Co-encapsulation of probiotics with functional components: design strategies, synergistic mechanisms, biomedical applications, and challenges for industrialization [0.03%]
益生菌与功能组分共包封：设计策略、协同机制、医学应用及产业化挑战
Chenyang Ji,Danyuan Li,Ying Liang et al.
Chenyang Ji et al.
Chronic diseases such as depression, diabetes, inflammatory bowel disease, and colorectal cancer are closely associated with gut microbiota dysbiosis and impaired intestinal barrier function. Probiotic supplementation represents an effectiv...
A biotin-conjugated highly stable cationic viologen derivative for live-cell imaging [0.03%]
一种用于活细胞成像的生物素连接的高度稳定的阳离子维奥ген衍生物
Weijie Song,Wenqiang Ma,Qi Sun et al.
Weijie Song et al.
Traditional cancer imaging modalities cannot achieve ideal diagnostic results. Fluorescence imaging is an emerging modality for tumor imaging because of its high selectivity and sensitivity. However, conventional imaging agents have some dr...
Recent advances in 3D printed bone disease models for pathophysiological modeling, drug discovery, and patient education [0.03%]
基于3D打印的骨病模型在病理生理学建模、药物发现和患者教育中的最新进展
Amey Dukle,Shivi Tripathi,Himansu Sekhar Nanda et al.
Amey Dukle et al.
Bone diseases are the major cause of amputations, leading to reduced quality of life and productivity. Although many drugs are developed to treat these conditions, most fail to reach the market because of the lengthy development process. Th...
Alternating partially quaternized polytriazole amphiphiles: bridging neutral and ionic domains for tunable aggregation [0.03%]
交替部分季𬭸化聚三氮唑两亲分子：中性与离子区域间的互连实现聚集性质的调控
Anastasiia Hubina,Yevheniia Lobko,Ivan Khalakhan et al.
Anastasiia Hubina et al.
Poly(1,2,3-triazole)-based polymers remain underexplored as a versatile platform for biomedical soft materials. Here, we report the modular synthesis of amphiphilic poly(1,2,3-triazole)-co-polytriazolium copolymers (qH-PETH) via copper(I)-c...
Exploring a flexible and cytotoxic drug carrier of cisplatin and 5-fluorouracil for a multitarget therapeutic approach in colorectal cancer [0.03%]
用于结直肠癌多靶点治疗的顺铂和氟尿嘧啶柔性的且具有细胞毒性的载药体系的研究
Sandra Mena-Gutiérrez,Marcos J Araúzo-Bravo,Garikoitz Beobide et al.
Sandra Mena-Gutiérrez et al.
The therapeutic potential of many anticancer drugs is frequently hindered by challenges such as non-specific distribution, suboptimal dosing, and premature degradation, which collectively compromise treatment efficacy. To overcome these lim...
Cellulose microfiber-mediated mesoscale architecture promotes the expansion of patient-derived lung cancer organoids while preserving their malignant characteristics [0.03%]
基于纳米纤维素微纤丝的分层粘附促进肺癌类器官扩增并保持其恶性特征
Chengjing Zhou,Jiaxin Wang,Yongming Zhang et al.
Chengjing Zhou et al.
The crucial role of mesoscale collagen architecture in establishing and expanding patient-derived tumor organoids is well recognized. However, obtaining sufficient mesoscale collagen bundles from patient cancer tissues is challenging due to...
An integrative study to unlock the self-assembling and interaction studies of chromium-based metallo-catanionic surfactant mixtures with cytochrome c [0.03%]
一种用于揭示铬基金属卡特烷离子表面活性剂混合物自组装及其与细胞色素C相互作用的集成研究
Navpreet Kaur,Ganga Ram Chaudhary,Gurpreet Kaur
Navpreet Kaur
Surfactant-protein interactions have ever been a topic of discussion for a number of reasons, but understanding the aggregation of proteins is of utmost importance. Cytochrome c (cyt c) is an important heme protein and is not only involved ...
Microneedle-mediated exosome delivery: a precision strategy in advanced regenerative medicine [0.03%]
用于再生医学的微针介导的外泌体递送：精准医疗的新策略
Xiang Chen,Qiancheng Gu,Liangle Liu et al.
Xiang Chen et al.
In recent years, the application of microneedle delivery systems for extracellular vesicle therapy has emerged as a novel approach in regenerative medicine, particularly for enhancing tissue repair and regeneration. This review delves into ...
Exploiting supercooled medium-chain lipids and surfactant combinations for solid-phase dominant nanostructured lipid carrier production [0.03%]
利用亚稳态中链类脂及表面活性剂组合制备固相占优的纳米结构脂质载体
Daniel Sedough-Abbasian,Jiaming Mu,Jerin George Joseph et al.
Daniel Sedough-Abbasian et al.
Nanostructured lipid carriers (NLCs) are a promising delivery system for poorly water-soluble drugs, including lipophilic peptides. However, NLCs often display unpredictable drug partitioning between solid and liquid lipid phases, potential...
Detection of biogenic amine histamine using a triboelectric nanogenerator integrated biodegradable sensor [0.03%]
基于摩擦纳米发电机的可降解传感器用于生物胺组胺检测
Swati Panda,Heewon Song,Sugato Hajra et al.
Swati Panda et al.
Improperly preserved fish, like tuna or mackerel, can cause Scombroid food poisoning due to the presence of excess histamine, which triggers an allergic reaction in the human body. Although there are several sensitive and reliable histamine...