Immune-cytokine signature predicts survival in patients with advanced melanoma treated with oncolytic adenovirus TILT-123 and chemotherapy and IL-2-free adoptive TIL therapy [0.03%]
免疫细胞因子谱型可以预测经溶瘤腺病毒TILT-123和化疗及无IL-2的过继性肿瘤浸润淋巴细胞治疗后的晚期黑色素瘤患者预后
Lyna Haybout,Tatiana V Kudling,James H Clubb et al.
Lyna Haybout et al.
Background: Metastatic melanoma resistant to immune checkpoint inhibitors remains difficult to treat, and while adoptive tumor-infiltrating lymphocyte (TIL) therapy has shown durable responses, its reliance on lymphodeple...
T-cell receptor repertoires against HLA class I-restricted minor histocompatibility antigens are highly diverse with a small subset of public clonotypes [0.03%]
针对HLA-I限制性次要组织相容性抗原的TCR谱库具有高度多样性，但包含少量公共克隆型
Kyra J Fuchs,Marian van de Meent,Michel G D Kester et al.
Kyra J Fuchs et al.
Background: Allogeneic hematopoietic stem cell transplantation (alloHSCT) can be a curative treatment for hematological diseases. After HLA-matched alloHSCT, donor T cells may recognize minor histocompatibility antigens (...
AARS1-mediated lactylation reprograms macrophage lipid metabolism to restrict antitumor immunity [0.03%]
AARS1介导的乳酰化重构巨噬细胞脂质代谢以限制抗肿瘤免疫反应
Zhaofeng Xiao,Lijun Meng,Shengjun Xu et al.
Zhaofeng Xiao et al.
Background: Tumor-derived lactate has long been regarded as a metabolic waste product. However, accumulating evidence indicates that lactate also functions as a signaling molecule that actively remodels the tumor immune m...
DNA hypomethylation identifying clinical benefit subgroup of small-cell lung cancer: multi-omics analysis of a phase II trial with durvalumab plus olaparib as maintenance therapy [0.03%]
DNA低甲基化可识别度伐鲁单抗联合奥拉帕利维持治疗小细胞肺癌临床优势亚组：二期临床试验的多组学分析
Yuanyuan Zhao,Qiming Wang,Bijing Xiao et al.
Yuanyuan Zhao et al.
Background: Long-term survival of extensive-stage small-cell lung cancer (ES-SCLC) remains rare, with most patients experiencing disease progression during maintenance therapy. Poly (ADP-ribose) polymerase (PARP) inhibito...
T cells are critical for pre-metastatic niche formation through the STAT3/IL-17 axis [0.03%]
STAT3/IL-17轴介导的T细胞在前转移灶形成中的关键作用
Maciej Kujawski,Antons Martincuks,Mihae Song et al.
Maciej Kujawski et al.
Background: Pre-metastatic niches composed of mainly myeloid cells are recognized as critical for tumor metastasis. However, whether adaptive immune cells also play an important role in pre-metastatic niche formation rema...
Clinical trial landscape and translational prospects of natural killer cell-based immunotherapy: an analysis based on the INFORMA database [0.03%]
基于INFORMA数据库的天然杀伤细胞免疫治疗临床格局和转化前景分析
Han Sun,Yanni Zhang,Ye Yuan et al.
Han Sun et al.
Natural killer (NK) cell-based immunotherapy is an increasingly important cancer treatment strategy because of its innate cytotoxicity, allogeneic potential, and compatibility with off-the-shelf manufacturing. We analyzed 287 clinical trial...
Circulating B cell and T cell activation states predict clinical outcomes in melanoma and reveal dynamic immune reinvigoration with checkpoint inhibitor immunotherapy [0.03%]
循环B细胞和T细胞活化状态可预测黑色素瘤的临床结果，并揭示检查点抑制剂免疫治疗的动态免疫复苏作用
Lucy Booth,Rebecca Adams,Angela Clifford et al.
Lucy Booth et al.
Background: Nearly half of patients with melanoma do not respond to immune checkpoint inhibitors (CPIs) and many develop immune-related adverse events (irAEs), often forcing treatment discontinuation, and underscoring the...
Streptococcus anginosus-associated kynurenic acid drives PD-1 blockade resistance through an ITGA2-mTOR-CTSV axis in gastric cancer [0.03%]
黏液性角化病酸通过ITGA2-mTOR-CTSV轴驱动胃癌中的PD-1阻断耐药性
Yingxin Ren,Xiang Yu,Jiaqiang Jiang et al.
Yingxin Ren et al.
Background: The tumor microbiota critically shapes responses to immunotherapy; however, the mechanisms by which specific microbial species drive immune checkpoint blockade (ICB) resistance in gastric cancer (GC) remain po...
Targeting GRP75 by natural compound polyphyllin II triggers mitochondrial calcium overload and pyroptosis to potentiate cancer immunotherapy [0.03%]
天然化合物鹅膏毒肽II靶向GRP75触发线粒体钙超载和吡角质以增强癌症免疫治疗
Yuting Wang,Jingwen Dong,Yu Long et al.
Yuting Wang et al.
Background: Immune checkpoint blockade (ICB) therapy has emerged as a pivotal cancer treatment by activating antitumor immunity. However, its clinical efficacy remains limited in many patients, highlighting the need for c...
Lu Liu,Shihao Qi,Liye Shao et al.
Lu Liu et al.
Background: The low response rate to immunotherapy in patients with lung adenocarcinoma is primarily due to tumor immune evasion. The tumor immunosuppressive microenvironment orchestrates this evasion, yet the underlying ...