High prevalence of prescription of psychotropic drugs for older patients in a general hospital [0.03%]
综合医院老年患者精神活性药物的高处方率
Inken Arnold,Kati Straube,Wolfgang Himmel et al.
Inken Arnold et al.
Background: Many elderly patients receive psychotropic drugs. Treatment with psychotropic agents is associated with serious side effects including an increased risk of falls and fractures. Several psychotropic drugs are c...
Frequency, characteristics and risk factors of QT interval prolonging drugs and drug-drug interactions in cancer patients: a multicenter study [0.03%]
抗癌药物延长QT间期及其药药相互作用的多中心研究及风险因素分析
Qasim Khan,Mohammad Ismail,Sehrash Khan
Qasim Khan
Background: Cancer patients may receive a high number of medications with the potential to prolong QT interval and subsequent TdP (torsades de pointes). This study aimed to identify the prevalence of QT prolonging drugs, ...
Multicenter Study
BMC pharmacology & toxicology. 2017 Dec 1;18(1):75. DOI:10.1186/s40360-017-0181-2 2017
Dose-dependent effect of daptomycin on the artificial prolongation of prothrombin time in coagulation abnormalities: in vitro verification [0.03%]
达托霉素对凝血功能异常的假性PT延长的剂量依赖性影响：体外验证研究
Hideki Hashimoto,Makoto Saito,Naoki Kanda et al.
Hideki Hashimoto et al.
Background: Several studies have reported that daptomycin induced artificial prolongation of prothrombin time (PT) in some test reagents, particularly in warfarin users. However, it remains unknown whether the artificial ...
Pharmacokinetic study of single- and multiple-dosing with metolazone tablets in healthy Chinese population [0.03%]
美托拉宗片在中国健康志愿者中的单次和多次给药药代动力学研究
Xueqing Li,Rutao Wang,Yang Liu et al.
Xueqing Li et al.
Background: Metolazone is a diuretic, saluretic and antihypertensive chemical compound from the quinazoline category that possesses medicinal features similar to those of other thiazide diuretic drugs. However, the pharma...
Use of a trigger tool to detect adverse drug reactions in an emergency department [0.03%]
一种触发工具在急诊科用于检测药物不良反应中的应用
Silvana Maria de Almeida,Aruana Romualdo,Andressa de Abreu Ferraresi et al.
Silvana Maria de Almeida et al.
Background: Although there are systems for reporting adverse drug reactions (ADR), these safety events remain under reported. The low-cost, low-tech trigger tool method is based on the detection of events through clues, a...
Methylxanthines induce structural and functional alterations of the cardiac system in zebrafish embryos [0.03%]
甲基黄素诱导斑马鱼胚胎心脏系统结构和功能的改变
Ram Manohar Basnet,Daniela Zizioli,Michela Guarienti et al.
Ram Manohar Basnet et al.
Background: Zebrafish embryos are emerging as a model for pharmacological and toxicological studies. We used zebrafish embryos to study the general toxicity and cardiovascular effects of eight methylxanthines: aminophylli...
Exploring venlafaxine pharmacokinetic variability with a phenotyping approach, a multicentric french-swiss study (MARVEL study) [0.03%]
一项关于文拉法辛药代动力学变异性的表型研究方法的多中心法国-瑞士研究（MARVEL 研究）
Célia Lloret-Linares,Youssef Daali,Sylvie Chevret et al.
Célia Lloret-Linares et al.
Background: It is well known that the standard doses of a given drug may not have equivalent effects in all patients. To date, the management of depression remains mainly empirical and often poorly evaluated. The developm...
Multicenter Study
BMC pharmacology & toxicology. 2017 Nov 7;18(1):70. DOI:10.1186/s40360-017-0173-2 2017
Assessment of utilization pattern of fixed dose drug combinations in primary, secondary and tertiary healthcare centers in Nepal: a cross-sectional study [0.03%]
尼泊尔各级医疗机构固定剂量药物组合使用情况评估：横断面研究
Arjun Poudel,Mohamed Izham Mohamed Ibrahim,Pranaya Mishra et al.
Arjun Poudel et al.
Background: Prescription practices, especially in South Asian countries, have come under investigation for quality. Although there have been no studies in Nepal that have analyzed the prescription pattern of FDCs for diff...
Prescription of potentially inappropriate medications among older people with intellectual disability: a register study [0.03%]
智力障碍老年人不适当药物处方的现状研究
Anna Axmon,Magnus Sandberg,Gerd Ahlström et al.
Anna Axmon et al.
Background: Older people have a greater disease burden and are more likely than younger to be prescribed medications. They are also more sensitive to adverse effects. With this in mind, a range of medications have been su...
Glucagon-like peptide receptor agonists attenuate advanced glycation end products-induced inflammation in rat mesangial cells [0.03%]
人GLP-1受体激动剂通过抑制晚期糖基化终产物诱导的系膜细胞炎症反应发挥肾保护作用
Jui-Ting Chang,Yao-Jen Liang,Chia-Yu Hsu et al.
Jui-Ting Chang et al.
Background: Hyperglycemia-induced advanced glycation end products (AGEs) and receptor for AGEs (RAGE) production play major roles in progression of diabetic nephropathy. Anti-RAGE effect of peroxisome proliferator-activat...