Changes in glial cell phenotypes precede overt neurofibrillary tangle formation, correlate with markers of cortical cell damage, and predict cognitive status of individuals at Braak III-IV stages [0.03%]
胶质细胞表型变化先于明显的神经原纤维缠结形成，与皮层细胞损伤标志物相关，并可预测Braak III-IV期个体的认知状态
Raquel N Taddei,Maria V Sanchez-Mico,Orla Bonnar et al.
Raquel N Taddei et al.
Clinico-pathological correlation studies show that some otherwise healthy elderly individuals who never developed cognitive impairment harbor a burden of Alzheimer's disease lesions (plaques and tangles) that would be expected to result in ...
Kristyn Galbraith,Matija Snuderl
Kristyn Galbraith
DNA methylation of cytosines in CpG sites throughout the genome is an epigenetic mark contributing to gene expression regulation. DNA methylation patterns are specific to tissue type, conserved throughout life and reflect changes during tum...
Integrated proteomic analysis of low-grade gliomas reveals contributions of 1p-19q co-deletion to oligodendroglioma [0.03%]
整合低级别胶质瘤蛋白质组分析揭示了1p-19q共缺失对少突胶质细胞瘤的影响
Derek Wong,Tae Hoon Lee,Amy Lum et al.
Derek Wong et al.
Diffusely infiltrative low-grade gliomas (LGG) are primary brain tumours that arise predominantly in the cerebral hemispheres of younger adults. LGG can display either astrocytic or oligodendroglial histology and do not express malignant hi...
Frontal lobe microglia, neurodegenerative protein accumulation, and cognitive function in people with HIV [0.03%]
HIV患者额叶小胶质细胞、神经退行性蛋白沉积和认知功能损伤的关系研究
Jacinta Murray,Gregory Meloni,Etty P Cortes et al.
Jacinta Murray et al.
Microglia are implicated in Alzheimer's Disease (AD) pathogenesis. In a middle-aged cohort enriched for neuroinflammation, we asked whether microgliosis was related to neocortical amyloid beta (A[Formula: see text]) deposition and neuronal ...
Insulin-like growth factor 5 associates with human Aß plaques and promotes cognitive impairment [0.03%]
胰岛素样生长因子5与人Aß斑块结合并促进认知障碍
Stefanie Rauskolb,Thomas Andreska,Sophie Fries et al.
Stefanie Rauskolb et al.
Risk factors such as dysregulation of Insulin-like growth factor (IGF) signaling have been linked to Alzheimer's disease. Here we show that Insulin-like Growth Factor Binding Protein 5 (Igfbp5), an inhibitory binding protein for insulin-lik...
Acute axon damage and demyelination are mitigated by 4-aminopyridine (4-AP) therapy after experimental traumatic brain injury [0.03%]
氨吡啶能减轻创伤性脑损伤后的轴突破坏和脱髓鞘现象
Kryslaine L Radomski,Xiaomei Zi,Fritz W Lischka et al.
Kryslaine L Radomski et al.
Damage to long axons in white matter tracts is a major pathology in closed head traumatic brain injury (TBI). Acute TBI treatments are needed that protect against axon damage and promote recovery of axon function to prevent long term sympto...
Fibroblast growth factor receptor 4 promotes glioblastoma progression: a central role of integrin-mediated cell invasiveness [0.03%]
成纤维细胞生长因子受体4促进胶质母细胞瘤进程：整合素介导的细胞侵袭性发挥中心作用
Lisa Gabler,Carola Nadine Jaunecker,Sonja Katz et al.
Lisa Gabler et al.
Glioblastoma (GBM) is characterized by a particularly invasive phenotype, supported by oncogenic signals from the fibroblast growth factor (FGF)/ FGF receptor (FGFR) network. However, a possible role of FGFR4 remained elusive so far. Severa...
Thoracic low grade glial neoplasm with concurrent H3 K27M and PTPN11 mutations [0.03%]
同时具有H3K27M和PTPN11基因突变的胸部低级别胶质瘤
Michael G Argenziano,Julia L Furnari,Michael L Miller et al.
Michael G Argenziano et al.
We present the case of a 41-year-old man who developed worsening mid-thoracic back pain and imaging revealed a well-circumscribed intramedullary tumor in the thoracic spinal cord. Subtotal resection was performed, and histopathological anal...
Deep learning from multiple experts improves identification of amyloid neuropathologies [0.03%]
基于多个专家的深度学习改进了对淀粉样神经病理学的识别
Daniel R Wong,Ziqi Tang,Nicholas C Mew et al.
Daniel R Wong et al.
Pathologists can label pathologies differently, making it challenging to yield consistent assessments in the absence of one ground truth. To address this problem, we present a deep learning (DL) approach that draws on a cohort of experts, w...
Longitudinal dynamics of microvascular recovery after acquired cortical injury [0.03%]
获得性皮质损伤后的微血管恢复纵向动力学研究
Xiaoxiao Lin,Lujia Chen,Amandine Jullienne et al.
Xiaoxiao Lin et al.
Acquired brain injuries due to trauma damage the cortical vasculature, which in turn impairs blood flow to injured tissues. There are reports of vascular morphological recovery following traumatic brain injury, but the remodeling process ha...