Bifenthrin exacerbates ulcerative colitis via immunotoxicity: network toxicology and experimental validation reveal novel therapeutic targets [0.03%]
联苯菊酯通过免疫毒性加重溃疡性结肠炎：网络毒理学与实验验证揭示新的治疗靶标
Lingxiao Wang,Weixing Zhang,Yifan Kang et al.
Lingxiao Wang et al.
Bifenthrin (BF) is a widely used pyrethroid insecticide and is recognized as an endocrine-disrupting chemical (EDC). Accumulating evidence indicates that long-term exposure to BF can induce a variety of adverse health outcomes. However, its...
Consumption of systemic antibiotics in a tertiary care hospital in Northern Sri Lanka: a five-year trend analysis [0.03%]
斯里兰卡北部一家三级护理医院系统抗生素消耗量的五年趋势分析
Yalini Guruparan,Pavithra Meenadchisundaram,Saranya Amarasingam et al.
Yalini Guruparan et al.
Background: Surveillance of antimicrobial consumption helps to understand the pattern of antibiotic utilisation and plays an essential role in tackling antimicrobial resistance. However, a lack of an established surveilla...
Association of ACEIs/ARBs treatment with clinical outcomes in acute kidney injury: a multicenter retrospective cohort analysis [0.03%]
血管紧张素转换酶抑制剂或血管紧张素受体阻滞剂治疗与急性肾损伤临床结局的关系：多中心回顾性队列分析
Hai Wang,Ji Zhao,Jun-Hua Lv et al.
Hai Wang et al.
Background: ACEIs/ARBs (angiotensin-converting enzyme inhibitors/angiotensin receptor blockers) constituted the cornerstone of therapy for various cardiovascular and renal disorders. The appropriate management of ACEIs/AR...
Population pharmacokinetics of tacrolimus and CYP3A5-driven variability: implications for model-informed dose individualization in pediatric renal transplant recipients [0.03%]
他克莫司的群体药代动力学及CYP3A5引起的个体差异对儿科肾移植受者模型指导下的个性化给药的启示
Lesly Yanira Xajil-Ramos,Jesús Alonso Gándara-Mireles,Mariela Guerra-García et al.
Lesly Yanira Xajil-Ramos et al.
Background: Population pharmacokinetics and pharmacogenomics are essential tools for understanding interindividual variability in tacrolimus exposure in pediatric transplant recipients. Identifying clinical and genetic fa...
Melatonin and cerium oxide nanoparticles additively mitigate capecitabine-induced hepatotoxicity via targeting oxidative stress, apoptosis, and ERK signaling [0.03%]
褪黑素和铈氧化物纳米粒子通过靶向氧化应激、凋亡和ERK信号(additive)减轻卡培他滨诱导的肝毒性
Khalid M Mohany,Heba M Elkady,Nashwa Hamad et al.
Khalid M Mohany et al.
Background: Capecitabine (CAP), a chemotherapy prodrug, is associated with a significant dose-limiting hepatotoxicity. This study evaluated the protective efficacy of melatonin (MEL) and cerium oxide nanoparticles (CeO₂ ...
Clinical effects of lamotrigine combined with duloxetine in the treatment of bipolar depression [0.03%]
拉莫三嗪联合度洛西汀治疗双相抑郁的临床疗效分析
Xiaokang Wang,Shanshan Li,Yuxian Chen et al.
Xiaokang Wang et al.
Objective: This study aims to assess the therapeutic efficacy and safety profile of lamotrigine-duloxetine (LTG + DUL) combination therapy in the treatment of bipolar depression (BD), with a focus on understanding cortiso...
Nanotechnology-based detoxification of profenofos using red blood cell membrane-coated polymeric nanoparticles [0.03%]
基于纳米技术的红血球膜涂层聚合物纳米颗粒清除丙酚霜的方法
Sidra Altaf,Faqir Muhammad,Rao Zahid Abbas et al.
Sidra Altaf et al.
Background: Organophosphate (OP) poisoning poses a critical global health challenge due to the absence of specific antidotes. Profenofos (PRF), an organophosphate pesticide, is associated with severe toxicity and high ris...
Development and application of a simple LC-MS/MS method for therapeutic drug monitoring to guide colistin dosing in critically Ill patients [0.03%]
一种简单的LC-MS/MS方法的研发及应用以指导重症患者多黏菌素的个体化治疗剂量
Yueyuan Wang,Yani Gu,Kai Fan et al.
Yueyuan Wang et al.
Objectives: This study aims to develop a simple, rapid, and cost-effective liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for determining the concentration of colistin in human serum, including its two a...
Tranexamic acid inhibits mitochondrial DNA release and reduces inflammatory response in an in vitro model of OGD/R-induced Caco-2 cell injury [0.03%]
氨甲环酸抑制OGD/R诱导的Caco-2细胞线粒体DNA释放并减少炎症反应
Ziyue Wang,Liman Huo,Hong Liu et al.
Ziyue Wang et al.
Background: Ischemia-reperfusion (I/R) injury of the intestine remains a challenging clinical issue, and there is currently no definitive treatment protocol. Tranexamic acid (TXA), an antifibrinolytic drug used in bleedin...
In-vitro pharmacological and cytotoxic evaluation of genipin-crosslinked human serum albumin nanoparticles loaded with methyltestosterone in MCF-7 breast cancer cells [0.03%]
载有甲基睾丸素的葛根素交联人血清白蛋白纳米粒体外药理和细胞毒性的评估研究
Elena Ganji,Maryam Heydari,Aref Arminfar et al.
Elena Ganji et al.
Background: Breast cancer remains one of the leading causes of cancer-related mortality among women worldwide. Although methyltestosterone (MT) has demonstrated therapeutic potential in hormone-responsive breast cancer, i...