Effects of MDMA treatment and cessation on sexual behaviour and testicular functons in male sprague-dawley rats [0.03%]
MDMA治疗及停药对雄性Sprague-Dawley大鼠性行为和睾丸功能的影响
O O Obembe,E T George,R A Mustapha et al.
O O Obembe et al.
Protective mechanism of sevoflurane preconditioning on myocardial ischemia-reperfusion injury by regulating RMRP/miR-206 axis [0.03%]
异氟烷预处理通过调控RMRP/miR-206轴保护心肌缺血再灌注损伤
Shuang Wu,Yuan Lu,Hao Chen et al.
Shuang Wu et al.
Coenzyme Q10 protects against atorvastatin-induced hepatotoxicity via attenuation of oxidative stress and functional modulation of CYP3A1 [0.03%]
辅酶Q10通过减轻氧化应激和调节细胞色素P450 3A1的功能来预防阿托伐他汀引起的肝毒性
Mohammed A Abdel-Rasol,Mohamed S Anwar,Hoda A Taha et al.
Mohammed A Abdel-Rasol et al.
Background: Atorvastatin (ATO) is a widely prescribed lipid-lowering drug, but its use can be limited by hepatotoxicity, potentially linked to metabolism-related mechanisms. The cellular pathways connecting ATO metabolism...
Therapeutic effects of cold plasma-activated water on MCF7 breast cancer tumors in a mouse model [0.03%]
冷等离子活化水对小鼠MCF7乳腺癌肿瘤的治疗作用
Ghada Abd El-Reda,Manal A M Mahmoud,Fatma Abo Zakaib Ali et al.
Ghada Abd El-Reda et al.
Background: Breast cancer is the most common cancer affecting women, and plasma-activated water (PAW) is emerging as a potential therapeutic approach. While early results are encouraging, additional research is necessary ...
Thyroid hormone changes after tumor necrosis factor inhibitor therapy in euthyroid patients with rheumatic diseases [0.03%]
风湿病患者接受肿瘤坏死因子抑制剂治疗后的甲状腺功能变化
Bayram Kizilkaya,Filiz Mercantepe,Jelena Vekic et al.
Bayram Kizilkaya et al.
iRGD-functionalized PLGA nanocomplex co-loaded with paclitaxel and Trametes robiniophila Murr for targeted inhibition of chemoresistant and metastatic signaling gene PDCD4 in colon cancer [0.03%]
载有紫杉醇和灵芝多糖肽的iRGD修饰PLGA纳米复合物用于结肠癌中化疗耐药及转移相关靶基因PDCD4的抑制研究
Li Li,Ying Liu,Xiao Wei et al.
Li Li et al.
Background: Metastasis and chemoresistance remain key challenges in colon tumor management. Integrating transcriptomic screening with molecular modeling may reveal actionable therapeutic targets for rational nanocomplex d...
Computational-experimental repurposing reveals synergistic sorafenib/hydroxychloroquine response in KRAS-mutant breast cancer [0.03%]
计算与实验联合研发揭示了KRAS突变型乳腺癌中索拉非尼/羟氯喹的协同反应
Mohammad M Abdelwahab,Mahmoud Soliman,Amr Nassrallah
Mohammad M Abdelwahab
Background: KRAS mutations are approximately 25% of human cancers, with particularly high incidence in breast and lung cancers, by constitutively triggering MAPK/ERK and PI3K/AKT pathways that advance proliferation, survi...
Preparation, molecular docking, and biological evaluation of radioiodinated cefaclor for inflammation detection [0.03%]
放射性标记头孢克洛的制备、分子对接及生物学评价用于炎症检测
H Hussien,Marwa S El Refaye,H Aglan et al.
H Hussien et al.
Background: Inflammation serves as a natural defense mechanism; however, its persistence can lead to chronic diseases with serious clinical consequences. Early detection of inflammation is therefore critical to slowing di...
7-hydroxy flavones, isolated bioflavonoids, ameliorate LPS-induced AD via inhibition of the NFKB pathway [0.03%]
7-羟基黄酮通过抑制NF-κB途径改善LPS诱导的阿尔茨海默病(AD)
Ashish D Tale,Shirish P Jain,Sagar S Jankar et al.
Ashish D Tale et al.
Background: Neurodegenerative disorders and behavioural abnormalities, including learning and memory issues, are significantly influenced by infection and inflammation. We looked into how 7-hydroxyflavone affected a mouse...