A multifunctional curcumin-Fe3O4@ZIF-8 nanoformulation as a T2 MRI contrast agent and pH-responsive theranostic platform for targeted ROS generation, radiosensitization, and triple-negative breast cancer treatment [0.03%]
一种多功能姜黄素-Fe3O4@ZIF-8纳米配方作为T2 MRI对比剂和pH响应型诊疗平台，用于靶向ROS生成、放射增敏和三阴性乳腺癌治疗
Ali Rahmani,Aziz Maleki,Rahim Jafari et al.
Ali Rahmani et al.
Triple-negative breast cancer (TNBC) is one of the most aggressive and treatment-resistant malignancies, necessitating the development of innovative therapeutic approaches. Here, we report a multifunctional theranostic nanoformulation (curc...
Development of a magnetically driven microrobot covered with a time-dependent film for colon drug delivery [0.03%]
一种用于结肠药物传输的时间依赖性磁驱微机器人及其开发研究
Xiaoyu Li,Weibin Rong,Lefeng Wang et al.
Xiaoyu Li et al.
Oral administration is an ideal method for drug delivery, but achieving targeted drug delivery to the colon remains a challenge. In this study, a magnetic microrobot incorporating a colon-specific method was developed, featuring both time-d...
Hydrolytic degradation of PEG-based thiol-norbornene hydrogels enables multi-modal controlled release [0.03%]
基于PEG的硫醇-环丁烯水凝胶的水解降解可实现多模式控制释放
Nathan H Dimmitt,Chien-Chi Lin
Nathan H Dimmitt
Poly(ethylene glycol) (PEG) hydrogels crosslinked by orthogonal thiol-norbornene click chemistry have emerged as an ideal platform for tissue engineering and drug delivery applications due to their rapid crosslinking kinetics and excellent ...
An octupolar donor-acceptor dye exploiting aggregation-induced intersystem crossing for efficient ROS generation [0.03%]
一种八配体给受体染料通过聚集诱导的系间窜越高效产生活性氧物种
Dayoung Kang,Yongyang Luo,Tae-Il Kim et al.
Dayoung Kang et al.
Photodynamic therapy (PDT) requires photosensitizers (PSs) that efficiently generate reactive oxygen species (ROS) or otherwise induce cell damage, even under the hypoxic conditions typical of solid tumor environments. Here, we report a hea...
Antimicrobial applications of amphiphilic gold nanoparticles for antibiotic delivery [0.03%]
两亲性金纳米颗粒的抗菌应用及抗生素递送功能
Harita Yedavally,Matteo Gasbarri,Jan Maarten van Dijl et al.
Harita Yedavally et al.
Nanomedicine can offer novel strategies in the fight against antimicrobial resistance. Nano-sized drug carriers can be used to deliver antibiotics to their target to treat infections and some nanomaterials themselves have antimicrobial prop...
pH-responsive injectable nanocomposite hydrogel based on dynamic boronate ester bonds loading Pt-TiO2 nanoparticles and fluorescence probe for synergistic sonodynamic-immunotherapy and imaging of cancer [0.03%]
基于动态硼酸酯键的负载Pt-TiO2纳米粒子和荧光探针的pH响应性注射型纳米复合水凝胶协同声动力免疫治疗及癌症成像
Zhiyi Qian,Yifeng Yuan,Junhang Li et al.
Zhiyi Qian et al.
Cold solid tumors such as breast cancer exhibit low immunogenicity, insufficient T cell infiltration, and an immunosuppressive tumor microenvironment, which limit the effectiveness of conventional immune checkpoint inhibitors. Moreover, the...
Anti-neoangiogenic nanodelivery systems: advances in tumor-based and ophthalmic disease research [0.03%]
抗新生血管纳米输送系统在肿瘤和眼科疾病研究中的应用进展
Bingjie Guo,Zhaokai Li,Junyi Zhou et al.
Bingjie Guo et al.
Abnormal neovascularization plays a critical role in the progression of various diseases, with tumor and ophthalmic neovascularization sharing many core mechanisms. As a result, use of anti-angiogenic drugs has become one of the key therape...
A comprehensive protocol for hydrogel-based bioink design: balancing printability, stability, and biocompatibility [0.03%]
基于水凝胶的生物墨水设计全面协议：平衡可打印性、稳定性和生物相容性
Rency Geevarghese,Joanna Żur-Pińska,Daniele Parisi et al.
Rency Geevarghese et al.
Bioink design is one of the most challenging and time-consuming tasks in 3D bioprinting. This study provides a comprehensive framework balancing key factors such as printability (evaluated through rheological analysis), scaffold mechanical ...
Liposome-functionalized biocompatible polyurethane microspheres with bacteria-capturing traps for comprehensive management of bacterial infections [0.03%]
具有捕菌陷阱的脂质体功能化生物相容性聚氨酯微球用于全面管理细菌感染
Ziyue Ling,Shifan Chen,Zhen Hu et al.
Ziyue Ling et al.
Bacterial infections pose a significant threat to public health, as pathogens and their secreted toxins jointly activate immune responses, and severe cases may develop into sepsis. Effective anti-infective treatment requires comprehensive e...
Multi-component SiO2-P2O5-Na2O-K2O-CaO-SrO-ZnO-CaF2-SrF2 bioactive glass with a lower fluoride content can form strontium-containing fluorapatite: a 19F MAS-NMR analysis [0.03%]
低氟含量的多组分SiO₂-P₂O₅-Na₂O-K₂O-CaO-SrO-ZnO-CaF₂-SrF₂生物活性玻璃可以形成含锶的氟磷灰石：一种¹⁹F MAS-NMR分析方法
Victor Mosquim,David Geoffrey Gillam,Linda Wang et al.
Victor Mosquim et al.
This study aimed to reproduce multi-component glasses with varying concentrations of fluoride [F] and to investigate if Sr-containing apatite (Sr-Ap) or SrF2 would be formed when the glasses were immersed in Tris buffer for 24 h and one wee...