Aqueous-stable Mn(II)-MOF nanoparticles with high r1 relaxivity and biocompatibility: a novel T1 MRI contrast agent [0.03%]
一种新型T1核磁共振造影剂：稳定性的Mn(II)-MOF纳米粒子具有高r1弛豫率和生物相容性
Jacob M Lessard,Dylan Pyle,Jeffrey Bowen et al.
Jacob M Lessard et al.
The demand for safe, effective, and multifunctional magnetic resonance imaging (MRI) contrast agents (CAs) continues to drive the search for gadolinium-free alternatives. Here, we report the development of BVR-19-Mn, a novel, hydrolytically...
Molecularly imprinted polymer-integrated nanozymes for biosensing: advances and prospects [0.03%]
分子印迹聚合物集成纳米酶在生物传感中的应用：进展与展望
Shaemaa Hadi Abdulsada,Alvaro Garcia Cruz,Christopher Zaleski et al.
Shaemaa Hadi Abdulsada et al.
Nanozymes engineered nanomaterials with enzyme-like catalytic activity-have emerged as cost-effective and stable alternatives to enzymes. However, their broad substrate range and lack of specificity limit their utility in precision biosensi...
Intelligent biomaterials for periodontitis and peri-implantitis therapies: stimuli-responsive strategies targeting inflammation and regeneration [0.03%]
用于牙周炎和种植体周围炎治疗的智能生物材料：针对炎症和再生的刺激响应策略
Weili Li,Maoxue Li,Tianlei Cai et al.
Weili Li et al.
Periodontitis and peri-implantitis, driven by dysbiotic biofilms and aberrant host immune responses, lead to pathological inflammation and alveolar bone resorption. Conventional therapies targeting microbial debridement and inflammation con...
Engineering of a graphene oxide-based 2D platform for immune activation and modulation [0.03%]
基于氧化石墨烯的二维平台用于免疫激活和调节的构建工程研究项目名称：基于氧化石墨烯的二维免疫激活及调制工程
Despoina Despotopoulou,Maria Stylianou,Luis M Arellano et al.
Despoina Despotopoulou et al.
Nanoscale-based tools for immunomodulation are expected to offer more targeted and safer approaches to achieve clinically effective manipulation of the local and systemic immune environment. In this study, we aimed to design nanoscale const...
Tendon-derived extracellular vesicles enhance TDSC activity and alleviate inflammatory response: a pathway to promote tendon regeneration [0.03%]
肌腱源性细胞外囊泡增强TDSC活性并减轻炎症反应：促进肌腱再生的新途径
Hui-Min Liu,Min Zhu,Jie Wang et al.
Hui-Min Liu et al.
Tendon-derived stem cells (TDSCs) are pivotal in tendon regeneration, yet their therapeutic potential is hindered by inherent challenges such as erroneous differentiation and functional impairment under oxidative stress and inflammatory con...
Development of antibacterial hydrogel using endophytic Alternaria fungus extract isolated from Australian native plant [0.03%]
从澳大利亚本土植物中分离内生Alternaria菌提取物制备抗菌水凝胶研究
Daniel J Caruso,Bita Zaferanloo,Enzo A Palombo et al.
Daniel J Caruso et al.
To address the problems associated with pathogenic bacteria in healthcare settings, the development of novel antibacterial materials is of high priority. For such purposes, endophytic fungi - symbiotic microorganisms residing within healthy...
Decellularized-PRF and multiscale porosity in Si-doped MgP scaffolds: a strategy for enhanced bone regeneration [0.03%]
去细胞化-富生长因子和含多级孔隙的掺硅MgP支架：一种增强骨再生的策略
Pritish Rath,Santanu Mandal,T A Harinarayanan et al.
Pritish Rath et al.
Magnesium phosphate (MgP)-based bioceramics have emerged as promising alternatives to bone substitutes; however, their rapid degradation and insufficient mechanical strength hinder their clinical applications. This study elucidated the fabr...
Dual crosslinked injectable hydrogels with phytic acid coordination for robust underwater adhesion and rapid hemostasis [0.03%]
基于肌醇磷酸酯配位的双交联可注射水凝胶用于坚固的湿面粘接及快速止血
MinRui Tsai,Sen Wang,LiKe Ren et al.
MinRui Tsai et al.
Uncontrolled hemorrhage is a major cause of mortality in traumatic injuries, necessitating the development of efficient and biocompatible hemostatic materials suitable for clinical and emergency applications. Herein, we report a phytic acid...
Dopant concentration-dependent size-controlled spherical Cu2+-doped Zn Au nanocluster assemblies for efficient cancer theragnostic [0.03%]
一种高效的癌症诊疗用铜离子掺杂金纳米团簇组装体及其尺寸调控方法
Santanu Dolai,Sawna Roy,Anumita Paul
Santanu Dolai
Assembled metal nanoclusters are a promising material for imaging and optical applications, but face challenges in anticancer therapy due to poor cellular uptake arising from their large size. To address this, a Cu2+ ion-doping strategy was...
A nanoplatform with H2O2 self-supplying capability for synergistic chemo/enzyme dynamic/chemodynamic therapy of ovarian cancer [0.03%]
一种具有H2O2自供给能力的纳米平台用于协同化疗/酶动/化动卵巢癌治疗
Ruixue Liu,Jing Feng,Qi Chen et al.
Ruixue Liu et al.
Chemodynamic therapy (CDT) and enzyme dynamic therapy (EDT) are effective treatment methods that kill tumor cells by producing large amounts of reactive oxygen species (ROS). However, the endogenous hydrogen peroxide (H2O2) concentration in...