Design and synthesis of ionic tetraphenylbuta-1,3-diene derivatives: photophysical properties and their suitability in biological environments [0.03%]
离子四苯丁烯-1,3-二烯衍生物的设计、合成及光物理性质和生物学适用性研究
Ayan Datta,Asim Bisoi,Prasanta Pal et al.
Ayan Datta et al.
This work presents the rational design and successful synthesis of three ionic tetraphenylbuta-1,3-diene (TPB) derivatives (TPB-Py-butyl, TPB-Py-SO3, and TPB-Py-NMe3) with short alkyl chains, containing different terminal groups. While the ...
Enhanced amperometric detection of tumor biomarker vanillylmandelic acid using NiMoO4@C3N5 hybrid nanostructures [0.03%]
用于肿瘤生物标志物香草基扁桃酸增强型安培检测的NiMoO4@C3N5纳米结构杂化材料
Nirmal Kumar Sakthivel,Sakthivel Kogularasu,Yung-Lung Chen et al.
Nirmal Kumar Sakthivel et al.
Accurate and sensitive detection of tumor biomarkers is critical for early cancer diagnosis and prognosis. In this study, a NiMoO4@C3N5 hybrid nanostructure-modified glassy carbon electrode was developed for the amperometric detection of va...
Nano-delivery systems for photothermal/starvation therapy and enhanced ferroptosis-immunotherapy [0.03%]
用于光热/饥饿治疗和增强铁死亡免疫疗法的纳米递送系统
Lanfu Zheng,Wei Jiang,Shuming Tian et al.
Lanfu Zheng et al.
Photothermal therapy (PTT) represents a non-invasive therapeutic modality with considerable potential for tumor ablation. However, the complex tumor microenvironment (TME) presents substantial challenges to conventional PTT monotherapy. In ...
Rapidly dissolving and detachable microneedles loaded with antimicrobial peptides for acne vulgaris treatment [0.03%]
一种用于治疗痤疮的快速溶解和可分解的载有抗菌肽的微针贴片
Han Zheng,Nian Liu,Tian Zhou et al.
Han Zheng et al.
Acne vulgaris is predominantly caused by Propionibacterium acnes (P. acnes) infection and has a serious impact on the physical and mental health of patients. Conventional treatments like topical and oral drug administrations have their limi...
Microfluidics-based fabrication and targeted motion control of multimodal therapeutic hydrogel capsule microrobots [0.03%]
基于微流控技术的多模态治疗水凝胶胶囊微机器人制备及靶向运动控制
Jinwei Sheng,Han Fang,Shishuai Qiao et al.
Jinwei Sheng et al.
In cancer combination therapy, micro-robot systems that integrate multiple therapeutic functions have emerged as a key direction for overcoming the limitations of traditional treatments. This study proposes a magnetic thermosensitive hydrog...
Multifunctional bioadhesive hydrogels derived from naturally occurring building blocks for wound healing [0.03%]
基于天然构件的多功能生物粘附水凝胶促进伤口愈合
Kunrui Liu,Hengjie Zhang,Bao Xia et al.
Kunrui Liu et al.
Severe hemorrhage and wound inflammation are major risk factors contributing to high mortality after tissue trauma. Therefore, there is an urgent need to develop emergency materials that can rapidly and effectively close wounds while simult...
EGFR-targeted micelles-in-lipopolymersome nanocarriers for overcoming drug resistance in triple-negative breast cancer [0.03%]
用于克服三阴性乳腺癌耐药性的靶向EGFR的聚合物胶束-脂质多聚体纳米载体
Mahiro Morita,Min Soo Kang,Jung Hoon Choi et al.
Mahiro Morita et al.
Triple-negative breast cancer (TNBC) remains a therapeutic challenge due to its aggressive nature, limited treatment options, and propensity for developing multidrug resistance (MDR). To overcome these limitations, a novel micelles-in-lipop...
Solid-phase engineering of molecularly imprinted nanoparticles (NanoMIPs): how template and solid-phase drive polymer composition and binding performance [0.03%]
分子印迹纳米粒子（NanoMIPs）的固相工程：模板和固相如何驱动聚合物组成和结合性能
Teresa Bosch-Tamayo,Tamara M Iakimova,Amy Q Shen et al.
Teresa Bosch-Tamayo et al.
Molecularly imprinted polymer nanoparticles (nanoMIPs) represent a promising class of synthetic recognition elements with growing potential as robust alternatives to antibodies in diagnostic and sensing technologies. Despite widespread use,...
Chao Wan,Gege Tian,Mingjie Wang et al.
Chao Wan et al.
Eyedrop-based delivery of therapeutic agents provides promising benefits in treating ocular diseases. Conventional topical delivery strategies rely on the passive diffusion of drugs, which is limited in the retention of the drug on the corn...
A nuclear-staining, water-soluble, polycationic two-photon DNA probe for identifying dead neuronal cells and monitoring traumatic brain injury [0.03%]
一种用于识别死亡神经元细胞和监测创伤性脑损伤的核染色、亲水、多阳离子双光子DNA探针
Ziwei Zhang,Yumeng Yang,Zhen Shi et al.
Ziwei Zhang et al.
Neuronal cells are in most parts exempt from the daily flux of cell birth and death. The identification of dead neuronal cells is essential for facilitating our understanding of the types, mechanisms, and roles of neuronal cell death in phy...