TELO2 mediates parabens-induced breast carcinogenesis: a comprehensive network analysis [0.03%]
对羟基苯甲酸酯诱导乳腺癌发生的机制研究：全面网络分析
Jing Ren,Xiaofen Li,Bin Dong et al.
Jing Ren et al.
Background: Parabens (PBs) are associated with an increased risk of breast cancer, yet their underlying molecular mechanisms remain poorly understood. This study aimed to comprehensively elucidate the targets and mechanis...
Mitigating nickel-induced toxicity: the protective role of native probiotic strains on oxidative stress and inflammatory pathways in mice lung tissues [0.03%]
镍毒性缓解：体内固有益生菌株对小鼠肺组织氧化应激和炎症途径的保护作用
Fatemeh Haririzadeh Jouriani,Elham Haj Agha Gholizadeh Khiavi,Niloofar Rezaie et al.
Fatemeh Haririzadeh Jouriani et al.
Background: Nickel exposure is a recognized environmental and occupational hazard that contributes to pulmonary oxidative stress and inflammation, potentially leading to chronic respiratory conditions. Probiotics, known f...
Exploring the toxic mechanism of excessive intake of naringin on drug-induced liver injury using network toxicology and experiment validation strategy [0.03%]
网络毒理学和实验验证策略探索柚皮素致药物性肝损伤的毒性机制
Yu Ding,Tong Yu,Jinrong He et al.
Yu Ding et al.
Multi-target antidiabetic therapy with voglibose, ubiquinone, and tempol: synergistic effects on liver and skeletal muscle in experimental type 2 diabetes [0.03%]
用于多靶点抗糖尿病疗法的伏格列波糖、辅酶Q和 TEMPOL：对实验型2糖尿病肝及骨骼肌的协同作用
Öznur Tufan Akarslan,Dudu Erkoç Kaya,Muhammed Bahaeddin Dörtbudak et al.
Öznur Tufan Akarslan et al.
Deciphering bisphenol A (BPA)-elicited osteoarthritis mechanisms through network toxicology and molecular docking, then de novo generation of novel therapeutic candidates [0.03%]
通过网络毒理学和分子对接破解双酚A诱导骨关节炎机制并从头生成新的治疗候选药物
Sumei Xu,Liping Jiang,Zhuo Zhang et al.
Sumei Xu et al.
Objective: Bisphenol A (BPA), a pervasive environmental pollutant, is increasingly associated with osteoarthritis (OA) development, yet its molecular mechanisms remain unknown. Currently, there is no definitive cure for O...
Mechanistic exploration of bisphenol A in primary Sjögren's syndrome using network toxicology, molecular docking, molecular dynamics simulations and experimental validation [0.03%]
运用网络毒理学、分子对接、分子动力学模拟和实验验证探讨双酚A在原发性舍格伦综合征中的作用机制
Zelin Wang,Jinle Zhang,Jingqi Dong et al.
Zelin Wang et al.
Primary Sjögren's syndrome (pSS) is a chronic autoimmune disorder marked by exocrine gland impairment and systemic manifestations. Environmental endocrine disruptors, including bisphenol A (BPA), have been associated with immunological dys...
A tissue-penetrably engineered deoxyribonuclease 1 to prevent nasal polyp formation in chronic rhinosinusitis [0.03%]
一种可穿透组织的工程脱氧核糖核酸酶1，可预防慢性鼻窦炎鼻息肉的形成
Su-Bin Kwak,Roza Khalmuratova,Sang-Jin Kim et al.
Su-Bin Kwak et al.
Background: Neutrophilic chronic rhinosinusitis (CRS) is characterized by persistent inflammation and often responds poorly to corticosteroid therapy. In this disease, neutrophil extracellular traps (NETs) are increasingl...
Exploring the mechanisms of Benzo[a]pyrene-induced lung adenocarcinoma based on network toxicology and machine learning [0.03%]
基于网络毒理学和机器学习的苯并[a]芘致肺腺癌机制探讨
Zhichao Wang,Chenghao Wang,Chenlu Wan et al.
Zhichao Wang et al.
Metallic nanoparticles in the treatment of staphylococcus infections: a scoping review [0.03%]
用于治疗金黄色葡萄球菌感染的金属纳米颗粒的研究回顾
Christian Kelechi Ezeh,Stephen Chijioke Emencheta,Kingsley Chisom Ugwuanyi
Christian Kelechi Ezeh
Human in vitro neuromuscular junction model to functionally dissect the pathogenic mechanism of anti-AChR autoantibody-positive myasthenia gravis [0.03%]
抗AChR自身抗体阳性重症肌无力体外神经肌肉接头功能模型的病理机制研究
Baehyun Shin,Monica Wang,John Yim et al.
Baehyun Shin et al.
Background: Myasthenia gravis is a rare autoimmune disease mediated by autoantibodies directed against acetylcholine receptors (AChRs) at the neuromuscular junction. These autoantibodies cause dysfunction through AChR blo...