Rituximab impedes natural killer cell function in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients: A pilot in vitro investigation [0.03%]
利妥昔单抗妨碍慢性疲劳综合征/肌痛性脑脊髓炎患者自然杀伤细胞的功能：一项初步的体外调查研究
Natalie Eaton,Hélène Cabanas,Cassandra Balinas et al.
Natalie Eaton et al.
Background: A recent in vitro pilot investigation reported Rituximab significantly reduced natural killer (NK) cell cytotoxicity in healthy donors. Chronic fatigue syndrome/Myalgic encephalomyelitis (CFS/ME) is a debilita...
Involvement of methylation of MicroRNA-122, -125b and -106b in regulation of Cyclin G1, CAT-1 and STAT3 target genes in isoniazid-induced liver injury [0.03%]
异烟肼诱导的肝损伤中MicroRNA-122、-125b和-106b甲基化对Cyclin G1、CAT-1以及STAT3靶基因调控的影响
Yuhong Li,Qi Ren,Lingyan Zhu et al.
Yuhong Li et al.
Background: This investigation aimed to evaluate the role of methylation in the regulation of microRNA (miR)-122, miR-125b and miR-106b gene expression and the expression of their target genes during isoniazid (INH)-induc...
A randomised, double-blind, placebo-controlled phase 1 study of the safety, tolerability and pharmacodynamics of volixibat in overweight and obese but otherwise healthy adults: implications for treatment of non-alcoholic steatohepatitis [0.03%]
伏利西班治疗超重和肥胖但其他方面健康的成人受试者I期随机双盲安慰剂对照研究：对非酒精性脂肪肝炎治疗的意义
Melissa Palmer,Lee Jennings,Debra G Silberg et al.
Melissa Palmer et al.
Background: Accumulation of toxic free cholesterol in hepatocytes may cause hepatic inflammation and fibrosis. Volixibat inhibits bile acid reuptake via the apical sodium bile acid transporter located on the luminal surfa...
Proteomic study revealed antipsychotics-induced nuclear protein regulations in B35 cells are similar to the regulations in C6 cells and rat cortex [0.03%]
蛋白组研究发现抗精神病药物诱导的B35细胞核内蛋白质调控与C6细胞和大鼠皮层中的调控类似
Tinchou Li,Mingcheng Lee,Fuming Tsai et al.
Tinchou Li et al.
Background: Based on accumulating evidence, the regulation of protein expression by antipsychotic drugs (APDs) might be closely related to the control of psychotic symptoms when these drugs are used to treat mental disord...
A newly developed oxime K203 is the most effective reactivator of tabun-inhibited acetylcholinesterase [0.03%]
新型肟K203对复活失活的乙酰胆碱酯酶效果最佳
Kamil Kuca,Kamil Musilek,Daniel Jun et al.
Kamil Kuca et al.
Background: Based on in vitro and in vivo rat experiments, the newly developed acetylcholinesterase (AChE) reactivator, K203, appears to be much more effective in the treatment of tabun poisonings than currently fielded o...
Tomatidine and analog FC04-100 possess bactericidal activities against Listeria, Bacillus and Staphylococcus spp [0.03%]
番茄胺及其类似物FC04-100对李斯特菌、芽孢杆菌和葡萄球菌等具有杀菌活性
Isabelle Guay,Simon Boulanger,Charles Isabelle et al.
Isabelle Guay et al.
Background: Tomatidine (TO) is a plant steroidal alkaloid that possesses an antibacterial activity against the small colony variants (SCVs) of Staphylococcus aureus. We report here the spectrum of activity of TO against o...
A case report of clonidine induced syncope: a review of central actions of an old cardiovascular drug [0.03%]
可乐定致短暂性意识丧失的病例报告及一种老心血管药物中枢作用机制的述评
Alexander J Sandweiss,Christopher M Morrison,Anne Spichler et al.
Alexander J Sandweiss et al.
Background: Clonidine is an imidazoline sympatholytic, acting on both α2-adrenergic and imidazoline receptors in the brainstem to induce antihypertensive and negative chronotropic effects in the vasculature and heart res...
Dihydroisotanshinone I combined with radiation inhibits the migration ability of prostate cancer cells through DNA damage and CCL2 pathway [0.03%]
二氢异丹参酮I联合放疗通过DNA损伤和CCL2通路抑制前列腺癌细胞迁移能力
I-Yun Lee,Yin-Yin Lin,Yao-Hsu Yang et al.
I-Yun Lee et al.
Background: Radiotherapy plays an important role in the treatment of prostate cancer. Despite that sophisticated techniques of radiotherapy and radiation combined with chemotherapy were applied to the patients, some tumor...
A mechanism-based pharmacokinetic model of fenofibrate for explaining increased drug absorption after food consumption [0.03%]
基于机制的非诺贝特药代动力学模型，解释餐后药物吸收增多的现象
Hyun-Moon Back,Byungjeong Song,Sudeep Pradhan et al.
Hyun-Moon Back et al.
Background: Oral administration of drugs is convenient and shows good compliance but it can be affected by many factors in the gastrointestinal (GI) system. Consumption of food is one of the major factors affecting the GI...
Randomized Controlled Trial
BMC pharmacology & toxicology. 2018 Jan 25;19(1):4. DOI:10.1186/s40360-018-0194-5 2018
Enoxaparin attenuates doxorubicin induced cardiotoxicity in rats via interfering with oxidative stress, inflammation and apoptosis [0.03%]
依诺肝素通过干扰氧化应激、炎症和凋亡来缓解多柔比星致大鼠心肌毒性
Reem Ali Shaker,Samer Hassan Abboud,Hayder Chasib Assad et al.
Reem Ali Shaker et al.
Background: Doxorubicin (DOX) is commonly used in the treatment of many types of cancers but its cardiotoxicity is limiting its clinical use. Beyond its anticoagulant action, enoxaparin (ENX), a low molecular weight hepar...