Patient-derived glioblastoma cultures preserve respiration phenotypes during ex vivo maintenance and show sex-associated differences in migration [0.03%]
患者衍生的胶质母细胞瘤培养物在体外维持期间保留呼吸表型，并显示出性别相关的迁移差异
Veronika Matschke,Philip Glover,Robert Lucaciu et al.
Veronika Matschke et al.
Glioblastoma (GBM) is a highly heterogeneous, invasive brain tumor with profound metabolic plasticity. Patient-derived cultures provide valuable preclinical models, yet the stability and clinical relevance of their metabolic phenotypes duri...
Marine Massy,Stefanie Marti,Adriane Kutllovci et al.
Marine Massy et al.
Background: Disease reactivation following cessation of sphingosine 1-phosphate receptor modulators (S1PRM) occurs in ~ 10% of multiple sclerosis (MS) patients. The biological factors underlying this phenomenon remain inc...
Methamphetamine hijacks chaperone-mediated autophagy to degrade GPX4, driving ferroptosis-precipitated cognitive decline and addictive pathogenesis [0.03%]
甲基苯丙胺通过劫持伴侣介导的自噬降解GPX4驱动铁死亡诱发的认知功能障碍和成瘾恶化病理发展
Zizhen Si,Dan Zhu,Jianan Lv et al.
Zizhen Si et al.
Methamphetamine (METH) addiction is associated with progressive cognitive decline and maladaptive behaviors, but the molecular mechanisms bridging proteostatic dysfunction to neural circuit degeneration remain poorly defined. We hypothesize...
Cystic glioblastoma is associated with alterations of KDR and the Rb pathway: a single-center retrospective analysis [0.03%]
囊性胶质母细胞瘤与KDR和Rb通路改变有关：单中心回顾性分析
Johannes Werner,Sahar Alizada,Cheuk Hong Leung et al.
Johannes Werner et al.
Glioblastoma (GBM) is the most common malignant primary brain tumor in adults. Cystic GBM is a phenotypic subset requiring distinct clinical management. This study aimed to comprehensively assess the genomic landscape of cystic GBM. GBM, ID...
Spinal low-grade ependymal tumors harboring telomerase reverse transcriptase promoter mutation and chromosome 7 gain with methylation profile of spinal subependymoma [0.03%]
带有端粒酶倒转录酶启动子突变和染色体7增益的脊髓低级别室管膜肿瘤具有脊髓亚室管膜瘤甲基化特征
Yoshitaka Nagashima,Junya Yamaguchi,Yusuke Nishimura et al.
Yoshitaka Nagashima et al.
Spinal intramedullary tumors comprise a heterogeneous group of entities with diverse histopathological features, making their diagnosis particularly challenging. With the introduction of DNA methylation profiling, the underlying biological ...
α-Synuclein overexpression increases the tropism of pre-formed fibrils and MSA-patient derived seeds towards oligodendroglia [0.03%]
α-突触核蛋白过度表达增加预制纤维和多系统萎缩患者的种子向少突胶质细胞的趋向性
Anne-Line Strange Laursen,Frida Lind-Holm Mogensen,Jonas Folke et al.
Anne-Line Strange Laursen et al.
Multiple system atrophy (MSA) is a rare, fatal neurodegenerative disease, pathologically characterized by glial cytoplasmic inclusions (GCIs) containing α-synuclein (αSyn). The causes leading to aberrant αSyn accumulation in oligodendrog...
Correction: MRC1 and LYVE1 expressing macrophages in vascular beds of GNAQ p.R183Q driven capillary malformations in Sturge Weber syndrome [0.03%]
关于Sturge-Weber综合征中GNAQ p.R183Q驱动的毛细血管畸形血管床中的MRC1和LYVE1表达巨噬细胞的更正通知
Sana Nasim,Colette Bichsel,Stephen Dayneka et al.
Sana Nasim et al.
Published Erratum
Acta neuropathologica communications. 2026 Jun 12;14(1):130. DOI:10.1186/s40478-026-02326-7 2026
Low-intensity transcranial ultrasound stimulation suppresses abnormal neural oscillations in the motor cortex by stimulating STN in α-synucleinA53T mice [0.03%]
低强度经颅超声刺激通过刺激α-突触核蛋白A53T小鼠的STN抑制运动皮层异常神经振荡
Qianqian Wang,Shuxun Dong,Zhe Zhao et al.
Qianqian Wang et al.
Previous studies have shown that low-intensity transcranial ultrasound stimulation (TUS) of the subthalamic nucleus (STN) in mice with Parkinson's disease (PD) effectively suppresses pathological discharge activities in motor cortex. Howeve...
Soluble α-synuclein oligomers drive transient corticostriatal pathology and delayed nigral vulnerability in a mouse model of early α-synucleinopathy [0.03%]
可溶性α-突触核蛋白寡聚体驱动小鼠早期α-突触核蛋白病模型中的暂时性皮质纹状体病理和迟发型黑质易损性
Anna Wilkaniec,Grzegorz A Czapski,Magdalena Cieślik et al.
Anna Wilkaniec et al.
α-Synucleinopathies display pronounced heterogeneity in the spatial distribution of α-synuclein (αSyn) pathology and clinical progression. Although distinct αSyn assemblies-from monomers and soluble oligomers to fibrils-exert non-equiva...
Dysregulation of complement at the synapse in P301S mice and human tauopathies [0.03%]
P301S小鼠和人类tau病患者突触处补体调节紊乱
Jacqui Nimmo,Nikoleta Daskoulidou,Sophie Van Pottelberge et al.
Jacqui Nimmo et al.
Synapse loss is the best correlate of cognitive decline in neurodegenerative diseases (NDDs). In Alzheimer's disease complement dysregulation, triggered by amyloid-β accumulation, plays a major role in synapse loss, but its contribution in...