Subchronic exposure to tri-ortho-cresyl phosphate induces nephrotoxicity through induction of oxidative stress with neuropathy target esterase inhibition [0.03%]
邻苯二甲酸三正丁酯亚慢性暴露通过抑制神经毒靶酯酶诱导氧化应激导致肾毒性
Jiaqi Wang,Rui Wang,Ningzhe Wu et al.
Jiaqi Wang et al.
Novel mechanisms of atrazine endocrine disruption: an integrated approach reveals progesterone and glucocorticoid receptor targeting [0.03%]
阿特拉津干扰内分泌的新机制——整合方法揭示了孕激素和糖皮质激素受体靶向作用
Chaoyuan Jin,Ruijinlin Hao,Xingxing Ren et al.
Chaoyuan Jin et al.
Decrypting potential mechanisms linking ochratoxin A to hepatocellular carcinoma: an integrated approach combining toxicology, machine learning, molecular docking, and molecular dynamics simulation [0.03%]
基于毒理学、机器学习、分子对接和分子动力学模拟的整合方法解析黄曲霉毒素A与肝细胞癌潜在机制之间的联系
Junyi Zhuo,Hua Wu,Xiaoling Zhou et al.
Junyi Zhuo et al.
Background: Ochratoxin A (OTA), a common food-borne mycotoxin, is a potential human carcinogen, yet the specific molecular mechanisms linking it to hepatocellular carcinoma (HCC) remain unclear. ...
Drug re-purposing to improve outcomes in the management of prostate cancer - aims, outcome measures and design of current phase III trials [0.03%]
药物再定位以改善前列腺癌治疗效果的现状、结果评估及当前III期临床试验的设计方向
Duncan C Gilbert,Ruth E Langley,Dami Ayadi et al.
Duncan C Gilbert et al.
Preservative-free latanoprost induces meibomian gland dysfunction through inflammatory and oxidative stress pathways [0.03%]
无防腐剂拉坦前列腺素通过炎症和氧化应激途径诱导睑板腺功能障碍
Caihong Huang,Yiran Yang,Shinan Wu et al.
Caihong Huang et al.
Canadine protects against doxorubicin-induced cardiac and brain injury by inhibiting Oxidative stress [0.03%]
加拿大宁通过抑制氧化应激保护多柔比星致心脏和大脑损伤
Xianghui Zeng,Qingfeng Zeng,Qi Luo et al.
Xianghui Zeng et al.
Compound 7 h exerts its anti-oncogenic effects on colorectal cancer cells by inducing death-receptor-mediated apoptosis, promoting DNA damage, and obstructing autophagic flux [0.03%]
化合物7 h通过诱导死亡受体介导的细胞凋亡、促进DNA损伤和阻碍自噬流量来对结直肠癌细胞产生抗致癌作用
Donglin Yang,Yanlai Fu,Jiuhong Huang et al.
Donglin Yang et al.
Mechanistic study of deoxycholic acid in colorectal cancer based on network toxicology and machine learning approaches [0.03%]
基于网络毒理学和机器学习的脱氧胆酸在结直肠癌中作用机制研究
Yulai Yin,Xueqing Li,Yixuan Xie et al.
Yulai Yin et al.
Integrated network toxicology, molecular docking, and molecular dynamics simulation reveals mechanisms of benzo[a]pyrene-induced pan-cancer [0.03%]
整合网络毒理学、分子对接和分子动力学模拟揭示苯并[a]芘致泛癌的机制
Yuxin Pan,Shuqi Qin,Cheng Chen et al.
Yuxin Pan et al.
Myricetin protects against doxorubicin-induced liver damage by modulating oxidative and inflammatory pathways [0.03%]
芦丁通过调节氧化和炎症途径保护吉西他滨引起的肝损伤
Lava Mohammed Sabir,Hiewa Othman Dyary
Lava Mohammed Sabir
Background: Doxorubicin (Dox) is a highly effective chemotherapy drug used to treat various cancers. However, its clinical application is limited by liver toxicity, which is mainly caused by oxidative stress, inflammation...