Ceramide-rich extracellular vesicles as pathogenic biomarkers in traumatic brain injury [0.03%]
富含丝氨醇的细胞外囊泡在创伤性脑损伤中的病理性生物标志物作用
Zainuddin Quadri,Zhihui Zhu,Xiaojia Ren et al.
Zainuddin Quadri et al.
Extracellular vesicles (EVs) contribute to the damage caused by traumatic brain injury (TBI) and can cross the blood-brain barrier (BBB). We analyzed plasma-derived EVs from human TBI patients to identify factors potentially contributing to...
Dynamic integration of skeletal muscle signals via extracellular vesicles in motor neuron diseases [0.03%]
运动神经元病中通过细胞外囊泡动态整合骨骼肌信号
Flaminia Riggio,Gianmarco Fenili,Daniela Caporossi et al.
Flaminia Riggio et al.
Extracellular vesicles (EVs) are heterogenous lipid bilayer-enclosed particles secreted by virtually all cell types. They encapsulate a diverse array of bioactive molecules, including proteins, lipids, nucleic acids, and metabolites, which ...
Low-input CSF cfDNA shallow whole-genome sequencing for CNV-based diagnosis and monitoring of leptomeningeal metastasis in lung cancer [0.03%]
基于CNV的肺癌脑膜转移诊断和监测的低输入CSF cfDNA全基因组浅层测序
Xiudong Guan,Yubing Li,Zongkun Shi et al.
Xiudong Guan et al.
Leptomeningeal metastasis (LM) is a life-threatening complication of lung cancer for which magnetic resonance imaging (MRI) and cerebrospinal fluid (CSF) cytology may miss disease and provide limited molecular guidance. Because the low cfDN...
Accumulation of membrane repair-associated proteins and mature myostatin are novel markers of muscle pathophysiology in Pompe disease [0.03%]
与庞培病肌病理生理相关的新型膜修复相关蛋白的积累和成熟型肌肉生长抑制素标志物的研究
Candice Babarit,Sabrina Jagot,Cindy Schleder et al.
Candice Babarit et al.
Pompe disease is an autosomal recessive metabolic disorder caused by acid alpha-glucosidase deficiency, characterized by progressive skeletal muscle weakness and respiratory insufficiency. Affected muscles exhibit glycogen-filled lysosomes,...
Localized amyloid-β oligomers in the lateral entorhinal cortex drives olfactory dysfunction through aberrant neuronal and network activity [0.03%]
侧嗅皮质淀粉样蛋白寡聚体引起的异常神经元和网络活动导致嗅觉障碍
Ting Pan,Jiaxing Fang,Xiao Wang et al.
Ting Pan et al.
Olfactory dysfunction is one of the most common early features of Alzheimer's disease (AD), yet its underlying neural mechanisms remains unclear. The lateral entorhinal cortex (LEC), a central node in the olfactory network, is among the ear...
ZFTA::YAP1-rearranged ependymoma: is still ZFTA or already YAP? [0.03%]
ZFTA::YAP1重排性室管膜瘤：是ZFTA还是已经成为YAP？
Margarita Zaytseva,Agnesa Panferova,Alexandra Tarakanova et al.
Margarita Zaytseva et al.
Under the auspices of the World Health Organization Classification of CNS Tumors (5th Edition), supratentorial ependymomas are divided into 2 main molecular groups, comprising tumors that are either ZFTA- or YAP1-fused with the majority har...
PCK2 as a potential therapeutic target for aggressive MYC-amplified non-WNT/non-SHH medulloblastoma based on tumor continuum [0.03%]
基于肿瘤连续体的PCK2作为治疗侵袭性MYC扩增型非WNT/非Sonic Hedgehog髓母细胞瘤的潜在治疗靶点
Shuaishuai Xue,Zhengming Zhan,Yonghua Cai et al.
Shuaishuai Xue et al.
Medulloblastoma, the most common malignant pediatric posterior fossa tumor, exhibits metabolic reprogramming and tumor immune microenvironment heterogeneity in non-WNT/non-SHH subgroups, yet the interplay between these features remains poor...
A stage-resolved neuron-glia transcriptional atlas reveals a glial inflammatory pivot in epilepsy [0.03%]
时空解析的神经胶质转录组图谱揭示癫痫中的胶质炎症中心地位
Toni Christoph Berger,Magnus Dehli Vigeland,Hanne Sagsveen Hjorthaug et al.
Toni Christoph Berger et al.
Background: Epileptogenesis transforms a healthy brain into an epileptic network, yet the temporal and cell-type-specific molecular events driving this transition remain poorly defined. Neuron-glia interactions are essent...
Clarification of the published survival analysis in H3F3B p.K27I-mutant diffuse midline glioma [0.03%]
H3F3B p.K27I突变弥漫性中线胶质瘤发表的生存分析澄清公告
Ryo Kurokawa,Hirokazu Takami,Yoichi Yasunaga et al.
Ryo Kurokawa et al.
Intrathecal (G4C2)149 delivery in C9orf72-deficient mice yields mild motor dysfunction and ALS/FTD pathological hallmarks [0.03%]
C9orf72缺陷小鼠的蛛网膜下腔(G4C2)149递送产生轻度运动功能障碍和ALS/FTD病理特征
Katelyn A Russell,Amelia A Shahrabi,Suleyman C Akerman et al.
Katelyn A Russell et al.
A repeat expansion in C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), yet existing mouse models incompletely engage spinal regions implicated in disease. Here, an adeno-asso...