Antinociceptive tolerance to NSAIDs in the anterior cingulate cortex is mediated via endogenous opioid mechanism [0.03%]
前扣带回阿片肽机制介导的非甾体抗炎药痛觉耐受现象研究
Nana Tsiklauri,Natia Pirkulashvili,Ivliane Nozadze et al.
Nana Tsiklauri et al.
Background: In the past decade several studies have reported that in some brain areas, particularly, in the midbrain periaqueductal gray matter, rostral ventro-medial medulla, central nucleus of amygdala, nucleus raphe ma...
Pharmacokinetics comparison of two pegylated interferon alfa formulations in healthy volunteers [0.03%]
两种聚乙二醇干扰素α健康受试者的药代动力学比较研究
Marisa Boff Costa,Paulo Dornelles Picon,Guilherme Becker Sander et al.
Marisa Boff Costa et al.
Background: Several countries have used pegylation technology to improve the pharmacokinetic properties of essential drugs. Recently, a novel interferon alfa-2b protein conjugated to four-branched 12 kDa polyethylene glyc...
Clinical Trial
BMC pharmacology & toxicology. 2018 Jan 4;19(1):1. DOI:10.1186/s40360-017-0192-z 2018
Identification of cryptolepine metabolites in rat and human hepatocytes and metabolism and pharmacokinetics of cryptolepine in Sprague Dawley rats [0.03%]
从大鼠和人肝细胞中鉴定密花剌碱的代谢产物及密花剌碱在Sprague Dawley大鼠中的代谢和药代动力学研究
Arnold Donkor Forkuo,Charles Ansah,David Pearson et al.
Arnold Donkor Forkuo et al.
Background: This study aims at characterizing the in vitro metabolism of cryptolepine using human and rat hepatocytes, identifying metabolites in rat plasma and urine after a single cryptolepine dose, and evaluating the s...
Liraglutide modulates GABAergic signaling in rat hippocampal CA3 pyramidal neurons predominantly by presynaptic mechanism [0.03%]
利拉鲁肽主要通过突触前机制调节大鼠海马CA3锥体神经元的GABA能信号转导
Omar Babateen,Sergiy V Korol,Zhe Jin et al.
Omar Babateen et al.
Background: γ-Aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the brain where it regulates activity of neuronal networks. The receptor for glucagon-like peptide-1 (GLP-1) is expressed in the hippocamp...
The clinical efficacy of Afatinib 30 mg daily as starting dose may not be inferior to Afatinib 40 mg daily in patients with stage IV lung Adenocarcinoma harboring exon 19 or exon 21 mutations [0.03%]
阿法替尼治疗携带19号外显子或21号外显子突变的IV期肺腺癌患者30毫克/天与40毫克/天疗效相当性研究
Chih-Jen Yang,Ming-Ju Tsai,Jen-Yu Hung et al.
Chih-Jen Yang et al.
Background: Afatinib is a second-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI). Compared to cytotoxic chemotherapy, afatinib has been shown to have better efficacy in the treatment of ...
Ibuprofen plasma concentration profile in deliberate ibuprofen overdose with circulatory depression treated with therapeutic plasma exchange: a case report [0.03%]
血流动力学抑制状态下布洛芬过量致中毒并采用治疗性血浆置换清除的病例报告及布洛芬浓度变化特点分析
Stefanie Geith,Bertold Renner,Christian Rabe et al.
Stefanie Geith et al.
Background: Inquiries relating to ibuprofen overdose have more than tripled in the last ten years in our poison control center. Although the vast majority of cases have a benign clinical course, there are few severe or ev...
Head to head comparison of Prasugrel versus Ticagrelor in patients with acute coronary syndrome: a systematic review and meta-analysis of randomized trials [0.03%]
急性冠脉综合征患者中普拉格雷与替格瑞洛对比的系统评价和meta分析
Pravesh Kumar Bundhun,Jia-Xin Shi,Feng Huang
Pravesh Kumar Bundhun
Background: Prasugrel and Ticagrelor are emerging antiplatelet drugs that might have the potential to replace currently used antiplatelet agents. Previous analyses comparing prasugrel with ticagrelor mainly focused on an ...
Improved drug safety through intensive pharmacovigilance in hospitalized pediatric patients [0.03%]
通过住院儿科患者的强化药物警戒工作来提高药品安全性
Alan O Vázquez-Alvarez,Lorena Michele Brennan-Bourdon,Ana Rosa Rincón-Sánchez et al.
Alan O Vázquez-Alvarez et al.
Background: The aim of this study was to detect and analyze Adverse Drug Reactions (ADRs) through Intensive Pharmacovigilance (IPV) in hospitalized pediatric patients to improve drug safety. ...
Generic-reference and generic-generic bioequivalence of forty-two, randomly-selected, on-market generic products of fourteen immediate-release oral drugs [0.03%]
42个随即选择的14种口服即释原研药物 generics 的通用版药品之间的互仿和自仿生物等效性研究
Muhammad M Hammami,Sophia J S De Padua,Rajaa Hussein et al.
Muhammad M Hammami et al.
Background: The extents of generic-reference and generic-generic average bioequivalence and intra-subject variation of on-market drug products have not been prospectively studied on a large scale. ...
Randomized Controlled Trial
BMC pharmacology & toxicology. 2017 Dec 8;18(1):78. DOI:10.1186/s40360-017-0182-1 2017
Effects of metamizole, MAA, and paracetamol on proliferation, apoptosis, and necrosis in the pancreatic cancer cell lines PaTu 8988 t and Panc-1 [0.03%]
metamizole、MAA和对乙酰氨基酚对胰腺癌细胞系PaTu 8988t和Panc-1增殖、凋亡及坏死的影响
Manuela Malsy,Bernhard Graf,Anika Bundscherer
Manuela Malsy
Background: Adenocarcinoma of the pancreas is one of the most aggressive cancer diseases affecting the human body. Recent research has shown the importance of the perioperative phase in disease progression. Particularly d...