Survivability of hospitalized chronic kidney disease (CKD) patients with moderate to severe estimated glomerular filtration rate (eGFR) after experiencing adverse drug reactions (ADRs) in a public healthcare center: a retrospective 3 year study [0.03%]
一项为期三年的回顾性研究：在公共医疗中心住院治疗的中重度肾小球滤过率(eGFR)慢性肾脏病(CKD)患者经历不良药物反应(ADR)后的生存性
Monica Danial,Mohamed Azmi Hassali,Loke Meng Ong et al.
Monica Danial et al.
Background: Accurate identification and routine preventive practices are crucial steps in lessening the incidence of medications and patients related adverse drug reactions (ADRs). ...
Observational Study
BMC pharmacology & toxicology. 2018 Aug 29;19(1):52. DOI:10.1186/s40360-018-0243-0 2018
Purification, characterization and immunogenicity assessment of glutaminase free L-asparaginase from Streptomyces brollosae NEAE-115 [0.03%]
来自NEAE-115链霉菌brollosae的无谷氨酰胺酶L-天冬酰胺酶的纯化、表征及免疫原性评估
Noura El-Ahmady El-Naggar,Sahar F Deraz,Sara M El-Ewasy et al.
Noura El-Ahmady El-Naggar et al.
Background: L-asparaginase is a potential therapeutic enzyme widely used in the chemotherapy protocols of pediatric and adult patients with acute lymphoblastic leukemia. However, its use has been limited by a high rate of...
Risk factors for readmission in patients discharged with outpatient parenteral antimicrobial therapy: a retrospective cohort study [0.03%]
出院时接受门诊输液抗菌治疗患者的再入院风险因素回顾队列研究
Victoria Huang,Jorg J Ruhe,Polina Lerner et al.
Victoria Huang et al.
Background: Outpatient parenteral antimicrobial therapy (OPAT) is a practical and effective way of delivering antimicrobial therapy, but may be associated with significant risk for hospital readmission. This study aimed t...
Gender-differences of in vitro colonic motility after chemo- and radiotherapy in humans [0.03%]
体内外科运动的性别差异
Maria Antonietta Maselli,Antonia Ignazzi,Francesco Pezzolla et al.
Maria Antonietta Maselli et al.
Background: The aim of the present in vitro study was to investigate, in different genders, motor responses in surgical colonic specimens from patients with rectal cancer undergoing and not undergoing chemotherapy with ca...
Potentiating effect of imidacloprid on arsenic-induced testicular toxicity in Wistar rats [0.03%]
乙酰胺对砷致韦斯特大鼠睾丸毒性的增效作用
Lakshay Mahajan,Pawan Kumar Verma,Rajinder Raina et al.
Lakshay Mahajan et al.
Background: It is an established fact that humans and animals are exposed to more than one chemical concurrently from various sources such as food, air and water. In the past, much emphasis was laid on evaluating the toxi...
The impact of vancomycin trough concentrations on outcomes in non-deep seated infections: a retrospective cohort study [0.03%]
万古霉素谷浓度对非深部感染结局的影响：一项回顾性队列研究
Michael Wan,Sandra A N Walker,Elaine Martin et al.
Michael Wan et al.
Background: Guidelines recommending vancomycin trough concentrations > 10 mg/L in non-deep seated infections are based on expert opinion. The objective of this study was to evaluate patients with non-deep seated infection...
"Appropriateness and adequacy of antibiotic prescription for upper respiratory tract infections in ambulatory health care centers in Ecuador" [0.03%]
厄瓜多尔门诊医疗机构上呼吸道感染患者抗生素处方的适宜性和充分性
Xavier Sánchez Choez,María Luciana Armijos Acurio,Ruth E Jimbo Sotomayor
Xavier Sánchez Choez
Background: Upper respiratory tract infections are the leading cause of misuse of antibiotics, a problem that leads to unnecessary adverse events and antibiotic resistance. Antibiotic prescription in Ecuador was analyzed ...
An inhibitor of 11-β hydroxysteroid dehydrogenase type 1 (PF915275) alleviates nonylphenol-induced hyperadrenalism and adiposity in rat and human cells [0.03%]
11-β羟基类固醇脱氢酶类型1抑制剂(PF915275)改善非尼尔酚所致的大鼠和人类细胞的肾上腺肥大和肥胖症
Ling-Ling Chang,Wan-Song Alfred Wun,Paulus S Wang
Ling-Ling Chang
Background: Nonylphenol (NP) is an environmental endocrine-disrupting chemical (EDC) detected in human cord blood and milk. NP exposure in developmental periods results in hyperadrenalism and increasing 11β-hydroxysteroi...
Cationic liposomes induce cytotoxicity in HepG2 via regulation of lipid metabolism based on whole-transcriptome sequencing analysis [0.03%]
基于全转录组测序分析的阳离子脂质体通过调节脂质代谢诱导HepG2细胞毒性
Ying Li,Xiu-Liang Cui,Qing-Shan Chen et al.
Ying Li et al.
Backgroud: Cationic liposomes (CLs) can be used as non-viral vectors in gene transfer and drug delivery. However, the underlying molecular mechanism of its cytotoxicity has not been well elucidated yet. ...
Antiproliferative and proapoptotic effects of DODAC/synthetic phosphoethanolamine on hepatocellular carcinoma cells [0.03%]
Dodac/合成磷乙醇胺对肝癌细胞的抗增殖和促凋亡作用
Arthur Cássio de Lima Luna,Greice Kelle Viegas Saraiva,Gilberto Orivaldo Chierice et al.
Arthur Cássio de Lima Luna et al.
Background: Current studies have demonstrated that DODAC/PHO-S (Dioctadecyldimethylammonium Chloride/Synthetic phosphoethanolamine) liposomes induces cytotoxicity in Hepa1c1c7 and B16F10 murine tumor cells, with a higher ...