Secondary peripheral T-cell lymphoma in a patient with DLBCL harboring BLM mutation following CD19/CD22 bispecific CAR-T cell therapy [0.03%]
携带BLM突变的DLBCL患者接受CD19/CD22双特异性CAR-T细胞治疗后发生外周T细胞淋巴瘤secondary Peripheral T-cell Lymphoma）
Xindi Liu,Jia Cong,Xiayu Xia et al.
Xindi Liu et al.
We describe a case of secondary peripheral T-cell lymphoma (PTCL) arising from infused CD19/CD22-4-1BB-CD3ζ-lenti bispecific chimeric antigen receptor (CAR)-T cells in a patient with relapsed or refractory B-cell lymphoma who carried a pat...
UDP-glucuronate decarboxylase 1 promotes tumor immune evasion by accelerating KMT2D loss in hepatocellular carcinoma [0.03%]
UDP-葡萄糖醛酸脱羧酶1通过加速KMT2D在肝细胞癌中的丢失促进肿瘤免疫逃逸
Jiwei Zhang,Yuan Li,Jiafeng Chen et al.
Jiwei Zhang et al.
Background: Immune checkpoint blockade (ICB) targeting the programmed cell death 1 (PD-1)/programmed cell death ligand 1 (PD-L1) axis has shown promise in hepatocellular carcinoma (HCC), but clinical responses are often l...
Amanda Montoya,Meredith L Frank,Peixin Jiang et al.
Amanda Montoya et al.
Background: Cancer immunotherapies have significantly improved treatment efficacy and patient survival by exploiting antigen-specific T cells to eliminate cancer cells. However, current approaches for identifying and isol...
Neutrophil extracellular traps drive local tumor progression and metastasis following thermal ablation in liver cancer via TLR9-mediated inflammatory feedback and immunosuppression [0.03%]
中性粒细胞胞外陷阱通过TLR9介导的炎症反馈和免疫抑制促进肝癌热消融后的局部肿瘤进展和转移
Zhou Tian,Jinchao Zhao,Yueyang Wang et al.
Zhou Tian et al.
Background: Local tumor progression and metastasis substantially compromise the therapeutic efficacy of thermal ablation in liver cancer. Although the inflammatory microenvironment contributes, the specific role of neutro...
Oncogenic PIK3CA mutation enhances tumor immunogenicity through the IRF1-NLRC5-MHC-I axis in urothelial carcinoma [0.03%]
致癌性PIK3CA突变通过IRF1-NLRC5-MHC-I轴增强尿路上皮癌的免疫原性
Yu-Li Su,Shih-Yu Huang,Chung-Wen Kuo et al.
Yu-Li Su et al.
Background: Immune checkpoint inhibitors (ICIs) have significantly improved overall survival in metastatic urothelial carcinoma (mUC). However, predictive biomarkers for therapeutic response remain insufficiently defined....
Pharmacologic activity, safety, and preliminary efficacy of GEN3009, a CD37-targeting DuoHexaBody, in relapsed or refractory B-cell non-Hodgkin's lymphoma [0.03%]
靶向CD37的DuoHexaBody药物GEN3009在复发或难治性B细胞非霍奇金淋巴瘤中的药理活性、安全性和初步疗效研究
Farrukh T Awan,Joshua T Gamse,Marije B Overdijk et al.
Farrukh T Awan et al.
Background: Tetraspanin CD37, highly expressed in mature B-cells, represents an opportunity for therapeutic targeting in B-cell malignancies. GEN3009 (DuoHexaBody-CD37), a humanized biparatopic IgG1 antibody with an E430G...
Emergence of a mixed CAF population by FAP-CD3 T-cell engager limits therapeutic efficacy [0.03%]
针对FAP-CD3的T细胞衔接器因CAF异质性而限制了治疗效果
Robert J Norgard,Joshua R Tagore,Pratha Budhani et al.
Robert J Norgard et al.
Background: Fibroblast activating protein (FAP) expressing fibroblasts are an attractive target for cancer therapeutic depletion and while preclinical depletion shows success, previous modalities have had unsuccessful cli...
IL-18 derived from microwave-ablated osteosarcoma facilitates antitumor response [0.03%]
微波消融骨肉瘤衍生的IL-18促进抗肿瘤应答
Jielong Zhou,Yunhui Zhang,Wenjie Yang et al.
Jielong Zhou et al.
Background: Osteosarcoma (OSA) is the most common primary malignant bone tumor in children and adolescents, while no further improvement in survival has been achieved in the past few decades. Microwave ablation (MWA) is a...
Galectin-9-driven immune evasion constrains radiotherapy-induced systemic antitumor immunity [0.03%]
Galectin-9介导的免疫逃逸限制了放疗诱导的全身抗肿瘤免疫反应
Jiaming Song,Boning Liu,Rodney Cheng-En Hsieh et al.
Jiaming Song et al.
While radiotherapy (RT) is effective for local tumor control, it rarely induces the regression of non-irradiated metastases, a phenomenon known as the abscopal effect. The mechanisms constraining this systemic immune response remain poorly ...
Circumventing Ewing sarcoma tumor microenvironment resistance by IL1RAP CAR-modified TGFβ1-imprinted natural killer cells in combination with IL-15 agonist and anti-GD2 antibody [0.03%]
结合IL-15激动剂和抗GD2抗体，使用经TGFβ1重塑的CAR-IL1RAP自然杀伤细胞规避尤因肉瘤肿瘤微环境耐药性
Wen Luo,Hai-Feng Zhang,Wei Li et al.
Wen Luo et al.
Background: The prognosis of patients with metastatic/relapsed/refractory Ewing sarcoma (ES) is dismal. Natural killer (NK) cells are highly cytotoxic to ES but limited by resistance within the ES tumor microenvironment (...