NOP56 is essential for mammalian generation and maintenance of multiple central nervous systems, associated with SCA36 pathology [0.03%]
NOP56对哺乳动物多种中枢神经系统的产生和维持是必不可少的，与SCA36病理相关
Kosuke Matsuzono,Yasumitsu Nagao,Chihiro Sarai et al.
Kosuke Matsuzono et al.
NOP56, a core nucleolar component involved in small nucleolar ribonucleoprotein assembly, has been genetically implicated in spinocerebellar ataxia type 36. However, the role of NOP56 in mammalian neurodevelopment and disease remains poorly...
The modulation of the blood-brain barrier by focused ultrasound stimulates oligodendrogenesis [0.03%]
经聚焦超声调节的血脑屏障可促进少突胶质细胞发生
Kate Noseworthy,Joseph Silburt,Alessia Apa et al.
Kate Noseworthy et al.
Focused ultrasound (FUS) combined with intravenous microbubbles (MB) enables precise and reversible modulation of the blood-brain barrier (BBB) to enhance the delivery of therapeutics from the blood to targeted brain areas. Beyond this appl...
Repeated mild spinal cord contusions exacerbate tauopathy development in PS19 mice [0.03%]
重复性轻度脊髓损伤加重PS19tau小鼠模型的Tau病变发展
Nicolas Halloin,Nicolas Debortoli,Lidia Lopez-Gutiérrez et al.
Nicolas Halloin et al.
Growing evidence indicates that traumatic brain injury constitutes a significant risk factor for the development of age-related tauopathies, yet the consequences of repeated mild spinal cord injuries (rmSCI) remain insufficiently explored. ...
Cross-disease LC-MS/MS plasma proteomics identifies reproducible shared and disease-enriched biomarker signatures in neurodegenerative disorders [0.03%]
跨疾病LC-MS/MS血浆蛋白质组学鉴定神经退行性疾病中可重复的共享和疾病富集的生物标志物签名
Youngtae Choi,Shinrye Lee,Janbolat Ashim et al.
Youngtae Choi et al.
Neurodegenerative diseases (NDDs) exhibit considerable molecular heterogeneity, making it difficult to pinpoint robust, disease-specific biomarkers. Although proteomic studies have deepened our understanding of individual disorders, systema...
Matrix metalloprotease-9 modulates microglial/macrophage responses in murine brain demyelination [0.03%]
基质金属蛋白酶-9调节小鼠脑脱髓鞘病程中微胶质细胞/巨噬细胞的反应
Eline Bernaerts,Amber De Visscher,Sam Vanherle et al.
Eline Bernaerts et al.
Multiple sclerosis (MS) is a chronic autoimmune disorder, in which the immune system targets the protective myelin sheath surrounding axons in the brain, spinal cord and optic nerve, leading to demyelination and ultimately neurodegeneration...
Integrated proteogenomic profiling reveals coordinated differential expression signatures during neuroinflammation [0.03%]
整合的蛋白质组基因组分析揭示了神经炎症过程中的协同差异表达特征
Elena Prepoudis,Sabina Pfister,Andreas Hofmann et al.
Elena Prepoudis et al.
Background: Experimental autoimmune encephalomyelitis (EAE) is a key model of autoimmune neuroinflammation, yet an integrated characterization of transcriptional and proteomic dysregulation of the CNS has been missing. ...
Laser microdissection-based multi-omics integration unveils the pathological atlas and tumor differentiation network of adamantinomatous craniopharyngioma [0.03%]
基于激光微解剖的多组学整合揭示了牙龈母细胞瘤的病理图谱和肿瘤分化网络
Bowen Wu,Chunming Xu,Chenxing Yang et al.
Bowen Wu et al.
Although adamantinomatous craniopharyngioma (ACP) is a histologically benign intracranial tumor, its invasive growth pattern, characterized by finger-like protrusions, leads to a poor prognosis. In-depth analysis of the heterogeneity of the...
CSF1R inhibition following antibody mediated demyelination has limited impact on remyelination [0.03%]
抗体介导的脱髓鞘后，CSF1R抑制对再髓鞘化的影响有限
Lisa C Golden,Graham C Peet,Rebecca E Rodriguez et al.
Lisa C Golden et al.
Multiple sclerosis (MS) is a chronic, immune-mediated, demyelinating disease of the central nervous system. B cell depleting treatments are effective MS therapies, and while antibodies may serve as a biomarker, little is known about how the...
NR3C1 promotes group 4 medulloblastoma invasion via activating VCAN [0.03%]
NR3C1通过激活VCAN促进第四组髓母细胞瘤侵袭
Jing Wang,Zichang Zhang,Han Lin et al.
Jing Wang et al.
Approximately 30% of group 4 medulloblastomas (G4-MBs) present with metastasis at diagnosis, yet the molecular mechanisms remain unclear. To elucidate differences of genes' expression between primary tumors of metastatic (M+) and non-metast...