Zinc as an adjunct treatment for reducing case fatality due to clinical severe infection in young infants: study protocol for a randomized controlled trial [0.03%]
一项关于锌联合治疗降低重度感染婴幼儿病死率有效性的随机对照试验的方案研究：临床试验注册号
Nitya Wadhwa,Sudha Basnet,Uma Chandra Mouli Natchu et al.
Nitya Wadhwa et al.
Background: An estimated 2.7 of the 5.9 million deaths in children under 5 years of age occur in the neonatal period. Severe infections contribute to almost a quarter of these deaths. Mortality due to severe infections in...
Randomized Controlled Trial
BMC pharmacology & toxicology. 2017 Jul 10;18(1):56. DOI:10.1186/s40360-017-0162-5 2017
Sema3A drastically suppresses tumor growth in oral cancer Xenograft model of mice [0.03%]
Sema3A在口腔癌小鼠异种移植模型中可显著抑制肿瘤生长
Chao Huang,Yi Wang,Jian-Hua Huang et al.
Chao Huang et al.
Background: Multiple studies suggest anti-angiogenesis to be a promising and rational option in cancer treatment. Interestingly, the axonal sprouting inhibitor semaphorin 3A (Sema3A), a potent suppressor of tumor angiogen...
Pharmacokinetic and pharmacodynamic modeling of oral mitiglinide on glucose lowering in healthy Chinese volunteers [0.03%]
米格列奈口服降糖的药动学和药效学模型研究在中国健康志愿者中的研究
Shijia Liu,Peidong Chen,Yang Zhao et al.
Shijia Liu et al.
Background: Mitiglinide is a widely used agent for diabetic treatment. We established a pharmacokinetic-pharmacodynamic (PK-PD) model to illustrate the relationship between mitiglinide plasma concentration and its glucose...
Actions of sesquiterpene lactones isolated from Moquiniastrum polymorphum subsp. floccosum in MCF7 cell line and their potentiating action on doxorubicin [0.03%]
莫喹亚斯特伦多聚物次种絮状物中的倍半萜内酯单体对MCF7细胞系的作用及其增敏阿霉素作用
Mariana de Oliveira Mauro,Renata Matuo,Natan de David et al.
Mariana de Oliveira Mauro et al.
Background: In order to obtain better clinical results in anticancer therapies, polychemotherapy or combination therapies are used. For this, the combinations are required to increase the efficacy and reduce the adverse r...
Drug-related problems and medication reviews among old people with dementia [0.03%]
痴呆老人的药物相关问题及用药评价
Bettina Pfister,Jeanette Jonsson,Maria Gustafsson
Bettina Pfister
Background: Drug-related problems, including medication errors and adverse drug events, are common among old people. Due to, for example, greater susceptibility to side effects, people with dementia are even more at risk ...
Randomized Controlled Trial
BMC pharmacology & toxicology. 2017 Jun 27;18(1):52. DOI:10.1186/s40360-017-0157-2 2017
Erratum to: Analgesic use in a Norwegian general population: change over time and high-risk use - The Tromsø Study [0.03%]
痛觉使用在挪威普通人群中的变化及高风险使用情况的更正—— Tromsø 研究的一部分
Per-Jostein Samuelsen,Lars Slørdal,Ulla Dorte Mathisen et al.
Per-Jostein Samuelsen et al.
Published Erratum
BMC pharmacology & toxicology. 2017 Jun 27;18(1):51. DOI:10.1186/s40360-017-0158-1 2017
Multifaceted interventions for improving spontaneous reporting of adverse drug reactions in a general hospital in China [0.03%]
在中国一家综合医院中改善自愿报告药品不良反应的多种干预措施
Huan Fang,Xiaowen Lin,Jun Zhang et al.
Huan Fang et al.
Background: The present study investigates changes in spontaneous reporting (SR) compliance and ADR patterns following adoption of a new hospital SR system, and multiple interventions designed for its improvement use unde...
Modulation of hepatic perfusion did not improve recovery from hepatic outflow obstruction [0.03%]
肝灌注调节不能改善肝流出道梗阻的恢复
J Arlt,W Wei,C Xie et al.
J Arlt et al.
Background: Focal hepatic venous outflow obstruction frequently occurs after extended liver resection and leads to a portal hypertension, arterial hypoperfusion and parenchymal necrosis. In this study, we investigated the...
The albumin-exendin-4 recombinant protein E2HSA improves glycemic control and β-cell function in spontaneous diabetic KKAy mice [0.03%]
基于人血清白蛋白的重组蛋白质E2HSA改善糖尿病自发型KKAy小鼠的血糖及胰岛素分泌功能
Caina Li,Shaocong Hou,Shuainan Liu et al.
Caina Li et al.
Background: E2HSA is a genetic fusion protein that consists of two tandem exendin-4 molecules that are covalently bonded to recombinant human serum albumin via a peptide linker. Previous studies have demonstrated that E2H...
Knockdown of subunit 3 of the COP9 signalosome inhibits C2C12 myoblast differentiation via NF-KappaB signaling pathway [0.03%]
敲除COP9信号传导体亚基3抑制NF-κB信号转导途径并促进C2C12肌母细胞分化
Mariam A Ba,Jeffrey Surina,Cherie A Singer et al.
Mariam A Ba et al.
Background: The COP9 signalosome (CSN) is a conserved protein complex composed of 8 subunits designated CSN1-CSN8. CSN3 represents the third subunit of the CSN and maintains the integrity of the complex. CSN3 binds to the...