Zika virus infection induces a persistent accumulation of Alzheimer's disease-like Tau phosphorylation in adult immunocompetent mice in association with memory and social behavior impairments [0.03%]
寨卡病毒感染与阿尔茨海默病相关的Tau蛋白磷酸化在成年免疫competent小鼠中持续累积及其对记忆和社会行为的影响
Gaetano Calcagno,Zeyni Mansuroglu,Helena Segrt et al.
Gaetano Calcagno et al.
Clinical and epidemiological data support the link between viral encephalitis and neurodegeneration but its causal mechanism remains mostly unknown. Zika virus (ZIKV) is an emerging, neurotropic flavivirus susceptible to induce cognitive im...
Regional wasteosome accumulation across neurodegenerative diseases points to a shared underlying mechanism potentially related to glymphatic insufficiency [0.03%]
神经退行性疾病中的区域废物积累指向潜在的共同发病机制，可能与胶质淋巴循环不足有关
Raquel Alsina,Marta Riba,Marina Sartorio et al.
Raquel Alsina et al.
The glymphatic system plays a key role in clearing waste products from the brain and is essential for maintaining brain homeostasis. When dysfunctional, it appears to contribute to pathological changes that exacerbate brain disorders, inclu...
Challenging anatomical paradigms: unexpected supratentorial localization of posterior fossa B ependymomas identified by DNA methylation [0.03%]
挑战解剖学范式：后颅窝表皮样囊肿出人意料地定位于大脑半球，通过DNA甲基化识别出来
Pedro Piovesan Lago,Mariana Maschietto,Marllon Cindra Sant&#x;Ana et al.
Pedro Piovesan Lago et al.
Molecular subgroups of ependymomas are strongly associated with their primary anatomical compartments, namely the supratentorial region, posterior fossa and spine locations. Although it is generally accepted that posterior fossa ependymomas...
Molecular characteristics of isocitrate dehydrogenase 1 R132C-mutant diffuse gliomas: association with TP53 alterations and Li-Fraumeni syndrome [0.03%]
异柠檬酸脱氢酶1 R132C突变型弥漫性胶质瘤的分子特征：与TP53改变和李-弗拉姆尼综合征的关系
Shinji Yamashita,Fumitaka Matsumoto,Kiyotaka Saito et al.
Shinji Yamashita et al.
Background: The non-canonical isocitrate dehydrogenase 1 (IDH1) R132C mutation is rare in diffuse gliomas but appears to be enriched in tumors associated with Li-Fraumeni syndrome (LFS), which is caused by germline tumor ...
Phenotype-specific muscle proteomic profiling in titinopathies [0.03%]
Titinopathy肌病的表型特异性肌肉蛋白质组学谱型分析
Aurélien Perrin,Marie-Rocio Casenave-Camgaston,Baptiste Rabillard et al.
Aurélien Perrin et al.
Titinopathies are complex neuromuscular disorders with multiple phenotypes. The gene's size, comprising 364 exons, as well as the protein's size of 3.8 MDa and its extensive network of protein interactors, are key factors underlying this co...
MET-associated immune prognostic signature predicts survival and guides personalized therapy in glioma [0.03%]
与MET相关的免疫预后标志物可预测胶质瘤的生存率并指导个性化治疗
Ying Zhang,Chengjun Zheng,Qiaodong Chen et al.
Ying Zhang et al.
Glioma is an aggressive malignancy characterized by an immunosuppressive tumor microenvironment (TME) that drives therapeutic resistance. MET alterations promote tumor progression and immune evasion, yet their clinical implications in gliom...
Nanopore-based DNA methylation profiling for rapid molecular classification of NOS/NEC CNS tumors: multi-institutional evaluation using FFPE archives and frozen tissues [0.03%]
基于纳米孔的DNA甲基化谱分析快速分子分类NOS / NEC中枢神经系统肿瘤：使用FFPE档案和冷冻组织进行多机构评估
Wanming Hu,Jin Zhu,Hang Li et al.
Wanming Hu et al.
Background: DNA methylation profiling has become crucial for accurate classification of CNS tumors, yet Illumina EPIC arrays are restricted by long turnaround times, batching requirements, and limited accessibility in non...
Correction to: Induction of CNS α-synuclein pathology by fibrillar and non-amyloidogenic recombinant α-synuclein [0.03%]
Correction to: 通过纤维状和非淀粉样原纤维重组α-突触核蛋白诱导中枢神经系统α-突触核蛋白病理学
Amanda N Sacino,Mieu Brooks,Nicholas H McGarvey et al.
Amanda N Sacino et al.
Published Erratum
Acta neuropathologica communications. 2026 Jun 29;14(1):136. DOI:10.1186/s40478-026-02325-8 2026
A rare missense variant impacting NEK1 kinase function is associated with ALS [0.03%]
一个影响NEK1激酶功能的罕见错义变异与ALS相关
David Brenner,Anna Ponomarenko,Iris Petrut et al.
David Brenner et al.
Heterozygous truncating loss-of-function (LoF) variants in NEK1 are a known cause of amyotrophic lateral sclerosis (ALS). NEK1 encodes the pleiotropic serine/threonine kinase NIMA-related kinase 1, and prior in vitro studies have implicated...
VGLL-fused intraparenchymal schwannoma with EWSR1::VGLL1 fusion: integrated clinicopathological and molecular characterization [0.03%]
融合EWSR1::VGLL1的VGLL1融合型神经鞘瘤的综合临床病理学及分子特征分析
Ryosuke Ikemachi,Yohei Inoue,Yoshihiro Otani et al.
Ryosuke Ikemachi et al.
Intraparenchymal schwannomas are rare intracranial tumors confined to the brain parenchyma without connection to peripheral nerves. While conventional schwannomas are often associated with NF2 inactivation, the pathogenesis of intraparenchy...