Therapeutic potential of zinc oxide/berberine nanoparticles in mitigating acute respiratory distress syndrome: in vivo and in silico approaches [0.03%]
锌 oxide/小檗碱纳米颗粒在缓解急性呼吸窘迫综合征方面的治疗潜力：体内和分子模拟方法
Maysara S El-Salakawy,Alshimaa A Abd-Elmoneam,Mohammed S Nofal et al.
Maysara S El-Salakawy et al.
Background: Inflammation and oxidative stress strongly contribute to the pathophysiology of acute respiratory distress syndrome (ARDS), which is a life-threatening pulmonary disease. Zinc oxide/berberine nanoparticles (Zn...
Gallic acid lessens kidney injury induced by inorganic arsenic and zinc oxide nanoparticles in rats via controlling electrolyte balance, oxidative stress, and Nrf-2 and HSP-90 expression [0.03%]
没食子酸通过调控电解质平衡、氧化应激及Nrf-2和HSP-90表达减轻大鼠无机砷和锌氧化物纳米颗粒诱导的肾脏损伤
Yasmina M Abd-Elhakim,Mohamed M M Hashem,Khaled Abo-El-Sooud et al.
Yasmina M Abd-Elhakim et al.
Inorganic arsenical compounds, such as arsenic trioxide (ATO), are toxic environmental contaminants that occur widely in soil, water, and biological systems. Besides, zinc oxide nanoparticles (ZNPs) have been recently incorporated in variou...
Dual block evidence of the effects of topiramate, a sulfamate-substituted monosaccharide, on voltage-gated sodium current and hyperpolarization-activated cation current [0.03%]
托吡酯对电压门控钠电流和超极化激活的阳离子电流的双重阻断作用的证据：一种取代的单糖硫酸盐类药物
Ray-Chang Tzeng,Ming-Chi Lai,Sheng-Nan Wu et al.
Ray-Chang Tzeng et al.
Background: Topiramate (TPM) is a sulfamate-substituted monosaccharide known for its wide-ranging effects on epilepsy, neuropathic pain, and migraines. However, its precise influence on plasmalemmal ionic currents, includ...
Exploring the impact of endocrine-disrupting chemicals on erectile dysfunction through network toxicology and machine learning [0.03%]
基于网络毒理学和机器学习探索内分泌干扰物对勃起功能障碍的影响
Zhiyu Liu,Juan Wang,Yuqi Li et al.
Zhiyu Liu et al.
Background: Erectile dysfunction (ED) is a common male sexual disorder with a multifactorial etiology. The exposure to endocrine-disrupting chemicals (EDCs) has been increasingly linked to reproductive health disorders in...
Epidemiology of drug-related liver injury among the elderly: a systematic review and meta-analysis of incidence, and risk factors [0.03%]
老年人药物性肝损伤的流行病学特征：患病率及危险因素的系统评价和 Meta 分析
Yujing Fan,Junfu Zheng,Junnan Gu et al.
Yujing Fan et al.
In vivo acute oral toxicity assessment of novel histone deacetylase 2 inhibitor [0.03%]
新型组蛋白去乙酰化酶2抑制剂的急性经口毒性研究
Padmini Pai,Rachel Savio D&#x;Mello,Shruthi Nayak et al.
Padmini Pai et al.
Histone deacetylases (HDACs) are enzymes responsible for removing acetyl groups from histone proteins, resulting in chromatin condensation and the repression of genes. They regulate the expression of genes, the cell cycle, and multiple cell...
Preparation and characterization of Lactobacillus rhamnosus, Lactobacillus casei, glycyrrhizin, vitamin-D3, and citric acid-loaded mucoadhesive pectin microparticles for the management of dental caries [0.03%]
用于牙齿保健的鼠李糖乳杆菌、干酪乳杆菌、甘草甜素、维生素D3和柠檬酸包载的黏膜粘附果胶微粒的制备与表征
Sumita Mishra,Somnath Ghosh,Koushik Jana et al.
Sumita Mishra et al.
Preconditioning with hydrogen gas produces cardioprotective effects through autophagy activation in rat cardiomyocytes [0.03%]
预处理氢气通过激活自噬产生心脏保护作用的机制研究
Tokuhiro Yamada,Aya Kimura,Takashi Juri et al.
Tokuhiro Yamada et al.
Background: It is controversial whether hydrogen (H2) gas can activate cellular survival cascades and autophagy in the myocardium. This translational study aimed to investigate the hypothesis that preconditioning with inh...
The effect of acetyl tributyl citrate on coronary heart disease: a comprehensive computational analysis [0.03%]
乙基三丁基柠檬酸酯对冠心病的影响：一种全面的计算分析方法
Xu Ma,Yingying Liu,Zhen Hua et al.
Xu Ma et al.
Background: Recent research suggests a link between acetyl tributyl citrate (ATBC) exposure and an increased risk of coronary heart disease (CHD). Objecti...
Biochemical, histopathological, and immunohistochemical study on the ameliorative effect of crocin against lipopolysaccharide‑induced hippocampal toxicity in male albino rats [0.03%]
番红花黄素通过生化、组织病理学和免疫组化技术改善脂多糖诱导的雄性Sprague-Dawley大鼠海马毒性的作用机制研究
Eatemad A Awadalla,Ola Mohamed,Ahmed Abdelsadik et al.
Eatemad A Awadalla et al.
Background: Lipopolysaccharide (LPS)-induced neuroinflammation is widely used as an animal model for studying the mechanisms of neuroinflammation. Crocin, an active component of saffron (Crocus sativus L), possesses sever...