Adverse drug effects observed with vildagliptin versus pioglitazone or rosiglitazone in the treatment of patients with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials [0.03%]
维格列汀与吡格列酮或罗格列酮治疗2型糖尿病患者时观察到的不良药物反应：随机对照试验的系统评价和荟萃分析
Pravesh Kumar Bundhun,Girish Janoo,Abhishek Rishikesh Teeluck et al.
Pravesh Kumar Bundhun et al.
Background: Vildagliptin and pioglitazone/rosiglitazone are emerging Oral Hypoglycemic Agents (OHAs) which are used to treat patients suffering from Type 2 Diabetes Mellitus (T2DM). In this analysis, we aimed to systemati...
Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications : Bamberg, Germany. 23-25 June, 2017 [0.03%]
2017年第8届环磷酸鸟苷生成物、效应器和治疗作用国际会议摘记德国班贝格市. 2017年6月23日至25日
G. Todd Milne;on behalf of the Ironwood team;Peter Sandner,Kathleen A. Lincoln,
G. Todd Milne;on behalf of the Ironwood team;Peter Sandner
Haloperidol affects bones while clozapine alters metabolic parameters - sex specific effects in rats perinatally treated with phencyclidine [0.03%]
卤operidol影响骨骼而氯氮平改变代谢参数-青春期前用苯环利定处理的大鼠的性别特异性效应
Tatjana Nikolić,Milan Petronijević,Jelena Sopta et al.
Tatjana Nikolić et al.
Background: The presentation of schizophrenia (SCH) symptoms differs between the sexes. Long-term treatment with antipsychotics is frequently associated with decreased bone mineral density, increased fracture risk and met...
Estrogen and soy isoflavonoids decrease sensitivity of medulloblastoma and central nervous system primitive neuroectodermal tumor cells to chemotherapeutic cytotoxicity [0.03%]
雌激素和大豆异黄酮降低髓母细胞瘤和中枢神经系统原始神经外胚层肿瘤细胞对化疗药物的敏感性
Scott M Belcher,Caleb C Burton,Clifford J Cookman et al.
Scott M Belcher et al.
Background: Our previous studies demonstrated that growth and migration of medulloblastoma (MB), the most common malignant brain tumor in children, are stimulated by 17β-estradiol. The growth stimulating effects of estro...
Rosiglitazone increases endothelial cell migration and vascular permeability through Akt phosphorylation [0.03%]
罗格列酮通过Akt磷酸化增加内皮细胞迁移和血管通透性
Yun Hyi Ku,Bong-Jun Cho,Min Joo Kim et al.
Yun Hyi Ku et al.
Background: Thiazolidinediones (TZDs), peroxisome proliferator-activated receptor-γ (PPAR-γ) agonists, exhibit anti-inflammatory and antioxidant properties and inhibit endothelial inflammation and dysfunction, which is ...
René Fahrner,Anika Möller,Adrian T Press et al.
René Fahrner et al.
Background: Taurolidine has been used for peritonitis, oncological and catheter-lock treatment because of its anti-inflammatory properties. It has been suggested that taurolidine has no severe side-effects, but after long...
Evaluation of pharmacotherapy complexity in residents of long-term care facilities: a cross-sectional descriptive study [0.03%]
长期护理机构居民用药复杂性的评估：一项横断面描述性研究
Vanessa Alves-Conceição,Daniel Tenório da Silva,Vanessa Lima de Santana et al.
Vanessa Alves-Conceição et al.
Background: Polypharmacy is a reality in long-term care facilities. However, number of medications used by the patient should not be the only predictor of a complex pharmacotherapy. Although the level of complexity of pha...
β adrenergic receptor/cAMP/PKA signaling contributes to the intracellular Ca2+ release by tentacle extract from the jellyfish Cyanea capillata [0.03%]
海月水母Cyanea capillata触须提取物诱导的内向钙离子释放与β-肾上腺素能受体/cAMP/PKA信号通路的关系研究
Qianqian Wang,Hui Zhang,Bo Wang et al.
Qianqian Wang et al.
Background: Intracellular Ca2+ overload induced by extracellular Ca2+ entry has previously been confirmed to be an important mechanism for the cardiotoxicity as well as the acute heart dysfunction induced by jellyfish ven...
Astaxanthin mitigates cobalt cytotoxicity in the MG-63 cells by modulating the oxidative stress [0.03%]
虾青素通过调节氧化应激缓解钴对MG-63细胞的毒性作用
Dahe Li,Wenwen Tong,Denghui Liu et al.
Dahe Li et al.
Background: With the re-popularity of metal-on-metal (MoM) bearing in recent years, the cobalt toxicity has been a cause for concern in the total hip replacement surgery by both physicians and patients. ...
The inhibitory effect of Isoliquiritigenin on the proliferation of human arterial smooth muscle cell [0.03%]
isoliquiritigenin抑制人动脉平滑肌细胞增殖的作用研究
Tianbao Chen,Shaoxiong Deng,Rong Lin
Tianbao Chen
Background: Isoliquiritigenin (ISL) has various biological activities including as antioxidant and an inhibitor of PI3K/AKT signaling pathway. However, both oxidative stress and activated PI3K/AKT signaling contribute to ...