Biomarker implications of gene editing in hematologic diseases: latest updates from ASH 2025 [0.03%]
基因编辑在血液系统疾病中的生物标志物意义：来自2025年ASH会议的最新更新
Zezhou Zang,Wei Zheng,Ruirong Xu et al.
Zezhou Zang et al.
The 2025 American Society of Hematology (ASH) Annual Meeting highlighted rapid advances in gene editing for hematologic diseases, with increasing emphasis on precision editing and early exploration of in vivo delivery strategies. Beyond tec...
EGF as a non-invasive biomarker of endometriosis: a case control study [0.03%]
表皮生长因子作为子宫内膜异位症的非侵入性生物标志物：一项病例对照研究
Emma R Rashes Gertel,Cassandra C Daisy,Katherine Kaplan et al.
Emma R Rashes Gertel et al.
Endometriosis is a chronic inflammatory condition that affects an estimated 1 in 10 women but is often mis- and underdiagnosed due to its non-specific symptoms and the lack of a non-invasive diagnostic test. This study aimed to identify and...
Identifying the angiogenic receptor expression in mantle cell lymphoma patients and murine models [0.03%]
弥漫大B细胞淋巴瘤中血管生成受体表达的检测及其与临床预后的关系研究
Satishkumar Singh,Yuanfeng Wang,Anuvrat Sircar et al.
Satishkumar Singh et al.
Mantle Cell Lymphoma (MCL) is an aggressive B-cell non-Hodgkin lymphoma, with frequent relapses and shorter responses with every subsequent treatment. MCL depends on growth factors and cytokines derived from microenvironmental cells for its...
Targeting lysosome-dependent cell death in cancer: towards therapeutic strategies [0.03%]
靶向癌症的溶酶体依赖性细胞死亡：通向治疗策略之路
Yang Li,Jiajie Feng,Xinzhu Dong et al.
Yang Li et al.
Lysosomes serve as central degradative hubs in cells, playing critical roles in maintaining protein homeostasis, clearing damaged organelles, and regulating metabolic signaling. Tumor cells heavily rely on lysosomal functions during prolife...
Hanna B Lunding,Anna M Wasynczuk,Yannic C Bartsch et al.
Hanna B Lunding et al.
IgG antibodies contain a conserved N-linked glycosylation site at Asn297 in the Fc region, and variations in Fc glycosylation critically influence antibody effector functions. While inflammatory signals during immunization are known to redu...
Disrupted glutathione homeostasis in the pathogenesis of TTR-V30M amyloidosis [0.03%]
谷胱甘肽稳态紊乱在TTR-V30M型淀粉样变病发病机制中的作用
Anushree Bachhar,Gabriella Johannson,Melisnur Sahin et al.
Anushree Bachhar et al.
Background: Transthyretin (TTR) amyloidosis is a progressive, life-threatening disorder caused by extracellular deposition of amyloid fibrils derived from the plasma protein TTR. Inherited forms are associated with destab...
Molecular PET imaging of integrin αvβ6 reveals biliary and fibrotic changes in preclinical MASH [0.03%]
分子PET影像整合素αvβ6揭示了胆管和纤维化在MASH临床前模型中的变化
Xiaoyi Wang,Mengqi Wang,Pengzhe Han et al.
Xiaoyi Wang et al.
Background: The progression of metabolic dysfunction-associated steatohepatitis (MASH) involves complex crosstalk among hepatocellular injury, inflammation, and ductular reaction-a process characterized by biliary epithel...
The JAK-STAT pathway in allergic diseases: from pathogenesis to targeted therapy [0.03%]
jak-stat信号通路在过敏性疾病中的作用：从发病机制到靶向治疗
Yu Chen,Junying Hu,Xingchen Liu et al.
Yu Chen et al.
The JAK-STAT signaling pathway serves as a central hub in the pathogenesis of various allergic diseases, including atopic dermatitis, allergic rhinitis, and asthma. It mediates signal transduction of key inflammatory cytokines, such as IL-4...
Guided immunotherapy for residual solid tumor: integrating platelets and CAR T cells to reduce post-surgical recurrence [0.03%]
免疫治疗残余肿瘤复发：整合血小板和CAR-T细胞减少术后复发
Farshad Heydari,Hoda Zendehdel,Mahsa Manafi Varkiani et al.
Farshad Heydari et al.
Postoperative recurrence remains a major obstacle to durable remission in patients with solid tumors, even after complete macroscopic resection. Growing evidence suggests that surgery creates a transient yet highly permissive biological win...
Immunological decoding of adult T cell leukemia - its cell of origin and oncogenesis [0.03%]
成人T细胞白血病的免疫学解码及其起源细胞和致癌机制
Toshiyuki Hori
Toshiyuki Hori
Adult T cell leukemia (ATL) is defined as a mature T cell neoplasm caused by human T cell leukemia virus type 1 (HTLV-1) and has been ascribed to the HTLV-1 gene products. However, the presence of asymptomatic carriers (ACs) accounting for ...