Efficacy and safety of the switch of Triumeq® to generic (abacavir + lamivudine) + Tivicay®: data at 24 weeks [0.03%]
Triumeq®(多替拉韦钠/阿巴卡韦/拉米夫定)切换至 generics (阿巴卡韦+拉米夫定)+Tivicay®：24周数据疗效和安全性分析
Julián Olalla,Javier Pérez-Stachowski,Begoña Tortajada et al.
Julián Olalla et al.
Background: Generic drugs may help to support antiretroviral treatment. We want to assess the efficacy and safety at 24 weeks of the change of coformulated (abacavir + lamivudine + dolutegravir) to (abacavir + lamivudine)...
Comparing lethal dose ratios using probit regression with arbitrary slopes [0.03%]
利用任意斜率的probit回归比较致死剂量比
Chengfeng Lei,Xiulian Sun
Chengfeng Lei
Background: Evaluating the toxicity or effectiveness of two or more toxicants in a specific population often requires specialized statistical software to calculate and compare median lethal doses (LD50s). Tests for equali...
Comparative Study
BMC pharmacology & toxicology. 2018 Oct 5;19(1):61. DOI:10.1186/s40360-018-0250-1 2018
The critical interaction between valproate sodium and warfarin: case report and review [0.03%]
关于丙戊酸钠与华法林之间相互作用的病例报告和文献复习
Chenguang Zhou,Yi Sui,Weijin Zhao et al.
Chenguang Zhou et al.
Background: Valproic acid (VPA) and warfarin are commonly prescribed for patients with epilepsy and concomitant atrial fibrillation (AF). When VPA and warfarin are prescribed together, clinically important interactions ma...
Using superparamagnetic iron oxide nanoparticles to enhance bioavailability of quercetin in the intact rat brain [0.03%]
利用超顺磁性铁氧化纳米颗粒增强槲皮素在完整大鼠脑内的生物利用度
Rezvan Enteshari Najafabadi,Nasrin Kazemipour,Abolghasem Esmaeili et al.
Rezvan Enteshari Najafabadi et al.
Background: Quercetin (QT) as a bioactive flavonoid has a potential therapeutic activity for numerous neuronal injuries and neurodegenerative diseases. However, the low absorption rate of QT, especially through the blood-...
Cardiovascular and microvascular outcomes of glucagon-like peptide-1 receptor agonists in type 2 diabetes: a meta-analysis of randomized controlled cardiovascular outcome trials with trial sequential analysis [0.03%]
胰高血糖素样肽-1受体激动剂治疗2型糖尿病患者的心血管和微血管结局：随机对照心血管结局试验的汇总分析及试验序贯分析
Xiaowen Zhang,Fei Shao,Lin Zhu et al.
Xiaowen Zhang et al.
Background: Efficacy trials showed that glucagon-like peptide-1 receptor (GLP1R) agonists reduced metabolic risk factors in addition to glucose lowering, but the cardiovascular and microvascular efficacy of this drug clas...
Anesthetic-sensitive ion channel modulation is associated with a molar water solubility cut-off [0.03%]
与分子溶解度界限相关的麻醉剂敏感离子通道调节作用
Robert J Brosnan,Trung L Pham
Robert J Brosnan
Background: NMDA receptor modulation by hydrocarbons is associated with a molar water solubility cut-off. Low-affinity phenolic modulation of GABAA receptors is also associated with a cut-off, but at much lower molar solu...
Epidemiology of self-medication in Ethiopia: a systematic review and meta-analysis of observational studies [0.03%]
埃塞俄比亚自我药疗流行病学的系统评价和荟萃分析
Mekonnen Sisay,Getnet Mengistu,Dumessa Edessa
Mekonnen Sisay
Background: Self-medication is the use of drugs to treat self-diagnosed disorders and/or symptoms, or the intermittent or continued use of a prescribed drug for recurrent disease or symptoms. This phenomenon is alarmingly...
From population to individuals: a new indicator for evaluating the appropriateness of clinical application of antibiotics [0.03%]
从群体到个体：评估抗生素临床应用适宜性的新指标
Bin Zheng,Na Li,Zhijian Hu et al.
Bin Zheng et al.
Background: This study aims to establish a new indicator based on the anatomical therapeutic chemical/defined daily dose (ATC/DDD) system. Methods: ...
Adverse clinical outcomes associated with double dose clopidogrel compared to the other antiplatelet regimens in patients with coronary artery disease: a systematic review and meta-analysis [0.03%]
双倍剂量氯吡格雷与冠心病患者其他抗血小板方案不良临床结局的关联：系统评价和Meta分析
Xiaojun Zhuo,Bi Zhuo,Shenyu Ouyang et al.
Xiaojun Zhuo et al.
Background: Recently, several newer antiplatelet treatment strategies have been used in patients with coronary artery disease (CAD). Apart from the dual antiplatelet therapy (DAPT) consisting of aspirin and clopidogrel, d...
Effect of astragaloside IV on indoxyl sulfate-induced kidney injury in mice via attenuation of oxidative stress [0.03%]
通过减轻氧化应激黄芪苷IV对硫酸吲哚酚所致小鼠肾脏损伤的影响
Chunlan Ji,Yueming Luo,Chuan Zou et al.
Chunlan Ji et al.
Background: Astragalus membranaceus, a traditional Chinese medicine (TCM), has been widely used in the treatment of chronic kidney disease (CKD) in China. Astragaloside IV is one of the major compounds of Astragalus membr...