mRNA-LNP vaccines: rational design, delivery optimization, and clinical translation [0.03%]
mRNA脂质纳米粒递送系统的设计优化及临床应用
Sangni Jiang,Zhihui Lu
Sangni Jiang
Messenger RNA (mRNA) vaccines face core challenges including low-delivery efficiency and immunogenicity, limiting their wide-ranging applications in infectious disease prevention and cancer therapy. Lipid nanoparticles (LNPs), the most clin...
A modular two-component protein cage for spatially organized enzymatic assembly and enhanced metabolic flux [0.03%]
一种模块化两组件蛋白笼用于酶的空间组织装配和增强代谢通量
Lingqin Wang,Jian Gao,Xiao Ma et al.
Lingqin Wang et al.
Organizing enzymes on self-assembled protein cages offers a promising strategy to replicate nature's catalytic efficiency. However, most existing studies have focused on the functionalization of one-component protein cages. Here, we present...
Polydopamine coating for anchoring icariin-regulated CF/PEEK with enhanced cytocompatibility and osteogenic activity [0.03%]
聚多巴胺涂层用于固定载淫羊藿素的.cf/peek复合物以增强其细胞相容性和成骨活性
Jingfeng Sun,Jinying Li,Peining She et al.
Jingfeng Sun et al.
Bioactivity is an important factor to be considered for orthopedic implants as it determines the success of the implant. Polyetheretherketone (PEEK), an orthopedic biomaterial, has been widely used in biomedical engineering. However, unsati...
A MOF-derived iron oxide nanorod platform for multiplexed detection of ovarian cancer extracellular vesicle biomarkers [0.03%]
基于金属有机框架的铁氧化物纳米棒平台用于检测卵巢癌外泌体生物标志物多重检测
Emtiaz Ahmed,S M Azad Hossain,Yusuf Valentino Kaneti et al.
Emtiaz Ahmed et al.
High-grade serous ovarian cancer (HGSOC) is a highly aggressive malignancy often diagnosed at an advanced stage due to the absence of early symptoms and effective diagnostic tools. Extracellular vesicles (EVs) secreted by tumour cells carry...
A multifunctional IL@MOF composite-based hydrogel for enhanced transdermal drug delivery of 5-fluorouracil [0.03%]
一种用于增强5-氟尿嘧啶经皮给药的多功能IL@MOF复合材料基水凝胶
Ishani Pandya,Vidhi Joshi,Raviraj Pansuriya et al.
Ishani Pandya et al.
Advances in biomaterial-based transdermal drug delivery systems (TDDSs) are unlocking new possibilities for cancer therapy by enhancing skin permeability and enabling sustained drug release while minimizing systemic side effects. In this st...
Development of an optical microneedle device embedding sub-nanoliter volumes of boronic acid-based fluorescent hydrogel [0.03%]
一种基于硼酸的荧光水凝胶光学微针器件的开发(embedding sub-nanoliter volumes)
Masahiro Fukuhara,Hiroaki Takehara,Kevin Barthelmes et al.
Masahiro Fukuhara et al.
Although the diagnostic utility of interstitial fluid (ISF) has been extensively explored, collecting and sensing ISF remains challenging. Microneedle devices offer a promising approach as a minimally invasive method to obtain ISF in a smal...
Development and in vitro/ in vivo evaluation of a triply periodic minimal surface-based 3D-printed anti-infective bone scaffold with spatiotemporally controlled osteogenesis [0.03%]
一种用于时空可控成骨的基于三重周期极小曲面的抗感染骨三维打印支架及其体外和体内评价
Peijie Zhao,Mei Tian,Huan He et al.
Peijie Zhao et al.
Infectious bone defects (IBDs), marked by the concurrent presence and progressive aggravation of both bone infection and bone loss, represent a significant clinical challenge. Traditional staged treatment, namely initial infection control f...
Microstructure-tailored β-tricalcium phosphate scaffolds utilize degradation-guided osteoclast suppression to accelerate bone regeneration [0.03%]
微结构导向的β-三钙磷酸盐骨支架通过降解调控成骨细胞分化促进加速骨再生修复
Qiji Lu,Fansen Zeng,Jingjing Diao et al.
Qiji Lu et al.
β-Tricalcium phosphate (β-TCP) has been a valuable artificial bone material in clinical applications owing to its bioactivity, osteoconductivity, and degradability. However, the inappropriate degradation rate of β-TCP implants is one of ...
Focused ultrasound propulsion of acoustically active nanoparticles into gelatin hydrogels [0.03%]
聚焦超声波驱动声学活性纳米颗粒进入明胶水凝胶中
Talaial B Alina,Shane D Curry,Sven A Saemundsson et al.
Talaial B Alina et al.
Dense biological tissues present formidable transport barriers that limit therapeutic penetration. Ultrasound-mediated propulsion can help to cross these barriers, but the presence of viscoelastic media can dampen ultrasonic cavitation and ...
Discovery, biological evaluations, and modified applications of peptide AVHS derived from dental plaque biofilms [0.03%]
来自牙菌斑生物膜的肽AVHS的发现、生物学评价及应用改进
Yuan-Meng Yang,Teck-Ek Ho,Wen-Jia Gu et al.
Yuan-Meng Yang et al.
With the growing prevalence of early childhood caries (ECC), there is an urgent need to develop effective strategies for caries prevention. Investigation of oral metabolomic microenvironments among caries-free children could provide valuabl...