et al.
Arghya Bhattacharya et al.
Disease progression in Parkinson's disease has been driven by extracellular α-synuclein prion-like seeding throughout the course of the disease and therefore not just by the intracellular accumulation of the protein in isolated aggregates....
Correction: From origins to nomenclature: illuminating the landscape of CNS fibroblasts and fibroblast-like cells [0.03%]
关于中枢神经系统成纤维细胞及成纤维细胞样细胞的更正：从起源到命名体系明晰中枢神经系统的景观格局
Jianing Lin,Kuo Liao,Sebastian A Lewandowski
Jianing Lin
Published Erratum
Acta neuropathologica communications. 2026 Jun 1;14(1):118. DOI:10.1186/s40478-026-02338-3 2026
Distinctive hydrocephalus-like phenotype in NOTCH2NLC-related neuronal intranuclear inclusion disease: clinicopathological features and therapeutic implications [0.03%]
NOTCH2NLC相关的神经细胞内包涵体疾病特有的脑积水样表型：临床病理特征及治疗意义
Shaoping Zhong,Yangye Lian,Binbin Zhou et al.
Shaoping Zhong et al.
NOTCH2NLC-related neuronal intranuclear inclusion disease (NIID) is a progressive neurodegenerative disorder with marked clinical heterogeneity and an increasingly recognized phenotypic spectrum. Although hydrocephalus-like presentations, i...
ATM-kinase deficiency triggers early multi-compartment remodeling of the cerebellar microenvironment [0.03%]
ATM激酶缺乏触发小脑微环境多个隔室的早期重构现象
Francesca Montarolo,Luna Berrino,Anita Maria Rominto et al.
Francesca Montarolo et al.
Ataxia Telangiectasia (A-T) is a neurodegenerative disorder characterized by early onset, cerebellar ataxia and progressive motor decline. The causative gene, ATM (A-T Mutated), encodes a Ser/Thr kinase, that belongs to the phosphoinositide...
VAPB confers selective neuroprotection by driving autophagic degradation of pathogenic aggregates in ALS [0.03%]
VAPB通过驱动自噬降解ALS病理性聚集物从而实现选择性神经保护作用
Priyanka Tripathi,Haihong Guo,Alfred Yamoah et al.
Priyanka Tripathi et al.
During the progression of amyotrophic lateral sclerosis (ALS), only specific motor neurons (MNs) preferentially deteriorate, while others are spared until the disease reaches its end stage. Resilient MNs possess several protective factors, ...
Comprehensive characterization of spinal ependymomas in NF2-Schwannomatosis [0.03%]
NF2- Schwannomatosis脊髓室管膜瘤的全面表征
Pauline Marijon,Yu Teranishi,Franck Bielle et al.
Pauline Marijon et al.
Background: Spinal ependymomas (SE) account for 10% of ependymomas and are the most frequent spinal glial tumors. NF2-related Schwannomatosis (NF2-SWN) patients are predisposed to multiple SE in addition to other tumors, ...
Pituitary blastoma in a dog: comparative clinical, imaging, and pathologic features of a newly recognized and rare human entity [0.03%]
犬垂体巨细胞瘤的临床、影像及病理特征与一种罕见的人类肿瘤的比较研究
Giuseppe Giglia,Cristian Falzone,Mariagiovanna Lorena Graceffa et al.
Giuseppe Giglia et al.
Pituitary blastoma (PitB) is an exceedingly rare tumor originating from the anterior pituitary gland, first documented in 2008 in humans. It is considered pathognomonic for DICER1 syndrome, primarily affecting children, although cases in ad...