A magnetic multi-enzyme nanoplatform for high-purity collagen preparation through efficient contaminant protein elimination [0.03%]
一种磁性多功能酶纳米平台高效去除污染蛋白制备高纯胶原蛋白
Zibing Zeng,Wenhao Guo,Nannan Wei et al.
Zibing Zeng et al.
The widespread application of collagen in biomedical and tissue engineering is significantly constrained by the co-extraction of non-collagenous proteins during isolation, which compromises its functional integrity and safety profile. Conve...
Synthesis and characterization of an injectable telechelic material for the epiretinal delivery of retinal gene therapies [0.03%]
可注射式两末端活性材料的合成与表征在视网膜基因治疗中的外视网膜递送应用
James H Westbay,Daniel P Bigley,Sushma Sappa et al.
James H Westbay et al.
There is a need to develop safer, more efficient, and targeted strategies for the delivery of retinal gene therapies. Current strategies may require high dose therapeutics administered intravitreally or complex subretinal surgical delivery ...
Strategies to improve intracellular delivery of arginine-rich cell-penetrating peptides [0.03%]
富含精氨酸细胞穿透肽胞内递送策略改善研究
Rachel Anjous,P Kavyashree,Abhishek Saha
Rachel Anjous
Cell-penetrating peptides (CPPs) have been shown to transport diverse cargo molecules across the cell membrane, providing a novel route for cellular uptake. Among the various CPP sequences developed to date, arginine (Arg)-rich CPPs have ga...
An anthracene-based molecular rotor as a theranostic agent for viscosity sensing and imaging-guided photodynamic therapy [0.03%]
一种用于粘度传感和成像引导光动力治疗的苊分子转子疗法诊断剂
Ailada Jantasin,Supranee Watpathomsub,Thitima Pewklang et al.
Ailada Jantasin et al.
Viscosity variations within cellular microenvironments are closely associated with pathological states such as cancer, motivating the development of molecular probes that integrate environmental sensing with therapeutic function. Here, we r...
Toward continuous and non-invasive monitoring: a scoping review of in vitro blood glucose devices from electrochemistry to optics and micro-system integration [0.03%]
从电化学到光学和微系统集成的体外血糖检测设备的研究：迈向连续无创监测
Wanmeng Wang,Chongyu Liu,Peiwen Lin et al.
Wanmeng Wang et al.
Abnormal blood glucose levels trigger acute symptoms and drive long-term complications across vascular, renal, neural, and ocular systems. Overall, this review traces the transition in blood glucose monitoring from fingerstick SMBG to conti...
A tumor-targeting gambogic acid-loaded nanovaccine reprograms the tumor microenvironment for enhanced cancer immunotherapy [0.03%]
一种针对肿瘤的 gambogic 酸纳米疫苗通过重新编程肿瘤微环境来增强癌症免疫治疗
Ning Wang,Xingzhi Han,Xueying Bai et al.
Ning Wang et al.
Nanovaccines for co-delivering antigens and adjuvants have demonstrated certain efficacy in cancer immunotherapy. However, these vaccines are challenged by poor biocompatibility, insufficient targeting ability, and attenuated performance in...
Advances in patterned interface design and bonding performance of 3D-printed dental zirconia ceramics: a review [0.03%]
基于图案化界面设计的齿科用3D打印氧化锆陶瓷结合性能研究进展
Wenshu Zhao,Yichen Li,Chong Wei et al.
Wenshu Zhao et al.
Zirconia ceramics have emerged as a mainstream material in dental restorations due to their excellent mechanical and aesthetic properties. However, their inherent chemical inertness and lack of glass phase result in insufficient interfacial...
Controlled release of bone morphogenetic protein-2 improves motor function after traumatic brain injury in a rat model [0.03%]
控制释放骨形态发生蛋白-2可改善脑外伤大鼠模型的运动功能
Jakob M Townsend,Jasmine Z Deng,Scott Barbay et al.
Jakob M Townsend et al.
Severe traumatic brain injury (TBI) is a life-threatening condition characterized by brain swelling within the cranial vault and commonly treated using a two-stage surgical approach. The interval between surgeries, generally spaced weeks to...
Toward reproducible SERS biosensing: analysing instability origins and mitigation approaches from sample preparation to detection [0.03%]
从样品制备到检测分析表面增强拉曼光谱生物传感再现性的不确定性来源及缓解方法
Aochi Liu,Chenyang Gao,Jing Xue et al.
Aochi Liu et al.
Despite its single-molecule sensitivity, surface-enhanced Raman scattering (SERS) faces critical challenges in spatial and temporal reproducibility that hinder clinical translation in biosensing. This review systematically dissects the orig...
Biodegradable polyurethane nerve conduits functionalized with NDP-MSH-loaded self-assembling peptide hydrogels for peripheral nerve regeneration [0.03%]
负载NDP-MSH的自组装肽水凝胶功能化可降解聚氨酯神经导管促进外周神经再生
Junhong Li,Jinghan Wang,Xirui Long et al.
Junhong Li et al.
Autologous nerve grafting remains the clinical gold standard for segmental peripheral nerve repair, but it is limited by donor-site morbidity and graft availability. Nerve guidance conduits (NGCs) offer a promising alternative for periphera...