Polymyxin B-induced skin hyperpigmentation: a rare case report and literature review [0.03%]
多黏菌素B致皮肤色素沉着1例及文献复习
Guanhao Zheng,Li Cao,Zaiqian Che et al.
Guanhao Zheng et al.
Background: Polymyxin B (PMB), which is regarded as the ultimate antibacterial treatment against some intractable gram-negative bacteria with its outstanding anti-bacterial activities, inflicts several adverse effects on ...
Characterization of differential patient profiles and therapeutic responses of pharmacy customers for four ambroxol formulations [0.03%]
四种氨溴索制剂患者的特征及治疗效果研究
Peter Kardos,Kai-Michael Beeh,Ulrike Sent et al.
Peter Kardos et al.
Background: Ambroxol relieves cough symptoms based on its secretagogue, anti-inflammatory, anti-oxidant, anti-bacterial, anti-viral, immunomodulatory and local anesthetic effects. The present study was designed to explore...
Observational Study
BMC pharmacology & toxicology. 2018 Jul 4;19(1):40. DOI:10.1186/s40360-018-0229-y 2018
Sites of gastrointestinal lesion induced by mycophenolate mofetil: a comparison with enteric-coated mycophenolate sodium in rats [0.03%]
吗替麦考酚酯和肠溶霉酚酸钠所致大鼠胃肠道损伤部位的比较研究
Yichen Jia,Rulin Wang,Long Li et al.
Yichen Jia et al.
Background: Immunosuppressant drugs for renal transplant mycophenolate mofetil (MMF) and enteric-coated mycophenolate sodium (EC-MPS) cause gastrointestinal (GI) disorders. The specific site of GI tract targeted by MMF an...
Structurally simple synthetic 1, 4-disubstituted piperidines with high selectivity for resistant Plasmodium falciparum [0.03%]
结构简单的合成型1,4-二取代的哌啶类化合物可有效对抗抗药性恶性疟原虫
Moses N Ngemenya,Grace Ntube Abwenzoh,Hermia Nalova Ikome et al.
Moses N Ngemenya et al.
Background: Emergence of resistance to artemisinins and some of their combinations in chemotherapy of clinical malaria has intensified the search for novel safe efficacious antimalarial molecules. Fourteen synthetic 1, 4-...
Comparison of topical tofacitinib and 0.1% hypochlorous acid in a murine atopic dermatitis model [0.03%]
一项小鼠特应性皮炎模型中局部外用托法替布和0.1%次氯酸的比较研究
Tomoki Fukuyama,Sarah Ehling,Jenny Wilzopolski et al.
Tomoki Fukuyama et al.
Background: Topical administration of PR022, 0.05% hypochlorous acid (HOCl) in gel has been demonstrated to be beneficial in a chronic murine atopic dermatitis model. In a follow up study we tested a higher concentration ...
Comparative Study
BMC pharmacology & toxicology. 2018 Jul 3;19(1):37. DOI:10.1186/s40360-018-0232-3 2018
Effect of Linagliptin and Voglibose on metabolic profile in patients with Type 2 Diabetes: a randomized, double-blind, placebo-controlled trial [0.03%]
利格列汀和伏格列波糖对2型糖尿病患者代谢谱的影响：随机双盲安慰剂对照试验
Girish Parthan,Shobhit Bhansali,Anura V Kurpad et al.
Girish Parthan et al.
Background: Dipeptidyl peptidase 4 (DPP4) inhibitors improve glycemic control by promoting GLP1-mediated glucose-dependent insulin secretion and suppression of glucagon. Sitagliptin and vildagliptin have been shown to imp...
Randomized Controlled Trial
BMC pharmacology & toxicology. 2018 Jul 3;19(1):38. DOI:10.1186/s40360-018-0228-z 2018
Prevalence of self-medication practice among health sciences students in Kermanshah, Iran [0.03%]
伊朗克尔曼沙赫卫生科学专业学生自我药疗的流行病学研究
Alireza Abdi,Azam Faraji,Fateme Dehghan et al.
Alireza Abdi et al.
Background: The possibility of self-medication is higher in health sciences students than other students because of easy access to drug information resources and relatively sufficient familiarity with various kinds of dru...
The benefit of combinations of oximes for the ability of antidotal treatment to counteract sarin-induced brain damage in rats [0.03%]
多种肟复合使用对缓解大鼠沙林中毒脑损伤的研究及其解毒效果
Filip Caisberger,Jaroslav Pejchal,Jan Misik et al.
Filip Caisberger et al.
Background: The aim of our study was to compare the ability of two combinations of oximes (HI-6 + trimedoxime and HI-6 + K203) with atropine to counteract acute sarin-induced brain damage with the efficacy of antidotal tr...
Causality and preventability assessment of adverse drug events of antibiotics among inpatients having different lengths of hospital stay: a multicenter, cross-sectional study in Lahore, Pakistan [0.03%]
巴基斯坦拉合尔市不同住院时长的入院患者中抗生素不良事件的发生率和可预防性：一项多中心横断面研究
Anum Saqib,Muhammad Rehan Sarwar,Muhammad Sarfraz et al.
Anum Saqib et al.
Background: A large number of hospital admissions are attributed to adverse drug reactions (ADRs) and they are the fifth leading cause of death worldwide. The present study aimed to assess the causality and preventability...
Observational Study
BMC pharmacology & toxicology. 2018 Jun 25;19(1):34. DOI:10.1186/s40360-018-0222-5 2018
Inflammation down-regulates CYP3A4-catalysed drug metabolism in hemodialysis patients [0.03%]
炎症通过下调CYP3A4的活性降低血液透析患者的药物代谢能力
Hadi Molanaei,Abdul Rashid Qureshi,Olof Heimbürger et al.
Hadi Molanaei et al.
Background: Recent studies indicate that inflammation may also affect CYP3A4 activity. Associations of CYP3A4-mediated metabolism of quinine, with inflammatory biomarkers were investigated in patients undergoing maintenan...