Emissive and photothermal poly(N-isopropylacrylamide)-immobilized carbon-nanodots with thermoresponsive drug release properties [0.03%]
具有温度响应释放药物性能的聚[N-异丙基丙烯酰胺]固载碳点及其光热性质研究
Salvatore Petralia,Grazia M L Consoli,Ludovica Maugeri et al.
Salvatore Petralia et al.
This study explores the design and synthesis of an innovative thermoresponsive nanocomposite for applications in drug delivery and controlled release. The nanocomposite core consists of carbon dots (CDs), covered by functionalized agarose u...
Photoactivated bioinspired lipoplexes with a chalcone/flavylium photoswitch enhance siRNA delivery-towards precise spatiotemporal control in gene delivery [0.03%]
紫外线激活的可切换阳离子纳米载体增强siRNA递送向基因治疗时空精确控制前进的重要一步
Dmitriy Moreira,Isabel S Oliveira,Pedro Mateus et al.
Dmitriy Moreira et al.
The efficient delivery of nucleic acids (NAs) remains a major challenge in gene therapy due to their poor stability and limited cellular uptake. Even though non-viral vectors have been pivotal to overcoming some of these challenges, signifi...
Pluronic nanoparticle-modified modular bacterial robots for therapy of tumors and inflammatory bowel disease [0.03%]
用于肿瘤和炎症性肠病治疗的Pluronic纳米颗粒修饰模块化细菌机器人
Jinghao Fan,Lin Huang,Mingkang Liu et al.
Jinghao Fan et al.
Bacterial-mediated drug delivery has emerged as a promising strategy for disease treatment, leveraging bacteria's innate ability to penetrate biological barriers and target diseased tissues. However, existing bacteria-nanoparticle hybrid sy...
3D printable collagen-like protein hydrogels via dynamic covalent assembly for soft tissue engineering [0.03%]
用于软组织工程的基于动态共价组装的仿生胶原蛋白样多肽水凝胶及其3D打印
Mercyjayapriya Jebakumar,Mohandass Pachaiyappan,Chayla L Reeves et al.
Mercyjayapriya Jebakumar et al.
This study presents a novel 3D collagen-like protein/aldehyde-functionalized dextran (CLP-AD) hydrogel designed for tissue engineering. Developed under physiological conditions, the hydrogel forms without harsh crosslinkers or external trig...
Photosensitizer-pendant biotinylated polyester as a nanocarrier for targeted photodynamic therapy [0.03%]
一种光敏剂修饰的生物素化聚酯纳米载体用于靶向光动力治疗
Chhandita Chakraborty,Subhendu Biswas,Anindita Das
Chhandita Chakraborty
Combinatorial cancer therapy that combines photodynamic therapy with chemotherapy has gained tremendous importance in recent times. Reactive oxygen species (ROS) generation in cancer cells via photosensitizer-loaded polymeric nanoparticles ...
Enhanced electrochemical detection of sulfamethoxazole by NaOH-mediated exfoliated boron nitride nanosheets [0.03%]
氢氧化钠插层剥离氮化硼纳米片增强磺胺甲恶唑的电化学检测
V Dhrishya,J S Arya Nair,Arya S Nair et al.
V Dhrishya et al.
Hexagonal boron nitride nanosheets (BNNSs), produced via a simple NaOH-assisted liquid exfoliation of bulk BN (h-BN), have been employed for the first time for the electrochemical (EC) detection of sulfamethoxazole (SMZ), a widely detected ...
Targeted chemo-photodynamic therapy in pancreatic cancer: influence of Ir(III)-complex and ion chelating N^N-ancillary ligand on cell death mechanism [0.03%]
基于靶向化疗光动力治疗的胰腺癌研究：金属离子及含氮螯合配体对细胞死亡机制的影响
Maniklal Shee,K Deepak,Soumik Chatterjee et al.
Maniklal Shee et al.
Ir(III)-based metallo-anticancer complexes offer promising therapeutic strategies with their efficacy fine-tuned through structural modifications, leveraging multitargeted mechanisms of action to reduce resistance compared to traditional ch...
Precision-engineered supramolecular assembly of bio-MOFs to combat antimicrobial resistance [0.03%]
精密工程的生物MOFs超分子组装抗击抗菌抗药性
Bani Preet Kaur,Geetika Jain,Jasleen Kaur et al.
Bani Preet Kaur et al.
The escalating global threat of antimicrobial resistance necessitates the exploration of innovative therapeutic paradigms, wherein bio-metal-organic frameworks (bio-MOFs) have emerged as a promising avenue. The supramolecular assembly of me...
Fabrication of cell culture devices with integrated microfluidic networks via vat multimaterial 3D printing [0.03%]
用于制造集成微流控网络的细胞培养设备的体积多材料3D打印技术
Simona Villata,Chiara Santamaria,Raquel Cue Lopez et al.
Simona Villata et al.
Over the past century, in vitro models such as cell cultures have been fundamental tools in the development of medicine and biology. However, these models are usually cultured in a static configuration that does not consider the complex con...
Matching drug and polymer for efficient delivery of anti-inflammatory drugs: PLGA, polyesteramides, and acetalated dextran [0.03%]
高效输送抗炎药物的药和聚合物匹配：PLGA、聚酯胺及醋酸盐糊精
Lea C Klepsch,Philipp Dahlke,Mira Behnke et al.
Lea C Klepsch et al.
The hydrochalcone derivative MF-15 and the synthetically derived BRP-201 are potent anti-inflammatory active pharmaceutical ingredients (APIs) that suffer from poor bioavailability. This necessitates their incorporation into drug delivery s...